Assessing infant carriage systems: ground reaction force implications for gait of the caregiver

Objective: To assess the acute alterations of anterior infant carriage systems on the ground reaction force experienced during over ground walking. Background: Previous research has identified the alterations in posture and gait associated with an increased anterior load (external or internal); however the forces applied to the system due to the altered posture during over ground walking have not been established. Method: Thirteen mixed gender participants completed forty-five over ground walking trials at a self-selected pace under three loaded conditions (unloaded, semi-structured carrier 9.9kg and structured carrier 9.9kg). Each trial consisted of a fifteen metre walkway, centred around a piezoelectric force platform sampling at 1200 Hz. Differences were assessed between loaded and unloaded conditions and across carriers using paired samples t-tests and repeated measures ANOVA. Results: Additional load increased all ground reaction force parameters; however, the magnitude of force changes was influenced by carrier structure. The structured carrier displayed increased force magnitudes, a reduction in the time to vertical maximum heel contact and an increased duration of the flat foot phase in walking gait. Conclusion: Evidence suggest that the acute application of anterior infant carriers alters both kinetic and temporal measures of walking gait. Importantly these changes appear to be governed not solely by the additional mass but also by the structure of the carrier. Application: These findings indicate carrier structure should be considered by the wearer and may be used to inform policy in the recommendation of anterior infant carriage systems use by caregivers

Postural stability is affected in older males with Haemophilia—a matched control study

Despite fall-related injuries having serious consequences for older haemophilic patients, few studies have investigated their postural stability and risk of falls. The aim was to examine postural stability, joint function and joint mobility in haemophiliacs and age-matched controls. Centre of pressure excursions in four 60 s balance conditions, two minute walk test, passive ankle and knee range of motion, Haemophilia Joint Health Score, and Haemophilia Early Arthropathy Detection with Ultrasound score were measured in eight men with haemophilia (people with heamophilia, PWH), and eight age-matched men without haemophilia (people without heamophilia, PWOH). PWH have significantly worse postural stability under physically perturbed conditions (p = 0.001–0.028, η2p = 0.19–0.34), reduced joint function (p = 0.001–0.010, d = 1.33–2.62) and mobility (p < 0.001–0.025, d = 1.01–4.61), and increased centre of pressure (CoP) velocity (p < 0.001–0.003) when compared to PWOH. Postural stability among PWH did not deteriorate with time standing, although significant decreases compared to PWOH across all time intervals were observed (Eyes Open Foam (EOF) CoP ellipse (time x group) p = 0.011, η2p = 0.28; path (time × group) p = 0.035, η2p = 0.21; EOF CoP antero-posterior (AP) (time × group) p = 0.021, η2p = 0.24). Joint function, mobility, and postural stability are reduced in PWH compared to PWOH, driven by differences in the CoP AP range. Dynamic tests incorporating physical perturbation may be more effective than static balance tests on a level surface, and longer period of time to assess postural stability may determine whether fatigue affects ability of PWH to maintain postural stability. Adoption of a possible ‘hip strategy’ by which to achieve balance suggests falls prevention programs need to focus on increasing hip strength and retraining ankle strategy movement to allow PWH to improve balance stability

Is Google\u27s Sensorvault Database morally acceptable to use in law enforcement geofence warrants?

November 14, 2019 at 5:30 p.m. in Bryant Hall Room 209. Reception following in the Bryant Hall Rotunda. Through the clear presentation of claims and civil dialogue, we hope to make headway on difficult and pressing questions in our society. Format: Judges\u27 questions and a Q&A will follow the debate between members of the UM Ethics Bowl, with an emphasis on how to address specific claims and arguments civilly for a productive conversation. Sponsored by: Mr. and Mrs. Alfred Hume Bryant Chair of Ethics, The Department of Philosophy and Religion, The Society for Philosophers in America (SOPHIA) dedicated to promoting public discourse and civility.https://egrove.olemiss.edu/greatdebate/1000/thumbnail.jp

The complexity of collaboration: Opportunities and challenges in contracted research

This article explores some of the challenges of utilising collaborative research approaches when undertaking contracted research projects for government and non-government agencies in the adult and community education (ACE) sector. To discuss these challenges, the article draws on three recent examples of research projects undertaken for ACE sector organisations in Aotearoa New Zealand. These challenges include managing relationships with the different parties to the research; dealing with conflicting expectations of funding agencies, commissioning organisations and practitioners; and ownership and dissemination of findings. We highlight the complexity of notions of collaboration and the importance of deliberate trust-building in establishing credibility. We also open up for discussion the thorny issues of who owns the right to disseminate research findings and how far should researchers’ and universities’ responsibilities extend to ensure that research findings are put in the public domain

OCT-Based Macular Structure-Function Correlation in Dependence on Birth Weight and Gestational Age : the Giessen Long-Term ROP Study

Abstract Purpose: To compare retinal layer thicknesses in preterm and term-born children using spectral-domain optical coherence tomography (SD-OCT) and to correlate structure with retinal function. Methods: We performed SD-OCT single and volume scans in the foveal region of premature children aged 6 to 13 years without ROP (no-ROP, n = 100) and with spontaneously regressed ROP (sr-ROP, n = 50) documented with wide-angle digital imaging during routine screening for acute ROP, and 30 age-matched term-born children. Retinal layer segmentation and analysis was performed with custom-made software in single and volume-scans using an Early Treatment of Diabetic Retinopathy Study grid-based method, and compared to light increment sensitivity (LIS) data obtained with a microperimeter at eccentricity points of 0°, 2.8°, and 8°, as previously described. Results: Overall, seven children had to be excluded due to poor image quality (n = 1 no-ROP; n = 2 sr-ROP; n = 4 term). Total retina, ganglion cell + inner plexiform layer (GCL+) and outer nuclear layer + external limiting membrane (ONL+) thickness at the foveal center in no-ROP and sr-ROP were significantly higher compared with term children. Gestational age (GA) and birth weight (BW) were inversely correlated with these layer thicknesses. Rod and cone outer segment length did not differ in either group. The ratio of ONL+ to the whole retina at 0° correlated significantly with reduced LIS. Conclusions: Increased thicknesses of the entire retina or specific layers at the fovea did not correlate with functional loss; but a thinner ONL in retinae without foveal pit did. This reduced ONL+ ratio is potentially caused by a reduced foveal cone density and may be the first morphologic functional correlate in prematurity and ROP

