On univalent polynomials and related classes of functions

Imperial Users onl

Control of Transcriptional Elongation by RNA Polymerase II: A Retrospective

The origins of our current understanding of control of transcription elongation lie in pioneering experiments that mapped RNA polymerase II on viral and cellular genes. These studies first uncovered the surprising excess of polymerase molecules that we now know to be situated at the at the 5′ ends of most genes in multicellular organisms. The pileup of pol II near transcription start sites reflects a ubiquitous bottle-neck that limits elongation right at the start of the transcription elongation. Subsequent seminal work identified conserved protein factors that positively and negatively control the flux of polymerase through this bottle-neck, and make a major contribution to control of gene expression

David Brannan reflects on the impact of CHDS theses by Candice Wright, Richard Fleece, David Heller, Gary Settle, Devon Bell, and Michelle Mallek

The article record may be found at https://www.hsaj.org/articles/17409Sponsored the U. S. Department of Homeland Security’s National Preparedness Directorate, FEMA, CHDS is part of the Naval Postgraduate School (NPS)

Funding and Other Resources for Beginning Researchers

Despite the fact that osteopathic research is essential for the continued advancement of our profession, such research is lacking. One barrier is the attainment of funding resources to launch and continue quality research studies. In the present article, the authors outline resources for the early stages of research and provide guidance for grant proposal preparation, if it is determined that external funding is needed. Free and low-cost resources for obtaining preliminary data and sources of external funds are described. An overview of grant writing and information on where to obtain training is presented. Information on proposal writing basics, tips to increase the chances of success, the grant application process, and basic proposal and budget requirements is provided. Potential funding sources appropriate for beginning investigators are listed, as well. Suggestions are offered for revising and resubmitting unsuccessful proposals

David Brannan reviews Bruce Hoffman, Inside Terrorism (three editions, 1998, 2006, and 2017)

The article record may be found at https://www.hsaj.org/articles/21484Sponsored the U. S. Department of Homeland Security’s National Preparedness Directorate, FEMA, CHDS is part of the Naval Postgraduate School (NPS)

Opportunities to engage health system leaders in whole systems approaches to physical activity in England

Background: Physical activity plays an important role in maintaining good health and wellbeing, non-communicable disease prevention and can improve healthcare outcomes. Some progress is being made on incorporating physical activity into routine care, but less on engaging health system leaders in the ‘whole systems’ approaches which are increasingly recognised as important for addressing complex public health challenges such as physical inactivity. This commentary builds upon the findings of a recent study and aims to identify opportunities for engaging National Health Service (NHS) systems leaders in whole systems approaches to physical activity. Opportunities for action in England: Pockets of good practice exist from which lessons can be learned, but there are systemic issues that discourage and create barriers, and a need for meaningful engagement, leadership and action at national, regional and local levels. National and regional actors like Sport England, NHS England, health professional bodies, Active Partnerships, the Local Government Association and the Office for Health Improvement and Disparities can encourage and support government and the NHS to change policy drivers, culture and practices. Emerging opportunities include the 2021 White Paper Integration and Innovation, development of local integrated care systems, leadership from health charities and investment in non-clinical interventions (‘social prescribing’). At local level, public health and physical activity specialists and other organisations have a key role as champions and facilitators of local whole systems approaches and engagement of local NHS leaderships. Finally, although whole systems action is about collaborative leadership, individual champions of physical activity can make a difference in influencing NHS leaders at every level towards whole systems working