61 research outputs found
Facteurs predictifs dâatteinte ganglionnaire centrale dans les cancers differencies de la thyroĂŻde. Analyses univariĂ©e et multivariĂ©e
Les cancers papillaires et vĂ©siculaires de la thyroĂŻde sont les cancers endocriniens les plus frĂ©quents. Lâenvahissement ganglionnaire semble peu influencer la survie globale, mais majore les risques de rĂ©cidive locorĂ©gionale et de mĂ©tastases à distance. Cet envahissement est une complication frĂ©quente des cancers papillaires de la thyroĂŻde, moins rapportĂ© dans les cancers vĂ©siculaires. il implique un Ă©videment ganglionnaire qui nâest pas sans risques. Pour dĂ©terminer les moyens de limiter les curages ganglionnaires, nous avons tentĂ© de dĂ©terminer les critĂšres per opĂ©ratoires prĂ©dictifs de mĂ©tastase ganglionnaire centrale et ainsi identifier les patients qui doivent bĂ©nĂ©ficier de cette procĂ©dure. Notre Ă©tude est une Ă©tude rĂ©trospective portant sur 71 patients (49 femmes et 22 hommes) traitĂ©s entre 2000 et 2011dâun cancer diffĂ©renciĂ© de la thyroĂŻde de type papillaire ou vĂ©siculaire. AprĂšs analyse des critĂšres Ă©pidĂ©miologiques, cliniques et anatomopathologiques, nous avons trouvĂ© une association significative entre lâenvahissement extra capsulaire, lâenvahissement ganglionnaire latĂ©ral, la bilatĂ©ralitĂ© et lâenvahissement ganglionnaire central. un Ă©videmment ganglionnaire central prophylactique doit donc ĂȘtre particuliĂšrement considĂ©rĂ© chez ces patients.Mots clĂ©s : carcinome thyroĂŻdien, Ă©videment ganglionnaire, mĂ©tastase ganglionnaire.Papillary and follicular thyroid carcinomas are the most common form of endocrine carcinomas. Lymph node involvement seems to be a low risk factor for death, but it increases the risk for loco-regional recurrences and distant metastasis. Lymph node involvement is a common complication of papillary thyroid carcinoma, less reported in vesicular carcinoma. il involves node dissection and its resulting morbidity. To determine means of limiting lymph node dissections, we attempted to determine intra-operative criteria predictive of node metastasis and soidentify the patients likely to benefit from this procedure. Our study is a retrospective study of 71 patients (49 women and 22 men) treated between 2000 and 2011 from differentiated thyroid cancer (papillary or follicular).After analyses of the demographic, clinical and anatomopathological factors, we found a significant association among extra capsular invasion, lateral lymphnode metastasis, bilaterality, and central compartment lymph node metastasis. A prophylactic neck dissection of the central compartment should be considered particularly in these patients.Keyswords : thyroid carcinoma, lymph node dissection, lymph node metastases
Evaluation des facteurs pronostiques pouvant influencer les resultats dâune septoplastie
Introduction :Une des principales Ă©tiologies de lâobstruction nasale est la dĂ©viation septale, dont le traitement chirurgical est la septoplastie. mais dâautres Ă©tiologies peuvent ĂȘtre Ă lâorigine dâune obstruction nasale, notamment une hypertrophie des cornets, des vĂ©gĂ©tations adĂ©noĂŻdes hypertrophiques, une polypose nasale, etc. Les critĂšres de sĂ©lection sur lesquels se base un chirurgien pour dĂ©cider de pratiquer une septoplastie, sont essentiellement basĂ©s sur lâĂ©valuation clinique. Le but de nĂŽtre travail est dâĂ©valuer ces critĂšres cliniques ainsi que les critĂšres dermographiques pouvant influencer les rĂ©sultats de la septoplastie.Patients et mĂ©thodes : On a Ă©valuĂ© tous les patients qui ont eu une septoplastie dans les 2 Ă 10 derniĂšres annĂ©es. Les donnĂ©es cliniques ont Ă©tĂ© revues afin de prĂ©ciser le siĂšge de la dĂ©formation septale initiale, sa sĂ©vĂ©ritĂ© dictĂ©e par le chirurgien et les rĂ©sultats fonctionnels de la septoplastie.RĂ©sultats et : les patients ayant une dĂ©viation septale antĂ©rieure ont rapportĂ© le plus dâamĂ©lioration aprĂšs septoplastie. Toutefois il ressort de notre Ă©tude quâune sĂ©lection des patients basĂ©e uniquement sur lâĂ©valuation clinique par le chirurgien de lâimportance de la dĂ©viation septale est Ă lâorigine dâun taux important dâinsatisfaction des patientsObjective : a common