517 research outputs found
The estimated burden of fungal disease in South Africa
Background. With a population of 56.5 million, over 7 million persons living with HIV, one of the world’s highest rates of tuberculosis (TB) and a large proportion of the population living in poverty, South Africa (SA)’s fungal disease burden is probably substantial and broad in scope.Objectives. To estimate the burden of fungal disease in SA.Methods. Using total and at-risk populations and national, regional and occasionally global data, we estimated the incidence and prevalence of the majority of fungal diseases in SA.Results. Estimates for the annual incidence of HIV-related life-threatening fungal disease include cryptococcal meningitis (8 357 cases), Pneumocystis pneumonia (4 452 cases) and endemic mycoses (emergomycosis, histoplasmosis and blastomycosis, with 100, 60 and 10 cases per year, respectively). We estimate 3 885 cases of invasive aspergillosis annually. The annual burden of candidaemia and Candida peritonitis is estimated at 5 421 and 1 901 cases, respectively. The epidemic of pulmonary TB has probably driven up the prevalence of chronic pulmonary aspergillosis to 99 351 (175.8/100 000), perhaps the highest in the world. Fungal asthma probably affects >100 000 adults. Mucosal candidiasis is common, with an annual prevalence estimated at 828 666 and 135 289 oral and oesophageal cases, respectively, complicating HIV infection alone (estimates in other conditions not made), and over a million women are estimated to be affected by recurrent vulvovaginal candidiasis each year. Tinea capitis in children is common and conservatively estimated at >1 000 000 cases. The inoculation mycoses sporotrichosis, chromoblastomycosis and eumycetoma occur occasionally (with 40, 40 and 10 cases estimated, respectively). Overall, we estimate that over 3.2 million South Africans are afflicted by a fungal disease each year (7.1% of the population).Conclusions. Significant numbers of South Africans are estimated to be affected each year by fungal infections, driven primarily by the syndemics of HIV, TB and poverty. These estimates emphasise the need for better epidemiological data, and for improving the diagnosis and management of these diseases
Influence of Bridge Facility Attributes on Bicycle Travel Behavior
An unlabeled multinomial logit model is developed to estimate the impact bridge facility attributes have on bicycle travel behavior. Data were collected in Austin, Texas, via a GPS-based smartphone application. Three attributes are analyzed and interacted with varied demographic and trip purpose information: bridge accessibility, vehicular volume, and traffic separation. Due to the significant investment in bicycle facilities at the local, state, and federal levels and the increase in urban bicycle use, it is imperative that agencies fully understand the behavioral elements underlying bicycle travel patterns. Transportation planners cannot assume bicyclists are solely focused on minimizing travel time or distance—standard practice assumptions for vehicular modes. This paper focuses on the analysis of bridge characteristics that are attractive to bicyclists. While several others have looked at bicycle facility preferences, this is the first paper to focus exclusively on bridges. Bridge facilities are fundamentally different from the res
Discovery of Five New Pulsars in Archival Data
Reprocessing of the Parkes Multibeam Pulsar Survey has resulted in the
discovery of five previously unknown pulsars and several as-yet-unconfirmed
candidates. PSR J0922-52 has a period of 9.68 ms and a DM of 122.4 pc cm^-3.
PSR J1147-66 has a period of 3.72 ms and a DM of 133.8 pc cm^-3. PSR J1227-6208
has a period of 34.53 ms, a DM of 362.6 pc cm^-3, is in a 6.7 day binary orbit,
and was independently detected in an ongoing high-resolution Parkes survey by
Thornton et al. and also in independent processing by Einstein@Home volunteers.
PSR J1546-59 has a period of 7.80 ms and a DM of 168.3 pc cm^-3. PSR J1725-3853
is an isolated 4.79-ms pulsar with a DM of 158.2 pc cm^-3. These pulsars were
likely missed in earlier processing efforts due to their high DMs and short
periods and the large number of candidates that needed to be looked through.
These discoveries suggest that further pulsars are awaiting discovery in the
multibeam survey data.Comment: 12 pages, 2 figures, 2 tables, accepted to Ap
A GC-MS Method for the Determination of Isoxsuprine in Biological Fluids of the Horse Utilizing Electron Impact Ionization
Isoxsuprine is used to treat navicular disease and other lower-limb problems in the horse. Isoxsuprine is regulated as a class 4 compound by the Association of Racing Commissioners, International (ARCI) and, thus, requires regulatory monitoring. A gas chromatography-mass spectrometry method utilizing electron impact ionization was developed and validated for the quantitation of isoxsuprine in equine plasma or equine urine. The method utilized robotic solid-phase extraction and tri-methyl silyl ether products of derivatization. Products were bis-trimethylsilyl (TMS) isoxsuprine and tris-TMS ritodrine, which released intense quantifier ions m/z 178 for isoxsuprine and m/z 236 for ritodrine that were products of C-C cleavage. To our knowledge, this procedure is faster and more sensitive than other methods in the literature. Concentrations in urine and plasma of isoxsuprine were determined from a calibrator curve that was generated along with unknowns. Ritodrine was used as an internal standard and was, therefore, present in all samples, standards, and blanks. Validation data was also collected. The limit of detection of isoxsuprine in plasma was determined to be 2 ng/mL, the limit of quantitation of isoxsuprine in plasma was determined to be \u3c 5 ng/mL. The mean coefficient of determination for the calibrator curves for plasma was 0.9925 ± 0.0052 and for calibrator curves for urine 0.9904 ± 0.0075. The recovery efficiencies at concentrations of 50, 200, and 300 ng/mL were 76%, 73%, and 76%, respectively, in plasma and 92%, 89% and 91% in urine
An approach to convert vertex-based 3D representations to combinatorial B-splines for real-time visual collaboration
