27,160 research outputs found

    Publications of the planetary biology program for 1976: A special bibliography

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    An annual listing of current publications resulting from research pursued under the auspices of NASA's Planetary Biology Program is presented. To stimulate the exchange of information and ideas among scientists working in the different areas of the program. To facilitate the exchange process. The author of each publication who is presently participating in the program is identified by asterisk. Current addresses for all principal investigators are given in the appendix

    Scientific publications and presentations relating to planetary quarantine. Volume 5: The 1971 supplement

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    A bibliographic compilation, with approximately 200 listings, on planetary quarantine is presented. Also given are scientific publications, and presentations along with an author index

    Scientific publications and presentations relating to planetary quarantine. Volume 5: The 1972 supplement

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    The sixth annual supplement to the bibliography on planetary quarantine contains 191 references, an author index and a permuted title index

    Genome-wide association study for calving performance using high-density genotypes in dairy and beef cattle

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    peer-reviewedBackground Calving difficulty and perinatal mortality are prevalent in modern-day cattle production systems. It is well-established that there is a genetic component to both traits, yet little is known about their underlying genomic architecture, particularly in beef breeds. Therefore, we performed a genome-wide association study using high-density genotypes to elucidate the genomic architecture of these traits and to identify regions of the bovine genome associated with them. Results Genomic regions associated with calving difficulty (direct and maternal) and perinatal mortality were detected using two statistical approaches: (1) single-SNP (single nucleotide polymorphism) regression and (2) a Bayesian approach. Data included high-density genotypes on 770 Holstein-Friesian, 927 Charolais and 963 Limousin bulls. Several novel or previously identified genomic regions were detected but associations differed by breed. For example, two genomic associations, one each on chromosomes 18 and 2 explained 2.49 % and 3.13 % of the genetic variance in direct calving difficulty in the Holstein-Friesian and Charolais populations, respectively. Imputed Holstein-Friesian sequence data was used to refine the genomic regions responsible for significant associations. Several candidate genes on chromosome 18 were identified and four highly significant missense variants were detected within three of these genes (SIGLEC12, CTU1, and ZNF615). Nevertheless, only CTU1 contained a missense variant with a putative impact on direct calving difficulty based on SIFT (0.06) and Polyphen (0.95) scores. Using imputed sequence data, we refined a genomic region on chromosome 4 associated with maternal calving difficulty in the Holstein-Friesian population and found the strongest association with an intronic variant in the PCLO gene. A meta-analysis was performed across the three breeds for each calving performance trait to identify common variants associated with these traits in the three breeds. Our results suggest that a portion of the genetic variation in calving performance is common to all three breeds. Conclusion The genomic architecture of calving performance is complex and mainly influenced by many polymorphisms of small effect. We identified several associations of moderate effect size but the majority were breed-specific, indicating that breed-specific alleles exist for calving performance or that the linkage phase between genotyped allele and causal mutation varies between breeds
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