etiology of nasal obstruction is deviation of the nasal septum, for witch septoplasty is the definitive treatment. But nasal obstruction can be caused by other conditions, such as turbinate hypertrophy, adenoid hypertrophy, and nasal polyposis. The surgeonsâ selection criteria for septoplasty largely rely on clinical judgment alone. The aim of our study was to evaluate if this clinical criteria and the demographics ones could influence the results of septoplasty.Patients and methods :We evaluate all patients who underwent septoplasty in the past 2 to 10 years. Clinical files were reviewed to establish the initial type of septal deformity, its severity dictated by the surgeon and the functional results of septoplasty.Results and Conclusion : Subjects with anterior septal deformities were shown to benefit the most from septoplasty. However, selection of patients based on clinical evaluation alone does carry a considerable risk of patient dissatisfaction with end results
Les cellulites cervico-faciales dâorigine dentaire: a propos de 150 cas
Les cellulites cervico-faciales dâorigine dentaire sont des infections des tissus cellulo-adipeux, de la face et du cou, ayant des potentialitĂ©s extensives pouvant parfois ĂȘtre graves et engager le pronostic vital. Le but de ce travail est dâĂ©tudier le profil Ă©pidĂ©mioclinique et paraclinique de nos patients, dâĂ©valuer leur prise en charge thĂ©rapeutique et leur Ă©volution. Notre Ă©tude est rĂ©trospective et a portĂ© sur 150 cas de cellulites cervico-faciales dâorigine dentaire colligĂ©s sur 10 ans entre 1997 et 2006. La prise en charge thĂ©rapeutique Ă©tait mĂ©dico-hirurgicale. Les cellulites cervico-faciales dâorigine dentaire sont une pathologie potentiellement grave dont la prise en charge est coĂ»teuse et les rĂ©percussions socio-professionnelles et Ă©conomiques sont lourdes dâoĂč lâintĂ©rĂȘt dâune politique de prĂ©vention efficace et ciblĂ©e visant Ă rĂ©duire la morbiditĂ© liĂ©e Ă ces infections.Mots clĂ©s : cellulites cervicale et faciale, infections dentaire, prĂ©vention
Carcinome hybride de la fosse nasale
Hybrid carcinoma is a rare neoplasm, accounting for less than 0.1% of all registered tumors in salivary glands. Up to now, only one case of hybrid carcinoma of the nasal cavity has been described. In this report, we describe a case of hybrid carcinoma composed of epithelial-myoepithelial carcinoma with an adenoid cystic carcinoma component occurring in the nasal cavity in a 56-year-old woman. Caldwell-Luc means resection was performedand the patient revisited because of the tumor recurrence within two years of evolution. A second surgery was accomplished by means of Red Denker and a adjuvant radiation therapy is envisaged. We have not enough detachmentto speak about actual evolution. It is in our knowledge the second case of hybrid tumor of the nasal cavity described in the literature. Hybrid carcinoma of the nasal cavity is possible although rare. Therefore recognition of other component that is more aggressive and has a worse prognosis has therapeutic and prognostic ramifications.Keywords: Carcinoma; hybrid; tumors of nasal cavity
Improved liquid chromatographic method for determination of carotenoids in carrot
Carotenoids are a large class of plant metabolites with a function of either essential nutrients or health promoting compounds for humans. Carrot root is a well-known and significant source of dietary carotenoids, mainly: α- and ÎČ-carotene, lutein and lycopene. These pigments are the main carotenoids separated and quantified routinely by HPLC analysis. However, little is known about minor carotenoids, carotenoid esters and the carotenoids present in leaves despite their potential interest in metabolic and physiological studies. Previous works used C-18 columns but these stationary phases provide a poor resolution of structurally similar compounds and geometrical isomers. In recent years, C-30 columns have been developed and successfully applied at the separation of carotenoids from various plant materials, the number of resolved carotenoids being significantly improved. Based on literature procedures, we have developed a HPLC-DAD method with a C-30 column, adapted to the quantification