Deciding the Winner of an Arbitrary Finite Poset Game is PSPACE-Complete

A poset game is a two-player game played over a partially ordered set (poset) in which the players alternate choosing an element of the poset, removing it and all elements greater than it. The first player unable to select an element of the poset loses. Polynomial time algorithms exist for certain restricted classes of poset games, such as the game of Nim. However, until recently the complexity of arbitrary finite poset games was only known to exist somewhere between NC^1 and PSPACE. We resolve this discrepancy by showing that deciding the winner of an arbitrary finite poset game is PSPACE-complete. To this end, we give an explicit reduction from Node Kayles, a PSPACE-complete game in which players vie to chose an independent set in a graph

Racial Differences Among LGBT Adults in the US: LGBT Well-Being at the Intersection of Race

This final report in the series, LGBT Well-Being at the Intersection of Race, uses data from the 2012-2017 Gallup Survey and the Generations/Transpop studies to assess whether LGBT people of color (POC) differ from White LGBT people on several areas of health and socioeconomic well-being. We find that more LGBT people of color report economic instability compared to White LGBT people on many indicators. Additionally, disparities for POC LGBT adults persist in the health domain, except for measures of depression where more White LGBT adults report having depression compared with POC LGBT adults. Further, more women of color who identify as LGBT reported living in a low-income household, and experiencing unemployment and food insecurity compared to all other groups. We also found differences in outcomes among LGBT POC on some economic and health indicators. Overall, the series of papers demonstrate that the relationship between race and LGBT status is a complicated one that differs by outcome and racialized group. Regardless of these complexities, the data point to the need for social and policy interventions that address economic and health disparities along racial, gender and LGBT statuses, separately and at their intersection

Economic Potential of Substituting Legumes for Synthetic Nitrogen in Warm Season Perennial Grasses used for Stocker Cattle Grazing

Stocker cattle grazing warm season perennial grasses is an important economic activity in the southern Great Plains. Substantial increases in the price of nitrogen fertilizer is negatively affecting forage producers’ profitability. Two alternative nitrogen management systems that use annual and perennial legumes have been developed for bermudagrass pastures. The goal of the study is to determine if the legumes systems are more profitable than the conventional practice of applying synthetic sources of nitrogen. Results of the two-year grazing study show that the legume systems could not compete economically with the common practice.economics, grazing, legumes, bermudagrass, nitrogen fertilizer, stocker cattle, Crop Production/Industries, Farm Management, Production Economics,

Clinically Significant Gains in Skillful Grasp Coordination by an Individual With Tetraplegia Using an Implanted Brain-Computer Interface With Forearm Transcutaneous Muscle Stimulation

© 2019 American Congress of Rehabilitation Medicine Objective: To demonstrate naturalistic motor control speed, coordinated grasp, and carryover from trained to novel objects by an individual with tetraplegia using a brain-computer interface (BCI)-controlled neuroprosthetic. Design: Phase I trial for an intracortical BCI integrated with forearm functional electrical stimulation (FES). Data reported span postimplant days 137 to 1478. Setting: Tertiary care outpatient rehabilitation center. Participant: A 27-year-old man with C5 class A (on the American Spinal Injury Association Impairment Scale) traumatic spinal cord injury Interventions: After array implantation in his left (dominant) motor cortex, the participant trained with BCI-FES to control dynamic, coordinated forearm, wrist, and hand movements. Main Outcome Measures: Performance on standardized tests of arm motor ability (Graded Redefined Assessment of Strength, Sensibility, and Prehension [GRASSP], Action Research Arm Test [ARAT], Grasp and Release Test [GRT], Box and Block Test), grip myometry, and functional activity measures (Capabilities of Upper Extremity Test [CUE-T], Quadriplegia Index of Function-Short Form [QIF-SF], Spinal Cord Independence Measure–Self-Report [SCIM-SR]) with and without the BCI-FES. Results: With BCI-FES, scores improved from baseline on the following: Grip force (2.9 kg); ARAT cup, cylinders, ball, bar, and blocks; GRT can, fork, peg, weight, and tape; GRASSP strength and prehension (unscrewing lids, pouring from a bottle, transferring pegs); and CUE-T wrist and hand skills. QIF-SF and SCIM-SR eating, grooming, and toileting activities were expected to improve with home use of BCI-FES. Pincer grips and mobility were unaffected. BCI-FES grip skills enabled the participant to play an adapted “Battleship” game and manipulate household objects. Conclusions: Using BCI-FES, the participant performed skillful and coordinated grasps and made clinically significant gains in tests of upper limb function. Practice generalized from training objects to household items and leisure activities. Motor ability improved for palmar, lateral, and tip-to-tip grips. The expects eventual home use to confer greater independence for activities of daily living, consistent with observed neurologic level gains from C5-6 to C7-T1. This marks a critical translational step toward clinical viability for BCI neuroprosthetics

