Dynamics of the in-run in ski jumping: a simulation study

Utilisation d'un modèle de simulation à 4 segments, intégrant les forces aérodynamiques et de friction de la neige pour étudier la dynamique du skieur sur la piste d'élan depuis un départ statique

Critical Boundary Conditions for the Effective String

Gauge systems in the confining phase induce constraints at the boundaries of the effective string, which rule out the ordinary bosonic string even with short distance modifications. Allowing topological excitations, corresponding to winding around the colour flux tube, produces at the quantum level a universal free fermion string with a boundary phase nu=1/4. This coincides with a model proposed some time ago in order to fit Monte Carlo data of 3D and 4D Lattice gauge systems better. A universal value of the thickness of the colour flux tube is predicted.Comment: 9 pages + 1 figur

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination

The "canonical" proteasomal degradation signal is a substrate-anchored polyubiquitin chain. However, a handful of proteins were shown to be targeted following monoubiquitination. In this study, we established-in both human and yeast cells-a systematic approach for the identification of monoubiquitination-dependent proteasomal substrates. The cellular wild-type polymerizable ubiquitin was replaced with ubiquitin that cannot form chains. Using proteomic analysis, we screened for substrates that are nevertheless degraded under these conditions compared with those that are stabilized, and therefore require polyubiquitination for their degradation. For randomly sampled representative substrates, we confirmed that their cellular stability is in agreement with our screening prediction. Importantly, the two groups display unique features: monoubiquitinated substrates are smaller than the polyubiquitinated ones, are enriched in specific pathways, and, in humans, are structurally less disordered. We suggest that monoubiquitination-dependent degradation is more widespread than assumed previously, and plays key roles in various cellular processes

‘Maintaining balance and harmony’: Javanese perceptions of health and cardiovascular disease

Community intervention programmes to reduce cardiovascular disease (CVD) risk factors within urban communities in developing countries are rare. One possible explanation is the difficulty of designing an intervention that corresponds to the local context and culture

The parent?infant dyad and the construction of the subjective self

Developmental psychology and psychopathology has in the past been more concerned with the quality of self-representation than with the development of the subjective agency which underpins our experience of feeling, thought and action, a key function of mentalisation. This review begins by contrasting a Cartesian view of pre-wired introspective subjectivity with a constructionist model based on the assumption of an innate contingency detector which orients the infant towards aspects of the social world that react congruently and in a specifically cued informative manner that expresses and facilitates the assimilation of cultural knowledge. Research on the neural mechanisms associated with mentalisation and social influences on its development are reviewed. It is suggested that the infant focuses on the attachment figure as a source of reliable information about the world. The construction of the sense of a subjective self is then an aspect of acquiring knowledge about the world through the caregiver's pedagogical communicative displays which in this context focuses on the child's thoughts and feelings. We argue that a number of possible mechanisms, including complementary activation of attachment and mentalisation, the disruptive effect of maltreatment on parent-child communication, the biobehavioural overlap of cues for learning and cues for attachment, may have a role in ensuring that the quality of relationship with the caregiver influences the development of the child's experience of thoughts and feelings

Dynamics of Two Higgs Doublet CP Violation and Baryogenesis at the Electroweak Phase Transition

We quantitatively study the charge transport mechanism of electroweak baryogenesis in a realistic two-Higgs-doublet model, comparing the contributions from quarks and leptons reflecting from electroweak domain walls, and comparing the exact profile of the CP-violating phase with a commonly used ansatz. We note that the phenomenon of spontaneous CP violation at high temperature can occur in this model, even when there is no CP violation at zero temperature. We include all known effects which are likely to influence the baryon production rate, including strong sphalerons, the nontrivial dispersion relations of the quasiparticles in the plasma, and Debye screening of gauged charges. We confirm the claim of Joyce, Prokopec and Turok that the reflection of tau leptons from the wall gives the dominant effect. We conclude that this mechanism is marginally strong enough to produce the observed baryon asymmetry of the universe.Comment: 49 pp. latex, 6 figures; section on diffusion expanded and corrected, published versio