Scientific Visualization and Virtual Reality are increasingly being used for the design of complex systems. These technologies offer powerful capabilities to make decisions that are cost and time effective. The next logical extension is to collaborate with these visual models in real-time, where parts of a design team are geographically separated. Specifically, visual collaboration enables ideas and proposed changes to be discussed exactly on a virtual model of a product. However, high-end visualization hardware and Internet technologies impede widespread use of real-time visual collaboration due to the large amount of data from which these representations are created. These data are typically in the form of 3D vertex-based models, which offer a high degree of realism when displayed, but at a price of storage, rendering speeds and processing efficiency. The more realistic the representation desired, the larger the number of vertices required and hence the higher the file size. In this paper, we propose a new data modeling and handling technique where traditional vertex-based models are converted into combinatorial B-Spline based wire-frame models that allow realtime visual collaboration in the context of typical virtual reality systems. Using appropriate filtering methods, parametric equations are computed for each curved segment in a vertexbased representation and bundled together with sampled linear segments of the model. The computed parametric equation based models occupy only a fraction of the size when compared to the original vertex-based models. These lightweight models can easily be transmitted over the Internet, in real-time, for viewing with a platform independent visual client program. The proposed methods were tested on several example data files to prove the method’s effectiveness
Discovery and Follow-up of Rotating Radio Transients with the Green Bank and LOFAR Telescopes
We have discovered 21 Rotating Radio Transients (RRATs) in data from the
Green Bank Telescope (GBT) 350-MHz Drift-scan and the Green Bank North
Celestial Cap pulsar surveys using a new candidate sifting algorithm. RRATs are
pulsars with sporadic emission that are detected through their bright single
pulses rather than Fourier domain searches. We have developed {\tt RRATtrap}, a
single-pulse sifting algorithm that can be integrated into pulsar survey data
analysis pipelines in order to find RRATs and Fast Radio Bursts. We have
conducted follow-up observations of our newly discovered sources at several
radio frequencies using the GBT and Low Frequency Array (LOFAR), yielding
improved positions and measurements of their periods, dispersion measures, and
burst rates, as well as phase-coherent timing solutions for four of them. The
new RRATs have dispersion measures (DMs) ranging from 15 to 97 pc cm,
periods of 240 ms to 3.4 s, and estimated burst rates of 20 to 400 pulses
hr at 350 MHz. We use this new sample of RRATs to perform statistical
comparisons between RRATs and canonical pulsars in order to shed light on the
relationship between the two populations. We find that the DM and spatial
distributions of the RRATs agree with those of the pulsars found in the same
survey. We find evidence that slower pulsars (i.e. ms) are
preferentially more likely to emit bright single pulses than are faster pulsars
( ms), although this conclusion is tentative. Our results are consistent
with the proposed link between RRATs, transient pulsars, and canonical pulsars
as sources in various parts of the pulse activity spectrum.Comment: 18 pages, 13 figures, 5 tables, published in Ap
Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update.
Quantum polarization tomography of bright squeezed light
We reconstruct the polarization sector of a bright polarization squeezed beam
starting from a complete set of Stokes measurements. Given the symmetry that
underlies the polarization structure of quantum fields, we use the unique SU(2)
Wigner distribution to represent states. In the limit of localized and bright
states, the Wigner function can be approximated by an inverse three-dimensional
Radon transform. We compare this direct reconstruction with the results of a
maximum likelihood estimation, finding an excellent agreement.Comment: 15 pages, 5 figures. Contribution to New Journal of Physics, Focus
Issue on Quantum Tomography. Comments welcom
Student Satisfaction and Performance in an Online Teacher Certification Program
The article presents a study which demonstrates the effectiveness of an online post baccalaureate teacher certification program developed by a Wisconsin university. The case method approach employing multiple methods and multiple data sources were used to investigate the degree to which pre-service teachers were prepared to teach. It was concluded that the study supports online delivery as an effective means of teacher preparation, but it was limited in the number of students followed into their first year of teaching
The Green Bank Northern Celestial Cap Pulsar Survey - I: Survey Description, Data Analysis, and Initial Results
We describe an ongoing search for pulsars and dispersed pulses of radio
emission, such as those from rotating radio transients (RRATs) and fast radio
bursts (FRBs), at 350 MHz using the Green Bank Telescope. With the Green Bank
Ultimate Pulsar Processing Instrument, we record 100 MHz of bandwidth divided
into 4,096 channels every 81.92 . This survey will cover the entire sky
visible to the Green Bank Telescope (, or 82% of the sky)
and outside of the Galactic Plane will be sensitive enough to detect slow
pulsars and low dispersion measure (30 ) millisecond
pulsars (MSPs) with a 0.08 duty cycle down to 1.1 mJy. For pulsars with a
spectral index of 1.6, we will be 2.5 times more sensitive than previous and
ongoing surveys over much of our survey region. Here we describe the survey,
the data analysis pipeline, initial discovery parameters for 62 pulsars, and
timing solutions for 5 new pulsars. PSR J02145222 is an MSP in a long-period
(512 days) orbit and has an optical counterpart identified in archival data.
PSR J06365129 is an MSP in a very short-period (96 minutes) orbit with a
very low mass companion (8 ). PSR J06455158 is an isolated MSP
with a timing residual RMS of 500 ns and has been added to pulsar timing array
experiments. PSR J14347257 is an isolated, intermediate-period pulsar that
has been partially recycled. PSR J18164510 is an eclipsing MSP in a
short-period orbit (8.7 hours) and may have recently completed its spin-up
phase.Comment: 18 pages, 10 figures, 5 tables, accepted by Ap
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