The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats

Objective: This study aims to evaluate the effect of ellagic acid (EA) by measuring the levels of alveolar bone resorption and inflammatory and oxidative stress markers in the periodontal tissues and serum on the periodontal repair process related to experimental periodontitis in rats. Methodology: Forty Wistar rats were divided into four study groups as follows: Group 1=healthy control (n=10); Group 2=EA control (15 mg/kg)(n=10); Group 3=periodontitis (n=10); Group 4=periodontitis+EA (15 mg/kg) (n=10). The periodontitis model was established by ligating bilateral mandibular first molars for 14 days. Then, rats were given normal saline or EA for another 14 days by gavage administration. Serum and gingiva myeloperoxidase (MPO) activity, 8-hydroxydeoxyguanosine(8-OHdG), and glutathione (GSH) levels were analyzed by ELISA. İmmunohistochemical analysis was used to detect Interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) immunoreactivities in the periodontal tissues. Alveolar bone loss (ABL) and attachment loss (AL) was evaluated by histomorphometry analysis. Results: ABL and AL were statistically higher in group 3 than in groups 1, 2 and 4 and in group 4 than in groups 1 and 2 (p<0.05). MPO activities in gingival tissue and serum were significantly increased in group 3 compared to groups 1 and 2 (p<0.05). Significantly higher serum GSH levels, lower gingiva, and serum 8-OHdG levels, and MPO activity were observed in group 4 compared to group 3 (p<0.05). Rats with periodontitis (group 3) expressed significantly higher immunoreactivities of IL-6 and TNF-α and lower IL-10 immunoreactivity compared to those other groups (p<0.05). IL-6 and TNF-α immunoreactivities significantly decreased and IL-10 immunoreactivity increased in group 4 after the use of EA compared to group 3 (p<0.001). Conclusions: Our findings showed that EA provides significant improvements on gingival oxidative stress and inflammatory markers and alveolar bone resorption in the repair process associated with experimental periodontitis. Therefore, EA may have a therapeutic potential on periodontitis

Granulomatous Anterior Uveitis, Internal Ophthalmoplegia, and Retinal Vasculitis During Chickenpox Disease in A Child

Herein, we report the case of a patient who had granulomatous anterior uveitis, internal ophthalmoplegia, and retinal vasculitis during chickenpox disease. A 9-year-old girl was admitted to our clinic with blurred vision and hyperemia in the right eye. Corrected visual acuity was 20/20 in both eyes. Direct/indirect pupillary reactions were negative in the right eye and pupil was dilated. Biomicroscopic examination revealed middle-sized granulomatous keratic precipitates and a severe anterior chamber reaction. Fundus examination was normal. As there were red papules all over the body she was diagnosed as anterior uveitis secondary to chickenpox and systemic/ topical acyclovir, topical steroid, antihistaminic suspension, isolation, and follow-up were recommended. On day 6, anterior chamber inflammation decreased remarkably, whereas a salt-pepper appearance was observed in the retina. On day 10, a perivascular sheathing was observed, which regressed after 1 month, and her medications were slowly tapered and discontinued. Although anterior uveitis is a common finding after chickenpox, the occurrence of three different involvements is very rare. (Turk J Ophthalmol 2013; 43: 358-61

Granulomatous anterior uveitis, ınternalophthalmoplegia, retinal vasculitis during chickenpox anddisease in a child

Bu olgu sunumunda suçiçeği esnasında granülomatöz ön üveit, internal oftalmopleji ve retinal vaskülit gelişen bir olgu tartışıldıDokuz yaşında bir kız çocuğu sağ gözde bulanık görme ve kızarıklık şikayetiyle tarafımıza başvurdu. Her iki göz düzeltilmiş görme keskinlikleri 20/20 düzeyindeydi. Sağ göz direkt ve indirekt ışık reaksiyonları negatifti ve pupil dilate idi. Biyomikroskopik muayenede sağ göz korneada orta büyüklükte granülomatöz keratik presipitatlar ve ön kamarada yoğun hücre reaksiyonu mevcuttu. Fundus muayenesi normaldi. Hastanın tüm vücudunda kırmızı renkte papüller lezyonları görülmesi üzerine suçiçeğine sekonder granülomatoz ön üveit tanısıyla sistemik ve topikal asiklovir ve steroid, antihistaminik süspansiyon, izolasyon ve günlük takip önerildi. Altıncı günde keratik presipitat ve hücre reaksiyonu azalırken, retinada tuzbiber manzarası izlendi. Onuncu günde retinanın nazal ve temporaperifer kadranlarında görülen perivasküler kılıflanma 4. haftada tamamen geriledi ve ilaçlar azaltılarak kesildi. Suçiçeğinde ön üveit sık görülmesine rağmen, 3 farklı tutulumun görülmesi son derece nadirdir. (Turk J Ophthalmol 2013; 43: 358-61)Herein, we report the case of a patient who had granulomatous anterior uveitis, internal ophthalmoplegia, and retinal vasculitis during chickenpox disease. A 9-year-old girl was admitted to our clinic with blurred vision and hyperemia in the right eye. Corrected visuaacuity was 20/20 in both eyes. Direct/indirect pupillary reactions were negative in the right eye and pupil was dilated. Biomicroscopic examination revealed middle-sized granulomatous keratic precipitates and a severe anterior chamber reaction. Fundus examination was normal. As there were red papules all over the body she was diagnosed as anterior uveitis secondary to chickenpox and systemictopical acyclovir, topical steroid, antihistaminic suspension, isolation, and follow-up were recommended. On day 6, anterior chamber inflammation decreased remarkably, whereas a salt-pepper appearance was observed in the retina. On day 10, a perivascular sheathing was observed, which regressed after 1 month, and her medications were slowly tapered and discontinued. Although anterior uveitis is a common finding after chickenpox, the occurrence of three different involvements is very rare. (Turk J Ophthalmol 2013; 43: 358-61