The Solar Neighborhood XXVII: Discovery of New Proper Motion Stars with mu > 0.18 "/yr in the Southern Sky with 16.5 > R_59F > 18.0

Here we present 1584 new southern proper motion systems with mu > 0.18 "/yr and 16.5 > R_59F > 18.0. This search complements the six previous SuperCOSMOS-RECONS (SCR) proper motion searches of the southern sky for stars within the same proper motion range, but with R_59F < 16.5. As in previous papers, we present distance estimates for these systems and find that three systems are estimated to be within 25 pc, including one, SCR 1546-5534, possibly within the RECONS 10 pc horizon at 6.7 pc, making it the second nearest discovery of the searches. We find 97 white dwarf candidates with distance estimates between 10 and 120 pc, as well as 557 cool subdwarf candidates. The subdwarfs found in this paper make up nearly half of the subdwarf systems reported from our SCR searches, and are significantly redder than those discovered thus far. The SCR searches have now found 155 red dwarfs estimated to be within 25 pc, including 10 within 10 pc. In addition, 143 white dwarf candidates and 1155 cool subdwarf candidates have been discovered. The 1584 systems reported here augment the sample of 4724 systems previously discovered in our SCR searches, and imply that additional systems fainter than R_59F = 18.0 are yet to be discovered.Comment: 11 pages of text, seven figure

Semileptonic form factors - a model-independent approach

We demonstrate that the B->D(*) l nu form factors can be accurately predicted given the slope parameter rho^2 of the Isgur-Wise function. Only weak assumptions, consistent with lattice results, on the wavefunction for the light degrees of freedom are required to establish this result. We observe that the QCD and 1/m_Q corrections can be systematically represented by an effective Isgur-Wise function of shifted slope. This greatly simplifies the analysis of semileptonic B decay. We also investigate what the available semileptonic data can tell us about lattice QCD and Heavy Quark Effective Theory. A rigorous identity relating the form factor slope difference rho_D^2-rho_A1^2 to a combination of form factor intercepts is found. The identity provides a means of checking theoretically evaluated intercepts with experiment.Comment: 18 pages, Revtex, 4 postscript figures, uses epsfig.st

The Solar Neighborhood XXV: Discovery of New Proper Motion Stars with 0.40 "/yr > mu > 0.18 "/yr between Declinations -47 degrees and 00 degrees

We present 2817 new southern proper motion systems with 0.40 "/yr > mu > 0.18 "/yr and declination between -47 degrees and 00 degrees. This is a continuation of the SuperCOSMOS-RECONS (SCR) proper motion searches of the southern sky. We use the same photometric relations as previous searches to provide distance estimates based on the assumption that the objects are single main sequence stars. We find 79 new red dwarf systems predicted to be within 25 pc, including a few new components of previously known systems. Two systems - SCR 1731-2452 at 9.5 pc and SCR 1746-3214 at 9.9 pc - are anticipated to be within 10 pc. We also find 23 new white dwarf candidates with distance estimates of 15-66 pc, as well as 360 new red subdwarf candidates. With this search, we complete the SCR sweep of the southern sky for stars with mu > 0.18 "/yr and R_59F < 16.5, resulting in a total of 5042 objects in 4724 previously unreported proper motion systems. Here we provide selected comprehensive lists from our SCR proper motion search to date, including 152 red dwarf systems estimated to be within 25 pc (nine within 10 pc), 46 white dwarfs (ten within 25 pc), and 598 subdwarf candidates. The results of this search suggest that there are more nearby systems to be found at fainter magnitudes and lower proper motion limits than those probed so far.Comment: 47 pages, 16 of text. 7 figure

Newly Developed and Validated Eosinophilic Esophagitis Histology Scoring System and Evidence that it Outperforms Peak Eosinophil Count for Disease Diagnosis and Monitoring

