Tourmaline Composition of the Kı¸sladag Porphyry Au Deposit,Western Turkey: Implication of Epithermal Overprint

The Kışladağ porphyry Au deposit occurs in a middle Miocene magmatic complex comprising three different intrusions and magmatic-hydrothermal brecciation related to the multiphase effects of the different intrusions. Tourmaline occurrences are common throughout the deposit, mostly as an outer alteration rim around the veins with lesser amounts disseminated in the intrusions, and are associated with every phase of mineralization. Tourmaline mineralization has developed as a tourmaline-rich matrix in brecciated zones and tourmaline-quartz and/or tourmaline-sulfide veinlets within the different intrusive rocks. Tourmaline was identified in the tourmaline-bearing breccia zone (TBZ) and intrusive rocks that had undergone potassic, phyllic, and advanced argillic alteration. The tourmaline is present as two morphological varieties, aggregates of fine crystals (rosettes, fan-shaped) and larger isolated crystals and their aggregates. Four tourmaline generations (tourmaline I to IV) have different compositions and substitutions. Tourmaline I in TBZ and INT#1 is distinguished by the highest Fetot and enriched in Fe3+. Tourmalines II and III occur as fine aggregates, accompanied by the formation of isolated crystals and are characterized by lower Fetot and Fe3+. Tourmaline IV is characterized by the lowest Fetot, enriched in Cl, and has the highest proportion of X-site vacancy among all the tourmalines. Tourmaline I may be attributed to the potassic stage in INT#1 and early tourmaline in TBZ. Tourmalines II and III from INT#1 and the TBZ could be referred to the phyllic stage. The low Fe content in tourmaline is caused by the simultaneous deposition of sulfide minerals. Tourmaline IV from the TBZ and tourmaline II from INT#3 are distinguished by the high X-site vacancy proportion up to the formation of X-site vacant species as well as enriched in Cl; they can be attributed to the argillic stage of the hydrothermal process. The textural and especially chemical data of the tourmaline from the Kışladağ Au deposit provide information on the physico-chemical conditions during the porphyry to epithermal transition and subsequent epithermal overprinting

Fluid Inclusion Characteristics of the Kışladağ Porphyry Au Deposit, Western Turkey

The deposit occurs in a mid-Miocene monzonite magmatic complex represented by three different intrusions, namely Intrusion 1 (INT#1), Intrusion 2 (INT#2, INT #2A), and Intrusion 3 (INT#3). Gold mineralization is hosted in all intrusions, but INT#1 is the best mineralized body followed by INT#2. SEM-CL imaging has identified two different veins (V1 and V2) and four distinct generations of quartz formation in the different intrusions. These are: (i) CL-light gray, mosaic-equigranular quartz (Q1), (ii) CL-gray or CL-bright quartz (Q2) that dissolved and was overgrown on Q1, (iii) CL-dark and CL-gray growth zoned quartz (Q3), and (iv) CL-dark or CL-gray micro-fracture quartz fillings (Q4). Fluid inclusion studies show that the gold-hosted early phase Q1 quartz of V1 and V2 veins in INT#1 and INT#2 was precipitated at high temperatures (between 424 and 594 °C). The coexisting and similar ranges of Th values of vapor-rich (low salinity, from 1% to 7% NaCl equiv.) and halite-bearing (high salinity: >30% NaCl) fluid inclusions in Q1 indicates that the magmatic fluid had separated into vapor and high salinity liquid along the appropriate isotherm. Fluid inclusions in Q2 quartz in INT#1 and INT#2 were trapped at lower temperatures between 303 and 380 °C and had lower salinities between 3% and 20% NaCl equiv. The zoned Q3 quartz accompanied by pyrite in V2 veins of both INT#2 and INT#3 precipitated at temperatures between 310 and 373 °C with a salinity range from 5.4% to 10% NaCl eq. The latest generation of fracture filling Q4 quartz, cuts the earlier generations with fluid inclusion Th temperature range from 257 to 333 °C and salinity range from 3% to 12.5% NaCl equiv. The low salinity and low formation temperature of Q4 may be due to the mixing of meteoric water with the hydrothermal system, or late-stage epithermal overprinting. The separation of the magmatic fluid into vapor and aqueous saline pairs in the Q1 quartz of the V1 vein of the INT#1 and INT#2 and CO2-poor fluids indicates the shallow formation of the Kışladağ porphyry gold deposit

Submucosal diclofenac for acute postoperative pain in third molar surgery: A randomized, controlled clinical trial

Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID) for relief of inflammatory pain. A recent formulation combines this drug with hydroxypropyl-β-cyclodextrin (HPβCD) to improve its solubility and to enable subcutaneous administration. Previous studies confirmed the efficacy of this combination. This study’s aim was to evaluate the efficacy, safety, and local tolerability of diclofenac HPβCD administered as a local submucosal injection prior to lower third molar surgery. We conducted a prospective, randomized, double-blind, placebo-controlled, parallel-group phase II single-center study. Seventy-five patients requiring mandibular third molar surgery were randomized into 1 of 5 groups: 5 mg/1 mL diclofenac HPβCD, 12.5 mg/1 mL diclofenac HPβCD, 25 mg/1 mL diclofenac HPβCD, 50 mg/1 mL diclofenac HPβCD, or 1 mL placebo. The respective study drug was injected into the mucosal tissue surrounding the surgical site prior to surgery following achievement of local anesthesia. The primary outcome measure was the area under the curve (AUC) of cumulative pain scores from end of surgery to 6 h postsurgery. This demonstrated a global treatment effect between the active groups and placebo, hence confirming the study drug’s efficacy (P = 0.0126). Secondary outcome measures included the time until onset of pain and the time until patients required rescue medication, both showing statistical significance of the study drug compared to placebo (P < 0.0161 and P < 0.0001, respectively). The time until rescue medication ranged between 7.8 h (for 25 mg/1 mL diclofenac HPβCD) and 16 h (for 50 mg/1 mL diclofenac HPβCD). Interestingly, the 5-mg/1-mL solution appeared superior to the 12.5-mg/1-mL and 25-mg/1-mL solutions (time until rescue medication = 12.44 h). A total of 14% of patients experienced minor adverse drug reactions (ADRs), of which 2 cases demonstrated flap necrosis. These resolved without further intervention. The study results overall indicate efficacy, safety, and relative tolerability of diclofenac HPβCD used locally as a submucosal injection prior to third molar surgery (ClinicalTrials.gov NCT01706588)

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients.

Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2. We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS). Thirty DADA2 patients from 12 countries received a total of 38 HCTs. The indications for HCT were BMF, immune cytopenia, malignancy, or immunodeficiency. Median age at HCT was 9 years (range: 2-28 years). The conditioning regimens for the final transplants were myeloablative (n = 20), reduced intensity (n = 8), or non-myeloablative (n = 2). Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). After a median follow-up of 2 years (range: 0.5-16 years), 2-year OS was 97%, and 2-year GvHD-free relapse-free survival was 73%. The hematological and immunological phenotypes resolved, and there were no new vascular events. Plasma ADA2 enzyme activity normalized in 16/17 patients tested. Six patients required more than one HCT. HCT was an effective treatment for DADA2, successfully reversing the refractory cytopenia, as well as the vasculopathy and immunodeficiency. HCT is a definitive cure for DADA2 with &gt; 95% survival

Hematopoietic cell transplantation cures adenosine deaminase 2 deficiency: report on 30 patients

Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-alpha) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2. Methods We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS). Results Thirty DADA2 patients from 12 countries received a total of 38 HCTs. The indications for HCT were BMF, immune cytopenia, malignancy, or immunodeficiency. Median age at HCT was 9 years (range: 2-28 years). The conditioning regimens for the final transplants were myeloablative (n = 20), reduced intensity (n = 8), or non-myeloablative (n = 2). Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). After a median follow-up of 2 years (range: 0.5-16 years), 2-year OS was 97%, and 2-year GvHD-free relapse-free survival was 73%. The hematological and immunological phenotypes resolved, and there were no new vascular events. Plasma ADA2 enzyme activity normalized in 16/17 patients tested. Six patients required more than one HCT. Conclusion HCT was an effective treatment for DADA2, successfully reversing the refractory cytopenia, as well as the vasculopathy and immunodeficiency. Clinical Implications HCT is a definitive cure for DADA2 with > 95% survival.Transplantation and immunomodulatio

Tourmaline composition of the kışladağ porphyry au deposit, Western Turkey: Implication of epithermal overprint

The Kışladağ porphyry Au deposit occurs in a middle Miocene magmatic complex comprising three different intrusions and magmatic-hydrothermal brecciation related to the multiphase effects of the different intrusions. Tourmaline occurrences are common throughout the deposit, mostly as an outer alteration rim around the veins with lesser amounts disseminated in the intrusions, and are associated with every phase of mineralization. Tourmaline mineralization has developed as a tourmaline-rich matrix in brecciated zones and tourmaline-quartz and/or tourmaline-sulfide veinlets within the different intrusive rocks. Tourmaline was identified in the tourmaline-bearing breccia zone (TBZ) and intrusive rocks that had undergone potassic, phyllic, and advanced argillic alteration. The tourmaline is present as two morphological varieties, aggregates of fine crystals (rosettes, fan-shaped) and larger isolated crystals and their aggregates. Four tourmaline generations (tourmaline I to IV) have different compositions and substitutions. Tourmaline I in TBZ and INT#1 is distinguished by the highest Fetot and enriched in Fe3+. Tourmalines II and III occur as fine aggregates, accompanied by the formation of isolated crystals and are characterized by lower Fetot and Fe3+. Tourmaline IV is characterized by the lowest Fetot, enriched in Cl, and has the highest proportion of X-site vacancy among all the tourmalines. Tourmaline I may be attributed to the potassic stage in INT#1 and early tourmaline in TBZ. Tourmalines II and III from INT#1 and the TBZ could be referred to the phyllic stage. The low Fe content in tourmaline is caused by the simultaneous deposition of sulfide minerals. Tourmaline IV from the TBZ and tourmaline II from INT#3 are distinguished by the high X-site vacancy proportion up to the formation of X-site vacant species as well as enriched in Cl; they can be attributed to the argillic stage of the hydrothermal process. The textural and especially chemical data of the tourmaline from the Kışladağ Au deposit provide information on the physico-chemical conditions during the porphyry to epithermal transition and subsequent epithermal overprinting. © 2020 by the authors. Licensee MDPI, Basel, Switzerland