of carotenoid compounds from carrot roots and leaves. A simple and rapid extraction method was optimized for both these types of samples on a panel of 5 genotypes displaying distinct root colours (different carotenoid composition and contents). Carotenoids from roots were separated in 23 minutes while carotenoids and chlorophylls from leaves were separated in 42 minutes. Compounds were identified according to their retention time and UV-visible spectrum in comparison with authentic standards (analysed individually and in combination, in the same conditions), or with data from literature, when standards were unavailable. Results showed that carrot root exhibited a simple profile with only 1 to 3 main carotenoids whereas a more complex composition was noticed in leaves, containing both identified and unidentified carotenoids and chlorophylls. Moreover, the composition was quite conservative for leaves but depended on the genotype for roots
La baisse de la densitĂ© osseuse au cours des maladies inflammatoires chroniques de lâintestin : prĂ©valence et facteurs de risquĂ©
Introduction: La baisse de la densité minérale osseuse représente la principale manifestation osseuse décrite au cours des maladies inflammatoires chroniques de l'intestin. En Tunisie, trÚs peu d'études ont rapportés sa prévalence et ses facteurs de risque. Le but de ce travail était de déterminer la prévalence de la perte osseuse au cours des maladies inflammatoires chroniques de l'intestin, et rechercher ses facteurs de risque. Méthodes: Patients et méthodes: étude ouverte transversale, réalisée de 2007 jusqu'à 2012. Résultats: 146 cas étaient colligés, dont 105 avaient une maladie de Crohn (71,9%) et 41 avaient une rectocolite hémorragique (28,1%). Il s'agissait de 62 hommes et 84 femmes. L'ùge moyen était de 33,18 ans. La perte osseuse était trouvée chez 85 patients (58,2%). Il s'agissait d'une ostéopénie dans 57 cas et d'ostéoporose dans 28 cas. Les facteurs de risque de perte osseuse étaient une activité physique limitée (p=0,013), un indice de masse corporel '20 kg/m2 (p=0,015), une maladie active (p=0,035), l'étendue de l'atteinte intestinale (p=0,006) et une dose cumulée de corticothérapie dépassant 4,5g de Prednisone (p=0,003). Conclusion: La déminéralisation osseuse est une complication fréquente mais non constante. Ceci justifie un dépistage précoce chez les patients à risque, qui pourront ainsi bénéficier d'un traitement substitutif.Key words: Maladie de Crohn, recto-colite hémorragique, densité minérale osseuse, ostéopénie, ostéoporos
Osteomyelite atypique ou centrale de la base du crane dâorigine sinusienne
Introduction : LâostĂ©omyĂ©litede la base du crĂąne esttypiquement secondaire Ă une otite externe nĂ©crosante chez des patients ĂągĂ©s, diabĂ©tiques. Elle atteint lâos temporal et est habituellement due au pseudomonasaeruginosa. Dans sa forme atypique, lâostĂ©omyĂ©lite atteint les os sphĂ©noĂŻdal ou occipital sans otite externe associĂ©eet est beaucoup moins frĂ©quente. Le but de cette Ă©tude est dâanalyser les caractĂ©ristiques cliniques et de dĂ©terminer les modalitĂ©s thĂ©rapeutiques de lâostĂ©omyĂ©lite nonotologique de la base du crĂąne.MĂ©thodes : Nous avons revu rĂ©trospectivement deux casdâostĂ©omyĂ©lite atypique de la base du crĂąne.RĂ©sultats : Les deux patients se sont prĂ©sentĂ©s dans un tableau dâaltĂ©ration de lâĂ©tat gĂ©nĂ©ral, une asthĂ©nie, des cĂ©phalĂ©es et de la fiĂšvre. Les signes rhinologiques Ă©taient discrets. Aucun des deux patients nâavait de dĂ©ficit neurologique. Lâimagerie avait montrĂ© une destruction osseuse, la biologie a objectivĂ© un syndrome infectieux et une biopsie osseuse trans sphĂ©noĂŻdale a confirmĂ© le diagnostic dâostĂ©omyĂ©lite. Un traitement antibiotique prolongĂ© a Ă©tĂ© instaurĂ© et les deux patients ont Ă©tĂ© guĂ©ris sans rĂ©cidive moyennant un recul de 12 mois.Conclusion : lâatteinte ostĂ©omyĂ©litique centrale de la base du crĂąne est une affection rare dont la prise en charge passe par un prĂ©lĂšvement osseux prĂ©coce et un traitement appropriĂ© afin de prĂ©venir ou limiter dâautres complications telles quâune extension endocrĂąnienne, un empyĂšme, ou la mort.Mots ClĂ©s: OstĂ©omyĂ©lite; Base du