Investigating audible and ultrasonic noise in modern animal facilities

Background: The environmental housing conditions of laboratory animals are important for both welfare and reliable, reproducible data. Guidelines currently exist for factors such as lighting cycles, temperature, humidity, and noise, however, for the latter the current guidelines may overlook important details. In the case of the most common laboratory species, the mouse, the range of frequencies they can hear is far higher than that of humans. The current guidelines briefly mention that ultrasonic (>20 kHz) frequencies can adversely affect mice, and that the acoustic environment should be checked, though no recommendations are provided relating to acceptable levels of ultrasonic noise. Methods: To investigate the ultrasonic environment in a large mouse breeding facility (the Mary Lyon Centre at MRC Harwell), we compared two systems, the Hottinger Bruel and Kjaer PULSE sound analyser, and an Avisoft Bioacoustics system. Potential noise sources were selected; we used the PULSE system to undertake real-time Fourier analysis of noise up to 100 kHz, and the Avisoft system to record noise up to 125 kHz for later analysis. The microphones from both systems were positioned consistently at the same distance from the source and environmental conditions were identical. In order to investigate our result further, a third system, the AudioMoth (Open Acoustic Devices), was also used for recording. We used DeepSqueak software for most of the recording analysis and, in some cases, we also undertook further spectral analysis using RX8 (iZotope, USA). Results: We found that both systems can detect a range of ultrasonic noise sources, and here discuss the benefits and limitations of each approach. Conclusions: We conclude that measuring the acoustic environment of animal facilities, including ultrasonic frequencies that may adversely affect the animals housed, will contribute to minimising disruption to animal welfare and perturbations in scientific research

"Hero Imagery" - Are there performance advantages associated with imagining yourself as your favourite athlete?

Objectives: This study examined whether there are performance advantages associated with a single bout of imagery when imagining yourself ‘as your favourite athlete’, or imagining yourself performing a strength-based task. Design: A blind 2 (Imagery ability: high, low) x 3 (imagery condition: self, “hero”, control) mixed factorial design was used. Methods: Participants (n = 17 male; Mage = 19.7 ± 2.7) completed the Sport Imagery Ability Questionnaire then viewed a standardised video demonstrating the grip strength (GS) task. Three baseline trials separated by one minute were then executed. Three imagery scripts (control, self, hero) were then presented to participants via an MP3 player in a counterbalanced order (an interval of 1-minute was provided between each condition). The conclusion of each imagery script prompted participants to perform the GS task. Performance in each condition was conceptualised as delta change scores (Imagery condition – baseline average). Results: No main effects were present but there was a group x condition interaction (F(2,28) = 4.27, p = .02. ƞ_p^2= .23. The interaction suggests that for individuals with high imagery ability, simply “doing the imagery that they already do” is preferable compared to a scripted self- or hero-imagery condition. For individuals with a low imagery ability, a simple script whether that is self- or hero- based may enhance strength performance, compared to “what they already do”. Conclusion: Imagery ability may influence the effectiveness of a brief imagery intervention. Further examination of processes and outcomes associated with “hero-imagery” is recommended

UA19/17/1/4 Camellia Bowl Media Guide

Media and information guide prepared by the Camellia Bowl Association for teams participating in the championship game. WKU met Louisana Tech on Dec. 15, 1973

Age-Related Hearing Loss

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia. Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate age-related auditory decline. However, a prerequisite for design of therapies is knowledge of the underlying molecular mechanisms. Currently, our understanding of ARHL is very limited. Here, we review recent findings from research into ARHL from both human and animal studies and discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL

Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea

Mammalian cochlear inner hair cells (IHCs) are specialized sensory receptors able to provide dynamic coding of sound signals. This ability is largely conferred by their ribbon synapses, which tether a large number of vesicles at the IHC's presynaptic active zones, allowing high rates of sustained synaptic transmission onto the afferent fibres. How the physiological and morphological properties of ribbon synapses change with age remains largely unknown. Here, we have investigated the biophysical and morphological properties of IHC ribbon synapses in the ageing cochlea (9–12 kHz region) of four mouse strains commonly used in hearing research: early‐onset progressive hearing loss (C57BL/6J and C57BL/6NTac) and ‘good hearing’ strains (C57BL/6NTacCdh23+ and C3H/HeJ). We found that with age, both modiolar and pillar sides of the IHC exhibited a loss of ribbons, but there was an increased volume of those that remained. These morphological changes, which only occurred after 6 months of age, were correlated with the level of hearing loss in the different mouse strains, being most severe for C57BL/6NTac and C57BL/6J, less so for C57BL/6NTacCdh23+ and absent for C3H/HeJ strains. Despite the age‐related reduction in ribbon number in three of the four strains, the size and kinetics of Ca2+‐dependent exocytosis, as well as the replenishment of synaptic vesicles, in IHCs was not affected. The degree of vesicle release at the fewer, but larger, individual remaining ribbon synapses colocalized with the post‐synaptic afferent terminals is likely to increase, indicating the presence of a previously unknown degree of functional compensation in the ageing mouse cochlea