Eosinophilic esophagitis is diagnosed by symptoms, and at least 15 intraepithelial eosinophils per high power field in an esophageal biopsy. Other pathologic features have not been emphasized. We developed a histology scoring system for esophageal biopsies that evaluates eight features: eosinophil density, basal zone hyperplasia, eosinophil abscesses, eosinophil surface layering, dilated intercellular spaces, surface epithelial alteration, dyskeratotic epithelial cells and lamina propria fibrosis. Severity (grade) and extent (stage) of abnormalities were scored using a 4 point scale (0 normal; 3 maximum change). Reliability was demonstrated by strong to moderate agreement among 3 pathologists who scored biopsies independently (p≤0.008). Several features were often abnormal in 201 biopsies (101 distal, 100 proximal) from 104 subjects (34 untreated, 167 treated). Median grade and stage scores were significantly higher in untreated compared to treated subjects (p≤0.0062). Grade scores for features independent of eosinophil counts were significantly higher in biopsies from untreated compared to treated subjects (basal zone hyperplasia p≤0.024 and dilated intercellular spaces p≤0.005), and were strongly correlated (r-square\u3e0.67). Principal components analysis identified 3 principal components that explained 78.2% of the variation in the features. In logistic regression models, 2 principal components more closely associated with treatment status than log distal peak eosinophil count (r-square 17, area under the curve 77.8 vs r-square 9, area under the curve 69.8). In summary, the eosinophilic esophagitis histology scoring system provides a method to objectively assess histologic changes in the esophagus beyond eosinophil number. Importantly, it discriminates treated from untreated patients, uses features commonly found in such biopsies, and is utilizable by pathologists after minimal training. These data provide rationales and a method to evaluate esophageal biopsies for features in addition to peak eosinophil count

Detection of filovirus-reactive antibodies in Australian bat species

Bats have been implicated as the reservoir hosts of filoviruses in Africa, with serological evidence of filoviruses in various bat species identified in other countries. Here, serum samples from 190 bats, comprising 12 different species, collected in Australia were evaluated for filovirus antibodies. An in-house indirect microsphere assay to detect antibodies that cross-react with Ebola virus (Zaire ebolavirus; EBOV) nucleoprotein (NP) followed by an immunofluorescence assay (IFA) were used to confirm immunoreactivity to EBOV and Reston virus (Reston ebolavirus; RESTV). We found 27 of 102 Yinpterochiroptera and 19 of 88 Yangochiroptera samples were positive to EBOV NP in the microsphere assay. Further testing of these NP positive samples by IFA revealed nine bat sera that showed binding to ebolavirus-infected cells. This is the first report of filovirus-reactive antibodies detected in Australian bat species and suggests that novel filoviruses may be circulating in Australian bats

Chandra, HST/STIS, NICER, Swift, and TESS Detail the Flare Evolution of the Repeating Nuclear Transient ASASSN-14ko

ASASSN-14ko is a nuclear transient at the center of the AGN ESO 253-G003 that undergoes periodic flares. Optical flares were first observed in 2014 by the All-Sky Automated Survey for Supernovae (ASAS-SN) and their peak times are well-modeled with a period of $115.2^{+1.3}_{-1.2}$ days and period derivative of $-0.0026 \pm 0.0006$. Here we present ASAS-SN, Chandra, HST/STIS, NICER, Swift, and TESS data for the flares that occurred in December 2020, April 2021, July 2021, and November 2021. The HST/STIS UV spectra evolve from blue shifted broad absorption features to red shifted broad emission features over $\sim$10 days. The Swift UV/optical light curves peaked as predicted by the timing model, but the peak UV luminosities varied between flares and the UV flux in July 2021 was roughly half the brightness of all other peaks. The X-ray luminosities consistently decreased and the spectra became harder during the UV/optical rise but apparently without changes in absorption. Finally, two high-cadence TESS light curves from December 2020 and November 2018 showed that the slopes during the rising and declining phases changed over time, which indicates some stochasticity in the flare's driving mechanism. ASASSN-14ko remains observationally consistent with a repeating partial tidal disruption event, but, these rich multi-wavelength data are in need of a detailed theoretical model.Comment: 25 pages, 14 figures, 4 tables; Submitted to ApJ, comments welcom

Serological evidence of a pararubulavirus and a betacoronavirus in the geographically isolated Christmas Island flying-fox (Pteropus natalis)

