8,854 research outputs found
Parametric test of a zirconium (4) oxide-polyacrylic acid dual layer hyperfiltration membrane with spacecraft washwater
Performance data consisting of solute rejections and product flux were measured, as dependent on the operation parameters. These parameters and ranges were pressure (500,000 n/m2 to 700,000 n/m2), temperature (74 C to 95 C), velocity (1.6 M/sec to 10 M/sec), and concentration (up to 14x). Tests were carried out on analog washwater. Data presented include rejections of organic materials, ammonia, urea, and an assortment of ions. The membrane used was deposited in situ on a porcelain ceramic substrate
Discovery of an M9.5 Candidate Brown Dwarf in the TW Hydrae Association - DENIS J124514.1-442907
We report the discovery of a fifth candidate substellar system in the ~5-10
Myr TW Hydrae Association - DENIS J124514.1-442907. This object has a NIR
spectrum remarkably similar to that of 2MASS J1139511-315921, a known TW Hydrae
brown dwarf, with low surface gravity features such as a triangular-shaped
H-band, deep H2O absorption, weak alkali lines, and weak hydride bands. We find
an optical spectral type of M9.5 and estimate a mass of <24 M_Jup, assuming an
age of ~5-10 Myr. While the measured proper motion for DENIS J124514.1-442907
is inconclusive as a test for membership, its position in the sky is coincident
with the TW Hydrae Association. A more accurate proper motion measurement,
higher resolution spectroscopy for radial velocity, and a parallax measurement
are needed to derive the true space motion and to confirm its membership.Comment: 8 pages - emulateapj style, 2 figures, 3 tables. Accepted to ApJL.
Fixed typos, added reference, added footnot
Quantified Uncertainty in Thermodynamic Modeling for Materials Design
Phase fractions, compositions and energies of the stable phases as a function
of macroscopic composition, temperature, and pressure (X-T-P) are the principle
correlations needed for the design of new materials and improvement of existing
materials. They are the outcomes of thermodynamic modeling based on the
CALculation of PHAse Diagrams (CALPHAD) approach. The accuracy of CALPHAD
predictions vary widely in X-T-P space due to experimental error, model
inadequacy and unequal data coverage. In response, researchers have developed
frameworks to quantify the uncertainty of thermodynamic property model
parameters and propagate it to phase diagram predictions. In previous studies,
uncertainty was represented as intervals on phase boundaries (with respect to
composition) or invariant reactions (with respect to temperature) and was
unable to represent the uncertainty in eutectoid reactions or in the stability
of phase regions. In this work, we propose a suite of tools that leverages
samples from the multivariate model parameter distribution to represent
uncertainty in forms that surpass previous limitations and are well suited to
materials design. These representations include the distribution of phase
diagrams and their features, as well as the dependence of phase stability and
the distributions of phase fraction, composition activity and Gibbs energy on
X-T-P location - irrespective of the total number of components. Most
critically, the new methodology allows the material designer to interrogate a
certain composition and temperature domain and get in return the probability of
different phases to be stable, which can positively impact materials design
Aerothermodynamic Assessment of Corrugated Panel Thermal Protection Systems
The feasibility of using corrugated panels as a thermal protection system for an advanced space transportation vehicle was investigated. The study consisted of two major tasks: development of improved correlations for wind tunnel heat transfer and pressure data to yield design techniques, and application of the design techniques to determine if corrugated panels have application future aerospace vehicles. A single-stage-to-orbit vehicle was used to assess advantages and aerothermodynamic penalties associated with use of such panels. In the correlation task, experimental turbulent heat transfer and pressure data obtained on corrugation roughened surfaces during wind tunnel testing were analyzed and compared with flat plate data. The correlations and data comparisons included the effects of a large range of geometric, inviscid flow, internal boundary layer, and bulk boundary layer parameters in supersonic and hypersonic flow
Inside-out neuropharmacology of nicotinic drugs
Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of chronic exposure to nicotine; but it is one of several consequences of pharmacological chaperoning by nicotine and by some other nicotinic ligands, especially agonists. Nicotinic ligands permeate through cell membranes, bind to immature AChR oligomers, elicit incompletely understood conformational reorganizations, increase the interaction between adjacent AChR subunits, and enhance the maturation process toward stable AChR pentamers. These changes and stabilizations in turn lead to increases in both anterograde and retrograde traffic within the early secretory pathway. In addition to the eventual upregulation of AChRs at the plasma membrane, other effects of pharmacological chaperoning include modifications to endoplasmic reticulum stress and to the unfolded protein response. Because these processes depend on pharmacological chaperoning within intracellular organelles, we group them as “inside-out pharmacology”. This term contrasts with the better-known, acute, “outside-in” effects of activating and desensitizing plasma membrane AChRs. We review current knowledge concerning the mechanisms and consequences of inside-out pharmacology
Validation of preoperative variables and stratification of patients to help predict benefit of cytoreductive nephrectomy in the targeted therapy ERA
Discovery of the Interstellar Chiral Molecule Propylene Oxide (CHCHCHO)
Life on Earth relies on chiral molecules, that is, species not superimposable
on their mirror images. This manifests itself in the selection of a single
molecular handedness, or homochirality, across the biosphere. We present the
astronomical detection of a chiral molecule, propylene oxide (CHCHCHO),
in absorption toward the Galactic Center. Propylene oxide is detected in the
gas phase in a cold, extended molecular shell around the embedded, massive
protostellar clusters in the Sagittarius B2 star-forming region. This material
is representative of the earliest stage of solar system evolution in which a
chiral molecule has been found
Idiopathic Obturator Internus Strain in a Collegiate Tennis Player: A Case Report
Objective: Present a clinical case detailing the evaluation and treatment of an idiopathic obturator internus strain in a collegiate tennis player. Background: Isolated injury to the obturator internus muscle is uncommon. In cases that do present, patients often report often report a mechanism for injury involving falling or kicking. In previously reported cases, diagnosis is confirmed by magnetic resonance imaging. Treatment: Patient presented to the athletic training clinic complaining of left hip external rotator tightness and pain, and was unable to recall a mechanism of injury. Following the failure of conservative treatment, final diagnosis of a grade II obturator internus strain was made via magnetic resonance imaging. Using the confirmed diagnosis, the athletic training staff was able to progress strengthening and range of motion exercises until the patient returned to competition six weeks post injury. Conclusion: Obturator internus strains are possible causes of posterior hip pain and tightness. Currently, there are no reliable evaluation techniques for the obturator internus that do not involve diagnostic imaging. Further research needs to be conducted to determine if there are any signs and symptoms specific to obturator internus injuries
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