crĂąne; sphenoĂŻdite; IRMIntroduction : Skull base osteomyelitis typically arises as a complication of ear infection in older diabetic patients, involves the temporal bone, and has Pseudomonas aeruginosaas the usual pathogen. Atypical skull base osteomyelitis arising from the sphenoid or occipital bones without associated external otitis occurs much less frequently. The purpose of this study was to review the clinical featuresand determine efficacy of treatment for nonotologic osteomyelitis of the skull base.Methods : We retrospectively reviewed two cases of central or atypical skull base osteomyelitis.Results : The two patients presented with asthenia, headache, and fever. No patient presented with neurologic deficits. Contrary to malignant otitis externa, our cases were not preceded by immediate external infections and had normal external ear examinations. One patient had an underlying immunocompromising condition. Imaging demonstrated bone destruction, subsequent microbiological analysis diagnosed infection and a biopsy proved diagnosis of osteomyelitis, a prolonged antibiotic treatment was instored. The two patients were cured with no recurrence of skull base infection over 12-month follow-up period.Conclusion : Central skull base osteomyelitis is a rare disease whose treatment requires an early bone biopsy and appropriate treatment to prevent or limit other complications such as intracranial extension, empyema, or dead.Key Words : Osteomyelitis; Skull base; sphenoĂŻditis; MR
Differential Pigment Accumulation in Carrot Leaves and Roots during Two Growing Periods
Carotenoids are important secondary metabolites involved in plant growth and nutritional quality of vegetable crops. These pigments are highly accumulated in carrot root but the knowledge about the environmental factors on their accumulation is limited. The purpose of this work was to investigate the impact of environmental variations on carotenoid accumulation in carrot leaves and roots. In this work, carrots were grown during two contrasted periods to maximize bioclimatic differences. In leaves, carotenoid and chlorophyll contents were lower in the less favorable growing condition while relative contents were well conserved for all genotypes suggesting a common regulatory mechanism. The down-regulation of all genes under environmental constraints demonstrates that carotenoid accumulation is regulated at transcriptional level. In roots, the decrease in α-carotene and lutein contents was accompanied by an increase of ÎČ-carotene relative content. At transcriptional level, LCYB and ZEP expression increased while LCYE expression decreased in the less favorable condition, suggesting that carotenoid biosynthesis is switched toward the ÎČ-branch
Hopping conduction mechanism and impedance spectroscopy analyses of La0.70Sr0.25Na0.05Mn0.70Ti0.30O3 ceramic
The perovskite sample La0.7Sr0.25Na0.05Mn0.7Ti0.3O3 (LSNM0.70T0.30) was produced via a solid-state route process. The frequency dependence of electrical conduction plot established that according to the Jonscher law. The electrical conduction process was based on both theoretical conduction models assigned to the non-overlapping small polaron tunneling model at low temperatures and correlated barrier hopping mechanism at high temperatures. Detailed investigation of impedance data revealed a non-Debye-type relaxation occurring in the polycrystalline. In addition, the dielectric response confirmed the dominance of the MaxwellâWagner model and Koopâs phenomenological theory effect in conduction phenomenon. The values of permittivity is high for LSNM0.70T0.30 were observed. These values make this composition interesting for microelectric applications. In the thermal study, the relaxation processes observed by electrical conductivity, impedance, and modulus are associated with singly and doubly ionized oxygen vacancies for the lower and higher temperature, respectively. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Majmaah University, MU: R-2021-121The author would like to thank Deanship of Scientific Research at Majmaah University for supporting this work under Project Number No. R-2021-121
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