54 research outputs found
Uricosuric Agents in Uremic Sera IDENTIFICATION OF INDOXYL SULFATE AND HIPPURIC ACID
No full textpatients and normal individuals were subjected to gel filtration on Sephadex-G10. The effects of the eluted fractions on the uptake of urate and para-aminohippurate by isolated cortical tubules of rabbit kidney were investigated. According to the origin of the samples, one to three major groups of fractions inhibiting both urate and para-aminohippurate transport were disclosed. The first eluted group occurred for all the samples under study. The second one was demonstrated in both sera and urines from uremic patients but only in urines from normal individuals. The third one was exclusively detected in uremic sera and urines. Among all the compounds identified, only hippuric acid, eluted in the fractions of the second group, was capable of inhibiting the uptake of urate and para-aminohippurate in vitro. Th
Ouabain-insensitive active sodium transport in rat jejunum: Evidence from ATPase activities, Na uptake by basolateral membrane vesicles andin vitro transintestinal transport
No full textSerum indoxyl sulfate as an early marker for detecting chronic cyclosporine nephrotoxicity
No full textImidazoline-guanidinium and α2-adrenergic binding sites in basolateral membranes from human kidney
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