Multiple Andreev reflections and enhanced shot noise in diffusive SNS junctions

We study the dc conductance and current fluctuations in diffusive voltage biased SNS junctions with a tunnel barrier inside the mesoscopic normal region. We find that at subgap voltages, eV<2Delta/n, the current associated with the chain of n Andreev reflections is mapped onto the quasiparticle flow through a structure of n+1 voltage biased barriers connected by diffusive conductors. As a result, the current-voltage characteristic of a long SNINS structure obeys Ohm's law, in spite of the complex multiparticle transport process. At the same time, nonequilibrium heating of subgap electrons produces giant shot noise with pronounced subharmonic gap structure which corresponds to stepwise growth of the effective transferred charge. At eV\to 0, the shot noise approaches the magnitude of the Johnson-Nyquist noise with the effective temperature T^*=Delta/3, and the effective charge increases as (e/3)(1 + 2Delta/eV), with the universal ``one third suppression'' factor. We analyse the role of inelastic scattering and present a criterion of strong nonequilibrium.Comment: 4 pages, 2 figure

Superconducting d-wave junctions: The disappearance of the odd ac components

We study voltage-biased superconducting planar d-wave junctions for arbitrary transmission and arbitrary orientation of the order parameters of the superconductors. For a certain orientation of the superconductors the odd ac components disappear, resulting in a doubling of the Josephson frequency. We study the sensitivity of this disappearance to orientation and compare with experiments on grain boundary junctions. We also discuss the possibility of a current flow parallel to the junction.Comment: 5 pages, 3 figure

Resonant multiple Andreev reflections in mesoscopic superconducting junctions

We investigate the properties of subharmonic gap structure (SGS) in superconducting quantum contacts with normal-electron resonances. We find two distinct new features of the SGS in resonant junctions which distinguish them from non-resonant point contacts: (i) The odd-order structures on the current-voltage characteristics of resonant junctions are strongly enhanced and have pronounced peaks, while the even-order structures are suppressed, in the case of a normal electron resonance being close to the Fermi level. (ii) Tremendous current peaks develop at $eV=\pm 2E_0$ where $E_0$ indicates a distance of the resonance to the Fermi level. These properties are determined by the effect of narrowing of the resonance during multiple Andreev reflections and by overlap of electron and hole resonances.Comment: 13 pages, 10 figure

Results from the Survey of Antibiotic Resistance (SOAR) 2011–13 in Ukraine

Objectives: To determine the antibiotic susceptibility of respiratory isolates of Streptococcus pneumoniae and Haemophilus influenzae collected in 2011–13 from Ukraine. Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: A total of 134 isolates of S. pneumoniae and 67 of H. influenzae were collected from eight sites in Ukraine. Overall, 87.3% of S. pneumoniae were penicillin susceptible by CLSI oral breakpoints and 99.3% by CLSI iv breakpoints. Susceptibility to amoxicillin/clavulanic acid (amoxicillin), ceftriaxone and levofloxacin was 100% by CLSI and PK/PD breakpoints. Cephalosporin and macrolide susceptibility was ≥95.5% and 88.1%, respectively using CLSI breakpoints. Trimethoprim/sulfamethoxazole was essentially inactive against pneumococci. Of the 67 H. influenzae tested, 4.5% were b-lactamase positive and all H. influenzae were fully susceptible to amoxicillin/ clavulanic acid, ceftriaxone, ciprofloxacin, cefixime and levofloxacin (all breakpoints). Cefuroxime susceptibility was 100% by CLSI but 73.1% by EUCAST and PK/PD breakpoints. A discrepancy was found in macrolide susceptibility between CLSI (100% susceptible), EUCAST (22%–43% susceptible) and PK/PD (0%–22% susceptible) breakpoints. Trimethoprim/sulfamethoxazole was poorly active (59.7% susceptible). Conclusions: Generally, antibiotic resistance was low in respiratory pathogens from Ukraine. However, only amoxicillin/clavulanic acid (amoxicillin), ceftriaxone and levofloxacin were fully active against both species. Trimethoprim/sulfamethoxazole was the least active, particularly against S. pneumoniae. Some susceptibility differences were apparent between CLSI, EUCAST and PK/PD breakpoints, especially with macrolides against H. influenzae. These data suggest that further efforts are required to harmonize these international breakpoints. Future studies are warranted to monitor continued low resistance levels in Ukraine compared with other parts of Eastern Europe

Adiabatic Dynamics of Superconducting Quantum Point Contacts

Starting from the quasiclassical equations for non-equilibrium Green's functions we derive a simple kinetic equation that governs ac Josephson effect in a superconducting quantum point contact at small bias voltages. In contrast to existing approaches the kinetic equation is valid for voltages with arbitrary time dependence. We use this equation to calculate frequency-dependent linear conductance, and dc $I\!-\!V$ characteristics with and without microwave radiation for resistively shunted quantum point contacts. A novel feature of the $I\!-\!V$ characteristics is the excess current $2I_c/\pi$ appearing at small voltages. An important by-product of our derivation is the analytical proof that the microscopic expression for the current coincides at arbitrary voltages with the expression that follows from the Bogolyubov-de Gennes equations, if one uses appropriate amplitudes of Andreev reflection which contain information about microscopic structure of the superconductors.Comment: 12 Pages, REVTEX 3.0, 3 figures available upon reques

