Piloted-simulation study of effects of vortex flaps on low-speed handling qualities of a Delta-wing airplane

A piloted-simulation study was conducted to investigate the effects of vortex flaps on low-speed handling qualities of a delta-wing airplane. The simulation math model was developed from wind tunnel tests of a 0.15 scale model of the F-106B airplane. Pilot evaluations were conducted using a six-degree-of-freedom motion base simulator. The results of the investigation showed that the reduced static longitudinal stability caused by the vortex flaps significantly degraded handling qualities in the approach-to-landing task. Acceptable handling qualities could be achieved by limiting the aft center-of-gravity location, consequently reducing the operational envelope of the airplane. Further improvement were possible by modifying the flight control force-feel system to reduce pitch-control sensitivity

Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.

A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults. The emergence of RNA sequencing (RNA-seq) provides an opportunity to obtain an unbiased, comprehensive, and quantitative view of gene expression differences in defined cell types from different age groups. An examination of ex vivo human monocyte responses to lipopolysaccharide stimulation or Listeria monocytogenes infection by RNA-seq revealed extensive similarities between neonates, young adults, and older adults, with an unexpectedly small number of genes exhibiting statistically significant age-dependent differences. By examining the differentially induced genes in the context of transcription factor binding motifs and RNA-seq data sets from mutant mouse strains, a previously described deficiency in interferon response factor-3 activity could be implicated in most of the differences between newborns and young adults. Contrary to these observations, older adults exhibited elevated expression of inflammatory genes at baseline, yet the responses following stimulation correlated more closely with those observed in younger adults. Notably, major differences in the expression of constitutively expressed genes were not observed, suggesting that the age-related differences are driven by environmental influences rather than cell-autonomous differences in monocyte development

Sequence Stratigraphy and Depositional Facies of Lower Ordovician Cyclic Carbonate Rocks, Southern Missouri, U.S.A.

Lower Ordovician cyclic carbonate strata of southern Missouri were deposited in a warm, shallow, epeiric sea on a fully aggraded carbonate platform. Sedimentological characteristics distinguish the Jefferson City and Cotter dolomites from the underlying Gasconade and Roubidoux formations. Mixed carbonate-siliciclastic sedimentation characterizes the Roubidoux Formation, with sandstones accounting for up to 60% of sedimentation. The Gasconade, Jefferson City, and Cotter dolomites exhibit an increased occurrence of chalcedonic chert nodules in very similar shape and texture to the gypsum and anhydrite nodules common on modern sabkha supratidal flats. Casts of halite and ghosts of gypsum laths also exist in the Jefferson City and Cotter strata but are rarely found in the underlying units. Facies analysis from drill cores and outcrop sections provides the basis for identifying two major meter-scale cycle types. Type I cycles consist of algal stromatolites, tidal-flat laminites (mechanical and algal), ooid grainstones, wavy peloidal wackestones, and quartz sandstones interpreted as peritidal facies. They are the dominant components of the Roubidoux Formation, Jefferson City Dolomite, and Cotter Dolomite. Type II cycles consist mostly of subtidal facies such as strongly burrowed mudstone, thrombolite boundstone, and stromatolites. Type I cycles are thinner and represent highstand systems tracts, whereas the thicker type II cycles represent transgressive systems tracts and are dominant in the Gasconade Dolomite. The cycle stacking patterns, facies changes, and the intrabasinal correlatability of Fischer plots made from the widely spaced sections argue for a eustatic control on sea-level fluctuation on the platform. Interbasinal correlation with other North American basins is possible using biostratigraphic information and comparison of Fischer plots. Five Missouri sequences correlate with those described for other regions. The continent-wide uniformity in cycle stacking patterns indicates a primarily eustatic control on Lower Ordovician meter-scale cycle development. Regional tectonic and autocyclic controls probably account for general differences in sedimentation pattern among the correlated basins

Piloted simulation study of an ILS approach of a twin-pusher business/commuter turboprop aircraft configuration

A six-degree-of-freedom nonlinear simulation of a twin-pusher, turboprop business/commuter aircraft configuration representative of the Cessna ATPTB (Advanced turboprop test bed) was developed for use in piloted studies with the Langley General Aviation Simulator. The math models developed are provided, simulation predictions are compared with with Cessna flight-test data for validation purposes, and results of a handling quality study during simulated ILS (instrument landing system) approaches and missed approaches are presented. Simulated flight trajectories, task performance measures, and pilot evaluations are presented for the ILS approach and missed-approach tasks conducted with the vehicle in the presence of moderate turbulence, varying horizontal winds and engine-out conditions. Six test subjects consisting of two research pilots, a Cessna test pilot, and three general aviation pilots participated in the study. This effort was undertaken in cooperation with the Cessna Aircraft Company

