133 research outputs found
The Media's Presence During the Execution of a Search Warrant: A Per Se Violation of the Fourth Amendment
The students are our future : growing the next generation of paramedic researchers in Canada
As the paramedic discipline globally moves towards professionalisation through professional registration, higher education, and role diversification within the health service, the importance of the paramedic body of knowledge becomes more apparent. In this article we will outline our experiences with student paramedic research at Fanshawe College, and will expand on our previous reporting of this initiative
frystreet + friends
A performance of the Fry Street Quartet and others at the Performance Hall at Utah State University, performed on November 8, 2012.https://digitalcommons.usu.edu/music_programs/1174/thumbnail.jp
A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face
Precise quantification of atherosclerotic plaque in preclinical models of atherosclerosis requires the volumetric assessment of the lesion(s) while maintaining in situ architecture. Here we use micro-computed tomography (microCT) to detect ex vivo aortic plaque established in three dyslipidemic mouse models of atherosclerosis. All three models lack the low-density lipoprotein receptor (Ldlr−/−), each differing in plaque severity, allowing the evaluation of different plaque volumes using microCT technology. From clearly identified lesions in the thoracic aorta from each model, we were able to determine plaque volume (0.04–3.1 mm3), intimal surface area (0.5–30 mm2), and maximum plaque (intimal-medial) thickness (0.1–0.7 mm). Further, quantification of aortic volume allowed calculation of vessel occlusion by the plaque. To validate microCT for future preclinical studies, we compared microCT data to intimal surface area (by using en face methodology). Both plaque surface area and plaque volume were in excellent correlation between microCT assessment and en face surface area (r2 = 0.99, p<0.0001 and r2 = 0.95, p<0.0001, respectively). MicroCT also identified internal characteristics of the lipid core and fibrous cap, which were confirmed pathologically as Stary type III-V lesions. These data validate the use of microCT technology to provide a more exact empirical measure of ex vivo plaque volume throughout the entire intact aorta in situ for the quantification of atherosclerosis in preclinical models
The evolution of substructure II: linking dynamics to environment
We present results from a series of high-resolution N-body simulations that
focus on the formation and evolution of eight dark matter halos, each of order
a million particles within the virial radius. We follow the time evolution of
hundreds of satellite galaxies with unprecedented time resolution, relating
their physical properties to the differing halo environmental conditions. The
self-consistent cosmological framework in which our analysis was undertaken
allows us to explore satellite disruption within live host potentials, a
natural complement to earlier work conducted within static potentials. Our host
halos were chosen to sample a variety of formation histories, ages, and
triaxialities; despite their obvious differences, we find striking similarities
within the associated substructure populations. Namely, all satellite orbits
follow nearly the same eccentricity distribution with a correlation between
eccentricity and pericentre. We also find that the destruction rate of the
substructure population is nearly independent of the mass, age, and triaxiality
of the host halo. There are, however, subtle differences in the velocity
anisotropy of the satellite distribution. We find that the local velocity bias
at all radii is greater than unity for all halos and this increases as we move
closer to the halo centre, where it varies from 1.1 to 1.4. For the global
velocity bias we find a small but slightly positive bias, although when we
restrict the global velocity bias calculation to satellites that have had at
least one orbit, the bias is essentially removed.Comment: 14 pages, 14 figures, MNRAS in pres
Integrating complementary and alternative medicine into academic medical centers: Experience and perceptions of nine leading centers in North America
BACKGROUND: Patients across North America are using complementary and alternative medicine (CAM) with increasing frequency as part of their management of many different health conditions. The objective of this study was to develop a guide for academic health sciences centers that may wish to consider starting an integrative medicine program. METHODS: We queried North American leaders in the field of integrative medicine to identify initial sites. Key stakeholders at each of the initial sites visited were then asked to identify additional potential study sites (snowball sampling), until no new sites were identified. We conducted structured interviews to identify critical factors associated with success and failure in each of four domains: research, education, clinical care, and administration. During the interviews, field notes were recorded independently by at least two investigators. Team meetings were held after each visit to reach consensus on the information recorded and to ensure that it was as complete as possible. Content analysis techniques were used to identify key themes that emerged from the field notes. RESULTS: We identified ten leading North American integrative medical centers, and visited nine during 2002–2003. The centers visited suggested that the initiation of an integrative medicine program requires a significant initial outlay of funding and a motivated "champion". The centers had important information to share regarding credentialing, medico-legal issues and billing for clinical programs; identifying researchers and research projects for a successful research program; and strategies for implementing flexible educational initiatives and establishing a functional administrative structure. CONCLUSION: Important lessons can be learned from academic integrative programs already in existence. Such initiatives are timely and feasible in a variety of different ways and in a variety of settings
Constraints on the Timing and Extent of Deglacial Grounding Line Retreat in West Antarctica
Projections of Antarctica\u27s contribution to future sea level rise are associated with significant uncertainty, in part because the observational record is too short to capture long-term processes necessary to estimate ice mass changes over societally relevant timescales. Records of grounding line retreat from the geologic past offer an opportunity to extend our observations of these processes beyond the modern record and to gain a more comprehensive understanding of ice-sheet change. Here, we present constraints on the timing and inland extent of deglacial grounding line retreat in the southern Ross Sea, Antarctica, obtained via direct sampling of a subglacial lake located 150 km inland from the modern grounding line and beneath \u3e1 km of ice. Isotopic measurements of water and sediment from the lake enabled us to evaluate how the subglacial microbial community accessed radiocarbon-bearing organic carbon for energy, as well as where it transferred carbon metabolically. Using radiocarbon as a natural tracer, we found that sedimentary organic carbon was microbially translocated to dissolved carbon pools in the subglacial hydrologic system during the 4.5-year period of water accumulation prior to our sampling. This finding indicates that the grounding line along the Siple Coast of West Antarctica retreated more than 250 km inland during the mid-Holocene (6.3 ± 1.0 ka), prior to re-advancing to its modern position
Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells
Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multi-drug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids, which are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stem-like cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs
- …