Results from the Survey of Antibiotic Resistance (SOAR) 2016–17 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints

Objectives: To determine antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolates from community-acquired respiratory tract infections (CA-RTIs) collected in 2016–17 from Ukraine. Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: A total of 177 viable clinical isolates, including 78 S. pneumoniae and 99 H. influenzae, were collected. Overall, 98% of S. pneumoniae isolates were susceptible to penicillin by CLSI IV or EUCAST high-dose breakpoints and 73.1% were susceptible by CLSI oral or EUCAST low-dose IV breakpoints. Susceptibility rates of 76.9%–100% were observed for most antibiotics by all breakpoints except trimethoprim/sulfamethoxazole (41%–69.2%) and cefaclor, which showed the greatest difference between breakpoints: 0% by EUCAST, 28.2% by PK/PD and 73.1% by CLSI. All S. pneumoniae isolates were susceptible to amoxicillin/clavulanic acid by CLSI and PK/PD breakpoints. H. influenzae isolates were almost all b-lactamase negative (90.9%). One isolate was blactamase negative and ampicillin resistant (BLNAR) by CLSI and four isolates were BLNAR by EUCAST criteria. Susceptibility of isolates was high (90.9%) by CLSI breakpoints for all antibiotics tested except trimethoprim/ sulfamethoxazole (61.6%). Susceptibility using EUCAST breakpoints was similar for ampicillin (90.9%) and amoxicillin/clavulanic acid (95%) but was low for cefuroxime (oral), where only 10.1% of isolates were susceptible. All S. pneumoniae and H. influenzae isolates were susceptible to the fluoroquinolones by all breakpoints. Susceptibility to ceftriaxone was also 100% for H. influenzae and 91% for S. pneumoniae isolates by all breakpoints. The application of different EUCAST breakpoints for low and higher doses for some of the antibiotics (amoxicillin, amoxicillin/clavulanic acid, ampicillin, penicillin, ceftriaxone, clarithromycin, erythromycin, levofloxacin and trimethoprim/sulfamethoxazole) allowed, for the first time in a SOAR study, the effect of raising the dosage on susceptibility to be quantified. Conclusions: Antibiotic susceptibility in these respiratory tract pathogens was generally high in Ukraine. These data are important for empirical therapy choices in the treatment of CA-RTIs

Current noise in long diffusive SNS junctions in the incoherent MAR regime

Spectral density of current fluctuations at zero frequency is calculated for a long diffusive SNS junction with low-resistive interfaces. At low temperature, T << Delta, the subgap shot noise approaches linear voltage dependence, S=(2/ 3R)(eV + 2Delta), which is the sum of the shot noise of the normal conductor and voltage independent excess noise. This result can also be interpreted as the 1/3-suppressed Poisson noise for the effective charge q = e(1+2Delta/eV) transferred by incoherent multiple Andreev reflections (MAR). At higher temperatures, anomalies of the current noise develop at the gap subharmonics, eV = 2Delta/n. The crossover to the hot electron regime from the MAR regime is analyzed in the limit of small applied voltages.Comment: improved version, to be published in Phys. Rev.

DC current through a superconducting two-barrier system

We analyze the influence of the structure within a SNS junction on the multiple Andreev resonances in the subgap I-V characteristics. Coherent interference processes and incoherent propagation in the normal region are considered. The detailed geometry of the normal region where the voltage drops in superconducting contacts can lead to observable effects in the conductance at low voltages.Comment: 11 pages, including 7 postscript file

Hamiltonian approach to the ac Josephson effect in superconducting-normal hybrid systems

The ac Josephson effect in hybrid systems of a normal mesoscopic conductor coupled to two superconducting (S) leads is investigated theoretically. A general formula of the ac components of time-dependent current is derived which is valid for arbitrary interactions in the normal region. We apply this formula to analyze a S-normal-S system where the normal region is a noninteracting single level quantum dot. We report the physical behavior of time-averaged nonequilibrium distribution of electrons in the quantum dot, the formation of Andreev bound states, and ac components of the time-dependent current. The distribution is found to exhibit a population inversion; and all Andreev bound states between the superconducting gap $\Delta$ carry the same amount of current and in the same flow direction. The ac components of time-dependent current show strong oscillatory behavior in marked contrast to the subharmonic gap structure of the average current.Comment: 23 pages, 10 figures, LaTe

Superconducting single-mode contact as a microwave-activated quantum interferometer

The dynamics of a superconducting quantum point contact biased at subgap voltages is shown to be strongly affected by a microwave electromagnetic field. Interference among a sequence of temporally localized, microwave-induced Landau-Zener transitions between current carrying Andreev levels results in energy absorption and in an increase of the subgap current by several orders of magnitude. The contact is an interferometer in the sense that the current is an oscillatory function of the inverse bias voltage. Possible applications to Andreev-level spectroscopy and microwave detection are discussed