Free-flight investigation of forebody blowing for stability and control

A free-flight wind-tunnel investigation was conducted on a generic fighter model with forebody pneumatic vortex control for high angle-of-attack directional control. This is believed to be the first flight demonstration of a forebody blowing concept integrated into a closed-loop flight control system for stability augmentation and control. The investigation showed that the static wind tunnel estimates of the yaw control available generally agreed with flight results. The control scheme for the blowing nozzles consisted of an on/off control with a deadband. Controlled flight was obtained for the model using forebody blowing for directional control to beyond 45 deg. angle of attack

Ares-I-X Stability and Control Flight Test: Analysis and Plans

The flight test of the Ares I-X vehicle provides a unique opportunity to reduce risk of the design of the Ares I vehicle and test out design, math modeling, and analysis methods. One of the key features of the Ares I design is the significant static aerodynamic instability coupled with the relatively flexible vehicle - potentially resulting in a challenging controls problem to provide adequate flight path performance while also providing adequate structural mode damping and preventing adverse control coupling to the flexible structural modes. Another challenge is to obtain enough data from the single flight to be able to conduct analysis showing the effectiveness of the controls solutions and have data to inform design decisions for Ares I. This paper will outline the modeling approaches and control system design to conduct this flight test, and also the system identification techniques developed to extract key information such as control system performance (gain/phase margins, for example), structural dynamics responses, and aerodynamic model estimations

NASA's Learn-to-Fly Project Overview

Learn-to-Fly (L2F) is an advanced technology development effort aimed at assessing the feasibility of real-time, self-learning flight vehicles. Specifically, research has been conducted on merging real-time aerodynamic modeling, learning adaptive control, and other disciplines with the goal of using this learn to fly methodology to replace the current iterative vehicle development paradigm, substantially reducing the typical ground and flight testing requirements for air vehicle design. Recent activities included an aggressive flight test program with unique fully autonomous fight test vehicles to rapidly advance L2F technology. This paper presents an overview of the project and key components

Calibration and Flight Results for the Ares I-X 5-Hole Probe

Flight and calibration results are presented for the Ares I-X 5-hole probe. The probe is calibrated by using a combination of wind tunnel, CFD, and other numerical modeling techniques. This is then applied to the probe flight data and comparisons are made between the vanes and 5-hole probe. Using this and other data it is shown the probe was corrupted by water rendering that measurement unreliable

Efficient Testing Combining Design of Experiment and Learn-to-Fly Strategies

Rapid modeling and efficient testing methods are important in a number of aerospace applications. In this study efficient testing strategies were evaluated in a wind tunnel test environment and combined to suggest a promising approach for both ground-based and flight-based experiments. Benefits of using Design of Experiment techniques, well established in scientific, military, and manufacturing applications are evaluated in combination with newly developing methods for global nonlinear modeling. The nonlinear modeling methods, referred to as Learn-to-Fly methods, utilize fuzzy logic and multivariate orthogonal function techniques that have been successfully demonstrated in flight test. The blended approach presented has a focus on experiment design and identifies a sequential testing process with clearly defined completion metrics that produce increased testing efficiency

Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury.

Background:Recent studies have demonstrated the vital influence of commensal microbial communities on human health. The central role of the gut in the response to injury is well described; however, no prior studies have used culture-independent profiling techniques to characterize the gut microbiome after severe trauma. We hypothesized that in critically injured patients, the gut microbiome would undergo significant compositional changes in the first 72 hours after injury. Methods:Trauma stool samples were prospectively collected via digital rectal examination at the time of presentation (0 hour). Patients admitted to the intensive care unit (n=12) had additional stool samples collected at 24 hours and/or 72 hours. Uninjured patients served as controls (n=10). DNA was extracted from stool samples and 16S rRNA-targeted PCR amplification was performed; amplicons were sequenced and binned into operational taxonomic units (OTUs; 97% sequence similarity). Diversity was analyzed using principle coordinates analyses, and negative binomial regression was used to determine significantly enriched OTUs. Results:Critically injured patients had a median Injury Severity Score of 27 and suffered polytrauma. At baseline (0 hour), there were no detectable differences in gut microbial community diversity between injured and uninjured patients. Injured patients developed changes in gut microbiome composition within 72 hours, characterized by significant alterations in phylogenetic composition and taxon relative abundance. Members of the bacterial orders Bacteroidales, Fusobacteriales and Verrucomicrobiales were depleted during 72 hours, whereas Clostridiales and Enterococcus members enriched significantly. Discussion:In this initial study of the gut microbiome after trauma, we demonstrate that significant changes in phylogenetic composition and relative abundance occur in the first 72 hours after injury. This rapid change in intestinal microbiota represents a critical phenomenon that may influence outcomes after severe trauma. A better understanding of the nature of these postinjury changes may lead to the ability to intervene in otherwise pathological clinical trajectories. Level of evidence:III. Study type:Prognostic/epidemiological