Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition

Neurons process information by transforming barrages of synaptic inputs into spiking activity. Synaptic inhibition suppresses the output firing activity of a neuron, and is commonly classified as having a subtractive or divisive effect on a neuron's output firing activity. Subtractive inhibition can narrow the range of inputs that evoke spiking activity by eliminating responses to non-preferred inputs. Divisive inhibition is a form of gain control: it modifies firing rates while preserving the range of inputs that evoke firing activity. Since these two "modes" of inhibition have distinct impacts on neural coding, it is important to understand the biophysical mechanisms that distinguish these response profiles. We use simulations and mathematical analysis of a neuron model to find the specific conditions for which inhibitory inputs have subtractive or divisive effects. We identify a novel role for the A-type Potassium current (IA). In our model, this fast-activating, slowly- inactivating outward current acts as a switch between subtractive and divisive inhibition. If IA is strong (large maximal conductance) and fast (activates on a time-scale similar to spike initiation), then inhibition has a subtractive effect on neural firing. In contrast, if IA is weak or insufficiently fast-activating, then inhibition has a divisive effect on neural firing. We explain these findings using dynamical systems methods to define how a spike threshold condition depends on synaptic inputs and IA. Our findings suggest that neurons can "self-regulate" the gain control effects of inhibition via combinations of synaptic plasticity and/or modulation of the conductance and kinetics of A-type Potassium channels. This novel role for IA would add flexibility to neurons and networks, and may relate to recent observations of divisive inhibitory effects on neurons in the nucleus of the solitary tract.Comment: 20 pages, 11 figure

Species Limits and Phylogeography of North American Cricket Frogs (Acris: Hylidae)

Cricket frogs are widely distributed across the eastern United States and two species, the northern cricket frog (Acris crepitans) and the southern cricket frog (A. gryllus) are currently recognized. We generated a phylogenetic hypothesis for Acris using fragments of nuclear and mitochondrial genes in separate and combined phylogenetic analyses. We also used distance methods and fixation indices to evaluate species limits within the genus and the validity of currently recognized subspecies of A. crepitans. The distributions of existing A. crepitans subspecies, defined by morphology and call types, do not match the distributions of evolutionary lineages recovered using our genetic data. We discuss a scenario of call evolution to explain this disparity. We also recovered distinct phylogeographic groups within A. crepitans and A. gryllus that are congruent with other codistributed taxa. Under a lineage-based species concept, we recognize Acris blanchardi as a distinct species. The importance of this revised taxonomy is discussed in light of the dramatic declines in A. blanchardi across the northern and western portions of its range

Suppression of Kelvon-induced decay of quantized vortices in oblate Bose-Einstein Condensates

We study the Kelvin mode excitations on a vortex line in a three-dimensional trapped Bose-Einstein condensate at finite temperature. Our stochastic Gross-Pitaevskii simulations show that the activation of these modes can be suppressed by tightening the confinement along the direction of the vortex line, leading to a strong suppression in the vortex decay rate as the system enters a regime of two-dimensional vortex dynamics. As the system approaches the condensation transition temperature we find that the vortex decay rate is strongly sensitive to dimensionality and temperature, observing a large enhancement for quasi-two-dimensional traps. Three-dimensional simulations of the recent vortex dipole decay experiment of Neely et al. [Phys. Rev. Lett. 104, 160401 (2010)] confirm two-dimensional vortex dynamics, and predict a dipole lifetime consistent with experimental observations and suppression of Kelvon-induced vortex decay in highly oblate condensates.Comment: 8 pages, 8 figure

Axistationary perfect fluids -- a tetrad approach

Stationary axisymmetric perfect fluid space-times are investigated using the curvature description of geometries. Attention is focused on space-times with a vanishing electric part of the Weyl tensor. It is shown that the only incompressible axistationary magnetic perfect fluid is the interior Schwarzschild solution. The existence of a rigidly rotating perfect fluid, generalizing the interior Schwarzschild metric is proven. Theorems are stated on Petrov types and electric/magnetic Weyl tensors.Comment: 12 page

