A framework for interpolating scattered data using space-filling curves

The analysis of spatial data occurs in many disciplines and covers a wide variety activities. Available techniques for such analysis include spatial interpolation which is useful for tasks such as visualization and imputation. This paper proposes a novel approach to interpolation using space-filling curves. Two simple interpolation methods are described and their ability to interpolate is compared to several interpolation techniques including natural neighbour interpolation. The proposed approach requires a Monte-Carlo step that requires a large number of iterations. However experiments demonstrate that the number of iterations will not change appreciably with larger datasets

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

AbstractOmega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development of the central nervous system are poorly understood. Active microglial engulfment of synapses regulates brain development. Impaired synaptic pruning is associated with several neurodevelopmental disorders. Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development in mice. Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. These findings provide a mechanistic insight into neurodevelopmental defects caused by maternal n-3 PUFAs dietary deficiency.Infrastructure de Recherche Translationnelle pour les Biothérapies en NeurosciencesProgram Initiative d’Excellenc

Chemical Characterization of α-Oxohydrazone Ligation on Colloids: toward Grafting Molecular Addresses onto Biological Vectors

International audienc

Characterisation and modelling of structural bonding at high strain rate

These paper deals with the development of new bonded joint modelling for crash application. A new testing device has been set up on Split Hopkinson bars in order to identify adhesive’s properties in assemblies for high strain rate and for different loading angles. These tests led to the development of a new cohesive element model used for solving nonlinear dynamic problems with an explicit integration time scheme. An example illustrates and justifies the development of such a cohesive element under dynamic loading by a good efficiency and a significant saving in calculation time

Characterisation and modelling of structural bonding at high strain rate

These paper deals with the development of new bonded joint modelling for crash application. A new testing device has been set up on Split Hopkinson bars in order to identify adhesive’s properties in assemblies for high strain rate and for different loading angles. These tests led to the development of a new cohesive element model used for solving nonlinear dynamic problems with an explicit integration time scheme. An example illustrates and justifies the development of such a cohesive element under dynamic loading by a good efficiency and a significant saving in calculation time

Modélisation et caractérisation des joints collés à hautes vitesses de déformation Modeling and characterization of bonded joints at high strain rates

Ce papier traite de la modélisation de joints collés pour les structures soumises à des sollicitations de type crash. Cette nouvelle modélisation basée sur un élément cohésif tient compte du comportement viscoplastique, de l'endommagement ainsi que de la rupture de l'adhésive. Sensible à la vitesse de déformation l'identification du critère de rupture nécessite une base expérimentale allant jusqu'à de très hautes vitesses de déformations. Un nouveau dispositif d'essais a donc été mis en place sur les barres de Hopkinson afin de solliciter des assemblages à haute vitesse et sous différents angles de chargement. <br> This paper deals with the modeling of bonded joints for structures subjected to dynamic crash loading. This new model based on a cohesive element takes into account the viscoelastic behavior, the damage and the failure of the adhesive. Due to the strain rate sensitivity, the identification of failure criterion requires experimental tests, up to very high strain rates. A new testing device has then been set up on the Hopkinson bar in order to load the assemblies with high strain rates and with different angles

Myiase nasale humaine à

Un cas de myiase nasale humaine due à des larves de stades L2 et L3 d'Œstrus ovis a été diagnostiqué à Lille (Nord de la France). L'œstrose est une myiase naso-sinusale du mouton et de la chèvre causée par les stades larvaires de la mouche O. ovis. Cette zoonose est fréquemment rencontrée dans les pays méditerranéens et tropicaux. Les auteurs comparent la pathogénèse chez le mouton et l'homme et discutent l'épidémiologie, la symptomatologie et le traitement de cette myiase chez l'homme