Application of mobile IT in construction

In recent years, the construction industry has been compelled to explore all possible options for improving the delivery of their products and services. Clients are now expecting a better service and projects that meet their requirements more closely. This has challenged the industry to become more efficient, integrated and more attractive, with benefits for its potential workforce and for society as a whole. Information and communication technologies (ICT) are an enabler to facilitate the improvements required for modernisation. However, due to the geographically dispersed and nomadic nature of the construction industry’s workforce, many people are prevented from efficiently and effectively using the ICT tools adopted to date. Mobile technologies providing the ‘last mile’ connection to the point-of activity could be the missing link to help address the ongoing drive for process improvement. Although this has been a well-researched area, several barriers to mainstream adoption still exist: including a perceived lack of suitable devices; a perceived lack of computer literacy; and the perceived high cost. Through extensive industry involvement, this research has taken the theoretical idea that mobile IT use in the construction industry would be beneficial, a step further; demonstrating by means of a state of the art assessment, usability trials, case studies and demonstration projects that the barriers to mainstream adoption can be overcome. The findings of this work have been presented in four peer-reviewed papers. An ongoing dissemination programme is expected to encourage further adoption

Time in the Twelfth Century

Guest editors Sarah Bowden, Lea Braun and George Younge introduce Issue No. 10 of Interfaces: A Journal of Medieval European Literatures, dedicated to the theme of 'Time in the Twelfth Century,' and offer a general overview of the matter and contents of the contributions

History(s) of MEANTIME

This book (Ed. Sarah Bowden), includes an essay by Bowden, and was co-created with artists and participants who were present in the realisation of MEANTIME project-space. There are four further essays by Helen Frosi, Kate Lepper, Neil Chapman and David Stent, and Martin Wooster

Genome-Wide DNA Methylation in Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that causes the enlargement of kidneys due to the bilateral development of fluid-filled cysts. This results in end-stage kidney disease in adults and a reduced life expectancy. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD, the underlying mechanisms causing cystogenesis and allowing the progression of disease are not well understood. As a result of this poor understanding there are few treatment options for patients with ADPKD, therefore a large proportion of patients will progress to end-stage renal disease for which they will need dialysis or renal transplantation. Epigenetic modifications including DNA methylation are known to be altered in neoplasia, for which there are now several FDA-approved therapeutic drugs. As there are many similarities between ADPKD and neoplasia, we postulate that like tumour tissue, ADPKD tissue contains differentially methylated regions that may be exploited for future therapeutic discovery. To investigate this, we have performed reduced representation bisulfite sequencing (RRBS) on four ADPKD kidney tissue samples, and three non-ADPKD kidney tissue samples. In this analysis we confirm that there are 13 regions in the genome with differential methylation, and there is a global trend of hypomethylation in ADPKD. Furthermore, the 3’ end of the PKD associated gene PKD1 shows increased methylation associated with increased mRNA expression. To investigate whether DNA methylation changes are universally changed in ADPKD cysts, we performed RRBS on a further eight ADPKD samples, each from unique cysts from a single ADPKD patient. In this analysis there were differential methylation patterns in each cyst, however these changes were not consistent between cysts. These data show trends in global methylation in ADPKD not previously reported, and methylation changes within the genes NAGLU and GET4 concomitant with gene expression, which require further investigation to identify their role in ADPKD

Implementation and Utilisation of Community-based Mortality Surveillance: a case study from Chad

<p>Abstract</p> <p>Background</p> <p>Prospective surveillance is a recognised approach for measuring death rates in humanitarian emergencies. However, there is limited evidence on how such surveillance should optimally be implemented and on how data are actually used by agencies. This case study investigates the implementation and utilisation of mortality surveillance data by Médecins Sans Frontières (MSF) in eastern Chad. We aimed to describe and analyse the community-based mortality surveillance system, trends in mortality data and the utilisation of these data to guide MSF’s operational response.</p> <p>Methods</p> <p>The case study included 5 MSF sites including 2 refugee camps and 3 camps for internally displaced persons (IDPs). Data were obtained through key informant interviews and systematic review of MSF operational reports from 2004–2008.</p> <p>Results</p> <p>Mortality data were collected using community health workers (CHWs). Mortality generally decreased progressively. In Farchana and Breidjing refugee camps, crude death rates (CDR) decreased from 0.9 deaths per 10,000 person-days in 2004 to 0.2 in 2008 and from 0.7 to 0.1, respectively. In Gassire, Ade and Kerfi IDP camps, CDR decreased from 0.4 to 0.04, 0.3 to 0.04 and 1.0 to 0.3. Death rates among children under 5 years (U5DR) followed similar trends. CDR and U5DR crossed emergency thresholds in one site, Kerfi, where CDR rapidly rose to 2.1 and U5DR to 7.9 in July 2008 before rapidly decreasing to below emergency levels by September 2008.</p> <p>Discussion</p> <p>Mortality data were used regularly to monitor population health status and on two occasions as a tool for advocacy. Lessons learned included the need for improved population estimates and standardized reporting procedures for improved data quality and dissemination; the importance of a simple and flexible model for data collection; and greater investment in supervising CHWs.</p> <p>Conclusions</p> <p>This model of community based mortality surveillance can be adapted and used by humanitarian agencies working in complex settings. Humanitarian organisations should however endeavour to disseminate routinely collected mortality data and improve utilisation of data for operational planning and evaluation. Accurate population estimation continues to be a challenge, limiting the accuracy of mortality estimates.</p