Due to their geographical isolation and small populations, insular bats may not be able to maintain acute immunizing viruses that rely on a large population for viral maintenance. Instead, endemic transmission may rely on viruses establishing persistent infections within hosts or inducing only short-lived neutralizing immunity. Therefore, studies on insular populations are valuable for developing broader understanding of viral maintenance in bats. The Christmas Island flying-fox (CIFF; Pteropus natalis) is endemic on Christmas Island, a remote Australian territory, and is an ideal model species to understand viral maintenance in small, geographically isolated bat populations. Serum or plasma (n = 190), oral swabs (n = 199), faeces (n = 31), urine (n = 32) and urine swabs (n = 25) were collected from 228 CIFFs. Samples were tested using multiplex serological and molecular assays, and attempts at virus isolation to determine the presence of paramyxoviruses, betacoronaviruses and Australian bat lyssavirus. Analysis of serological data provides evidence that the species is maintaining a pararubulavirus and a betacoronavirus. There was little serological evidence supporting the presence of active circulation of the other viruses assessed in the present study. No viral nucleic acid was detected and no viruses were isolated. Age-seropositivity results support the hypothesis that geographically isolated bat populations can maintain some paramyxoviruses and coronaviruses. Further studies are required to elucidate infection dynamics and characterize viruses in the CIFF. Lastly, apparent absence of some pathogens could have implications for the conservation of the CIFF if a novel disease were introduced into the population through human carriage or an invasive species. Adopting increased biosecurity protocols for ships porting on Christmas Island and for researchers and bat carers working with flying-foxes are recommended to decrease the risk of pathogen introduction and contribute to the health and conservation of the species

General practitioners' use and experiences of palliative care services: a survey in south east England

<p>Abstract</p> <p>Background</p> <p>The role of the General Practitioner (GP) is central to community palliative care. Good liaison between the different professionals involved in a patient's care is extremely important in palliative care patients. In cases where GPs have previously been dissatisfied with palliative services, this may be seen as a barrier to referral when caring for other patients. The aim of this survey is to investigate the use and previous experiences of GPs of two palliative care services, with particular emphasis on barriers to referral and to explore issues surrounding the GP's role in caring for palliative patients.</p> <p>Methods</p> <p>Design: Descriptive postal survey of use and experience of palliative care services with particular emphasis on barriers to referral. Setting: One Primary Care Trust (PCT), south London, England, population 298,500. Subjects: 180 GPs in the PCT, which is served by two hospice services (A&B).</p> <p>Results</p> <p>An overall questionnaire response rate of 77% (138) was obtained, with 69% (124) used in analysis. Over 90% of GPs were satisfied with the palliative care services over the preceding two years. Two areas of possible improvement emerged; communication and prescribing practices. GPs identified some patients that they had not referred, most commonly when patients or carers were reluctant to accept help, or when other support was deemed sufficient. Over half of the GPs felt there were areas where improvement could be made; with clarification of the rules and responsibilities of the multi disciplinary team being the most common. The majority of GPs were working, and want to work with, the specialist services as part of an extended team. However, a greater number of GPs want to hand over care to the specialist services than are currently doing so.</p> <p>Conclusion</p> <p>A large number of GPs were happy with the service provision of the palliative care services in this area. They suggested that 3 out of 4 terminally ill patients needed specialist input. Views of services were largely positive, and reasons for non referral were unrelated to previous experience of the specialist services.</p

Credible Autocoding of Convex Optimization Algorithms

International audienceThe efficiency of modern optimization methods, coupled with increasing computational resources, has led to the possibility of real-time optimization algorithms acting in safety critical roles. There is a considerable body of mathematical proofs on on-line optimization programs which can be leveraged to assist in the development and verification of their implementation. In this paper, we demonstrate how theoretical proofs of real-time optimization algorithms can be used to describe functional properties at the level of the code, thereby making it accessible for the formal methods community. The running example used in this paper is a generic semi-definite programming (SDP) solver. Semi-definite programs can encode a wide variety of optimization problems and can be solved in polynomial time at a given accuracy. We describe a top-to-down approach that transforms a high-level analysis of the algorithm into useful code annotations. We formulate some general remarks about how such a task can be incorporated into a convex programming autocoder. We then take a first step towards the automatic verification of the optimization program by identifying key issues to be adressed in future work