Spin domain formation in spinor Bose-Einstein condensation

The spatial structure of the spinor Bose-Einstein condensates with the spin degrees of freedom is analyzed based on the generalized Gross-Pitaevskii equation (GP) in the light of the present spin domain experiment on m_F=\pm 1, and 0 of the hyperfine state F=1 of ^{23}Na atom gases. The GP solutions in three- and one-spatial dimensional cases reproduce the observed spin domain structures, revealing the length scale associated with the existence of the weak interaction of the spin-spin channel, other than the ordinary coherence length related to the density-density channel. The obtained domain structure in GP is compared with the result in Thomas-Fermi approximation. The former solution is found to better describe the observed features than the latter.Comment: 9 pages, 14 figure

Austral seabirds: challenges and opportunities for research and conservation

This paper draws together the themes of papers on procellariiform biology contained within this special issue of the Papers and Proceedings ofthe Royal Society ofTasmania which is a tribute to Irynej Skira. The role of these birds as generalised biomonitors of marine ecosystem health as well as their important interactions with commercial fisheries and human societies are major considerations. Seabird conservation faces challenges from introduced pest loss of habitat to urban development, marine pollution and climate and oceanographic changes. Studies are hampered by the difficulties of dealing with birds in remote areas (that are therefore expensive to study), a paucity of funds and problems of overlapping national and international jurisdictions in their individual home ranges or on their migration routes. There is a real need for long-term studies ofseabirds because they have delayed breeding systems, a slow rate ofreproduction, long life-spans and high adult survival. Such knowledge is important in understanding their population dynamics, the effects of changing climate, the impacts of commercial fishing, pollution, breeding habitat loss and the harvesting of chicks. The value of the long-term studies of Shorttailed Shearwaters, Puffinus tenuirostris on Fisher Island, Tasmania, is considered in the light of the importance of research investment in basic curiosity-driven research. Neglect of long-term studies and the diminishing role of local scientific journals in the dissemination of baseline data on which to build generalities are the result of changing priorities of government and other funding agencies towards shortterm output-based assessment models. Our present inability to answer the basic question of what determines seabird population abundance and distribution highlights a lack of fundamental population data in Austral seabird research. This must be addressed so that a mixture of comparative, experimental and modelling studies can be mobilised to complement descriptive studies

Elastic and inelastic collisions of 6Li in magnetic and optical traps

We use a full coupled channels method to calculate collisional properties of magnetically or optically trapped ultracold 6Li. The magnetic field dependence of the s-wave scattering lengths of several mixtures of hyperfine states are determined, as are the decay rates due to exchange collisions. In one case, we find Feshbach resonances at B=0.08 T and B=1.98 T. We show that the exact coupled channels calculation is well approximated over the entire range of magnetic fields by a simple analytical calculation.Comment: 4 pages revtex including 4 figures, submitted to PR

Nuclear Magnetic Resonance and Hyperfine Structure

Contains reports on four research projects

Dynamic and Energetic Stabilization of Persistent Currents in Bose-Einstein Condensates

We study conditions under which vortices in a highly oblate harmonically trapped Bose-Einstein condensate (BEC) can be stabilized due to pinning by a blue-detuned Gaussian laser beam, with particular emphasis on the potentially destabilizing effects of laser beam positioning within the BEC. Our approach involves theoretical and numerical exploration of dynamically and energetically stable pinning of vortices with winding number up to $S=6$, in correspondence with experimental observations. Stable pinning is quantified theoretically via Bogoliubov-de Gennes excitation spectrum computations and confirmed via direct numerical simulations for a range of conditions similar to those of experimental observations. The theoretical and numerical results indicate that the pinned winding number, or equivalently the winding number of the superfluid current about the laser beam, decays as a laser beam of fixed intensity moves away from the BEC center. Our theoretical analysis helps explain previous experimental observations, and helps define limits of stable vortex pinning for future experiments involving vortex manipulation by laser beams.Comment: 8 pages 5 figure