6-O-alkylated 7-deazainosine nucleoside analogues : discovery of potent and selective anti-sleeping sickness agents

African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies. Currently approved therapies all have their specific drawbacks, prompting a search for novel therapeutic agents. T. brucei lacks the enzymes necessary to forge the purine ring from amino acid precursors, rendering them dependent on the uptake and interconversion of host purines. This dependency renders analogues of purines and corresponding nucleosides an interesting source of potential anti-T. brucei agents. In this study, we synthesized and evaluated a series of 7-substituted 7-deazainosine derivatives and found that 6-O-alkylated analogues in particular showed highly promising in vitro activity with EC50 values in the mid-nanomolar range. SAR investigation of the O-alkyl chain showed that antitrypanosomal activity increased, and also cytotoxicity, with alkyl chain length, at least in the linear alkyl chain series. However, this could be attenuated by introducing a terminal branch point, resulting in the highly potent and selective analogues, 36, 37 and 38. No resistance related to transporter-mediated uptake could be identified, earmarking several of these analogues for further in vivo follow-up studies

Effect of maternal panic disorder on mother-child interaction and relation to child anxiety and child self-efficacy

To determine whether mothers with panic disorder with or without agoraphobia interacted differently with their children than normal control mothers, 86 mothers and their adolescents (aged between 13 and 23 years) were observed during a structured play situation. Maternal as well as adolescent anxiety status was assessed according to a structured diagnostic interview. Results showed that mothers with panic disorder/agoraphobia showed more verbal control, were more criticizing and less sensitive during mother-child interaction than mothers without current mental disorders. Moreover, more conflicts were observed between mother and child dyadic interactions when the mother suffered from panic disorder. The comparison of parenting behaviors among anxious and non-anxious children did not reveal any significant differences. These findings support an association between parental over-control and rejection and maternal but not child anxiety and suggest that particularly mother anxiety status is an important determinant of parenting behavior. Finally, an association was found between children’s perceived self-efficacy, parental control and child anxiety symptoms

D-Cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders

The goal of this review is to examine the clinical studies on d-cycloserine, a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure procedures during cognitive behavioral therapy for anxiety disorders. Although cognitive behavioral therapy and anxiolytic medications are more effective than placebo for treating anxiety disorders, there is still considerable room for further improvement. Traditional combination strategies typically yield disappointing results. However, recent studies based on translational research have shown promise to augment the neural circuitry underlying fear extinction with pharmacological means. We discuss the current state of the literature, including inconsistencies of findings and issues concerning the drug mechanism, dosing, and dose timing. D-cycloserine is a promising combination strategy for cognitive behavioral therapy of anxiety disorders by augmenting extinction learning. However, there is also evidence to suggest that d-cycloserine can facilitate reconsolidation of fear memory when exposure procedures are unsuccessful

Interventions sur les facteurs de risque psychosociaux dans la lombalgie aiguë ou subaiguë en soins primaires : revue de littérature

Contexte. La lombalgie chronique est un problème récurrent en médecine générale. Des facteurs psychosociaux semblent impliqués dans le passage à la chronicité. L’objectif principal de cette revue était d’identifier et de décrire les études traitant d’interventions sur des facteurs psychosociaux dans la lombalgie (sub)aiguë en soins primaires. L’objectif secondaire était d’en analyser l’efficacité.Méthode. Une recherche systématique a été réalisée dans les principales bases de données biomédicales, et les articles pertinents ont été sélectionnés. Les caractéristiques des interventions ont été décrites, et les principaux résultats analysés. Résultats. Parmi les 513 études identifiées, 10 ont été retenues. Toutes les interventions comprenaient une part éducationnelle, surtout fondée sur une brochure : le « Back Book ». Certaines reposaient, en plus, sur une thérapie à orientation cognitivo-comportementale. Une autre était centrée sur la coordination en milieu de travail. Dans ces articles, la description des interventions et de la théorie sous-jacente était souvent insuffisante. Leur impact était modeste sur le pronostic des patients. Conclusion. Les recommandations actuelles sur la prise en charge de la lombalgie (sub)aiguë en soins primaires n’intègrent pas encore les résultats de ces études, mais cette revue apporte peu d’arguments pour les modifier en faveur des interventions identifiées. Des interventions plus individualisées pourraient être une autre voie pour améliorer le pronostic des patients ayant des facteurs de risque psychosociaux