The 2017 Vermont Opioid Prescribing Rules: Prescriber Attitudes

Introduction. In July of 2017, Vermont enacted new rules on acute opioid pre- scribing to reduce misuse, addiction, and overdose associated with prescription opioids. The new rules include requirements of non-opioid therapy use when possible, querying VPMS, patient education and informed consent, and co-prescription of naloxone. Our study objective was to gain insight into the perspectives of opioid prescribers on the new rules. Methods. The 17-item survey included closed and open-ended questions addressing prescriber perceptions about the new rules as well as demographic information about respondents. The survey was sent to Vermont-based opioid prescribers via email, to multiple healthcare organizations and professional societies, and through personal contacts. Open-ended responses were categorized using paired reviewers and group consensus, using a grounded theory approach. Results. A total of 431 responses were obtained, with MD/DOs accounting for 65%, APRNs- 14%, DDS/DMD- 7%, PAs-13%, and NDs- 1%. Of the respondents, 75% thought that more restrictive opioid prescribing rules were necessary, 74% felt the new rules would have some positive effect on the opioid crisis, but only 48% were in favor of the new rules. Barriers to implementation included co-prescribing naloxone (50% were unsuccessful), justifying exceptions to rules in medical record (46% unsuc- cessful), considering non-pharmacologic therapies (39% unsuccessful), and adhering to prescription limits (31% unsuccessful). Conclusions. Roll-out of the new rules has been criticized for implementation issues, overall reducing favorability among prescribers. Feedback obtained may be utilized by the Vermont Health Department and by other states to improve current models of opioid prescribing.https://scholarworks.uvm.edu/comphp_gallery/1264/thumbnail.jp

Genetic variation in cervical preinvasive and invasive disease : a genome-wide association study

Background Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to compare genetic variation in women with invasive cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 with that in healthy controls. Methods We did a GWAS in a cohort of unrelated European individuals using data from UK Biobank, a population-based cohort including 273 377 women aged 40-69 years at recruitment between March 13, 2006, and Oct 1, 2010. We used an additive univariate logistic regression model to analyse genetic variants associated with invasive cervical cancer or CIN3. We sought replication of candidate associations in FinnGen, a large independent dataset of 128 123 individuals. We also did a two-sample mendelian randomisation approach to explore the role of risk factors in the genetic risk of cervical cancer. Findings We included 4769 CIN3 and invasive cervical cancer case samples and 145 545 control samples in the GWAS. Of 9 600 464 assayed and imputed single-nucleotide polymorphisms (SNPs), six independent variants were associated with CIN3 and invasive cervical cancer. These included novel loci rs10175462 (PAX8; odds ratio [OR] 0.87, 95% CI 0.84-0.91; p=1.07 x 10(-9)) and rs27069 (CLPTM1L; 0.88, 0.84-0.92; p=2.51 x 10(-9)), and previously reported signals at rs9272050 (HLA-DQA1; 1.27, 1.21-1.32; p=2.51 x 10(-28)), rs6938453 (MICA; 0.79, 0.75-0 .83; p=1.97 x 10-(17)), rs55986091 (HLA-DQB1; 0.66, 0 .60-0.72; p=6.42 x 10-(22)), and rs9266183 (HLA-B; 0.73, 0.64-0.83; p=1.53 x 10(-6)). Three SNPs were replicated in the independent Finnish dataset of 1648 invasive cervical cancer cases: PAX8 (rs10175462; p=0.015), CLPTM1L (rs27069; p=2.54 x 10(-7)), and HLA-DQA1 (rs9272050; p=7.90 x 10(-8)). Mendelian randomisation further supported the complementary role of smoking (OR 2.46, 95% CI 1.64-3.69), older age at first pregnancy (0.80, 0.68-0.95), and number of sexual partners (1.95, 1.44-2.63) in the risk of developing cervical cancer. Interpretation Our results provide new evidence for the genetic susceptibility to cervical cancer, specifically the PAX8, CLPTM1L, and HLA genes, suggesting disruption in apoptotic and immune function pathways. Future studies integrating host and viral, genetic, and epigenetic variation, could further elucidate complex host-viral interactions. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe