17 research outputs found
Essai d’une psychologie politique du peuple Anglais
Emile Boutmy’nin “Essai D’une Psychologie Politique Du Peuple Anglais” Unvanlı Eser-İ Meşhurunun Bazı Havaşi İlavesiyle Tercüme-İ Kamilesidir.
Eserin İç Kapağında "İstanbul Yüksek Öğretmen Okulu Kitaplığı" Ve "İzmir Mekteb-İ Sultanisi Kütübhanesi" İle "İzmir Atatürk Lisesi Kütüphanesi" Mühürleri Vardır
Le Parthenon et le génie grec.
"Publié pour la première fois au commencement de l'année 1870 sous le titre: Philosophie de l'architecture en Grèce."--Pref.Mode of access: Internet
Études de droit constitutionnel : France, Angleterre, États-Units
"Des trois études qui suivent, deux ont été publiées séparément, l'une en 1878, l'autre en 1884."Mode of access: Internet
Studies in constitutional law : France -- England -- United States /
Mode of access: Internet
Evaluation of the Effects of Pasireotide LAR Administration on Lymphocele Prevention after Axillary Node Dissection for Breast Cancer: Results of a Randomized Non-Comparative Phase 2 Study
International audienceObjectiveThe aim of this study was to assess the efficacy (response rate centered on 80%) of a somatostatin analog with high affinity for 4 somatostatin receptors in reducing the postoperative incidence of symptomatic lymphocele formation following total mastectomy with axillary lymph node dissection.SettingThis prospective, double-blind, randomised, placebo-controlled, phase 2 trial was conducted in two secondary care centres.ParticipantsAll female patients for whom mastectomy and axillary lymph node dissection were indicated were eligible for the study, including patients who had received neo-adjuvant chemotherapy. Main exclusion criteria were related to diabetes, cardiac insufficiency, disorder of cardiac conduction or hepatic failure.InterventionsPatients were randomised to receive one injection of either prolonged-release pasireotide 60 mg or placebo (physiological serum), which were administered intramuscularly 7 to 10 days before the scheduled surgery. The study was conducted in a double-blind manner.Primary and Secondary Outcome MeasuresThe primary outcome measure was the percentage of patients who did not develop post-operative axillary symptomatic lymphoceles during the 2 postoperative months. Secondary endpoints were the total quantity of lymph drained, duration and daily volume of drainage and aspirated volumes of lymph.ResultsNinety-one patients were randomised. Ninety patients were evaluable: 42 patients received pasireotide, and 48 patients received placebo. The mean estimated response rate were 62.4% (95% Credibility Interval [CrI]: 48.6%-75.3%) in the treatment group and 50.2% (95% CrI: 37.6%-62.8%) in the placebo group. Overall safety was comparable across groups, and one serious adverse event occurred. In the treatment group, one patient with known insulin-depe*ndent diabetes required hospitalization for hyperglycaemia.ConclusionsWith this phase 2 preliminary study, even if our results indicate a trend towards a reduction in symptomatic lymphocele, pre-operative injection of pasireotide failed to achieve a response rate centered on 80%. Pharmacokinetics analysis suggests that effect of pasireotide could be optimised