Initial results of secukinumab drug survival in patients with psoriasis: A multicentre daily practice cohort study

Interleukin 17-antagonist secukinumab demonstrated high efficacy for treatment of psoriasis in randomized controlled trials. However, performance in daily practice may differ from trials. Drug survival is a comprehensive outcome covering effectiveness and safety, suitable for analyses of daily practice. The aim of this study was to evaluate drug survival of secukinumab in a daily practice psoriasis cohort. Data were collected from 13 hospitals. Drug survival was analysed using Kaplan–Meier survival curves, split for reason of discontinuation. In total, 196 patients were included (83% biologic experienced). Overall, 12 and 18 months drug survival of secukinumab was 76% and 67%, respectively, and was mostly determined by ineffectiveness. There was a trend towards shorter drug survival in women and in biologic experienced patients. Thirteen percent of patients experienced at least one episode of fungal infection. This is one of the first studies of drug survival of secukinumab in patients with psoriasis treated in daily practice

Novel treatment for cheilitis glandularis.

Contains fulltext : 81343.pdf (publisher's version ) (Open Access

Erythrosis pigmentosa mediofacialis: familial occurrence.

Contains fulltext : 80782.pdf (publisher's version ) (Open Access

Dimethylfumaraat en de (immuno) pathogenese van psoriasis

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[Diagnostic images (410) A women with a green toe nail. Chloronychia (green nail syndrome) caused by P. auruginosa],[Diagnostic images (410) A women with a green toe nail. Chloronychia (green nail syndrome) caused by P. auruginosa]

Contains fulltext : 79787.pdf (publisher's version ) (Closed access

Extensive segmental acanthosis nigricans form of epidermal nevus.

Contains fulltext : 88617.pdf (publisher's version ) (Open Access)Eight cases of the acanthosis nigricans form of epidermal nevus have been described in literature. The present case is impressive and has an extensive segmental distribution. Although etiological factors, such as mutations in the FGFR3 gene, are becoming recognized, treatment options remain limited. We present a case of a 14-year-old male with multiple hyperpigmented, hyperkeratotic plaques on the upper body, axillae, and groin with a segmental distribution following Blaschko lines. Histopathological investigation showed aspects of both acanthosis nigricans and epidermal nevus. So far, screening has not revealed any internal abnormalities. As previous cases show a clear association with internal diseases, repetitive screening for internal diseases and syndromes is suggested in the case of the acanthosis nigricans form of epidermal nevus. Treatment of the condition remains a challenge

Löffler syndrome caused by extensive cutaneous larva migrans: A case report and review of the literature

Contains fulltext : 87350.pdf (publisher's version ) (Open Access

Two adjacent nodules on the leg.

Contains fulltext : 87592.pdf (publisher's version ) (Open Access)Poroma is a rare benign neoplasm (derived from the intraepidermal part of the eccrine or apocrine duct), which may clinically mimic malignant tumors such as (amelanotic) malignant melanoma and porocarcinoma. Histopathological examination is the key to the correct diagnosis, which is illustrated in the present case, in which a pigmented basal cell carcinoma and a poroma are in close proximity to each other. Despite a clinical differential diagnosis of melanoma, histopathology showed the typical characteristics of a poroma, a rare but much more favorable tumor. Histopathological features of poroma are discussed

Yellow swelling around the eyes: periocular lymphoma

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