My father, myself, and my muscles:associations between muscle dysmorphia, narcissism and relationship with father among exercising males

Research has yet to examine the associations between muscle dysmorphia (MD), narcissism and relationship with father in a male population. This study aimed to address this. We hypothesized that a negatively experienced relationship with the father for males will lead to an increase in MD symptoms due to undermined self-esteem that stems from a lack of the father as a positive masculine role model. A total of 503 exercising males (Mage = 28.5, SD = 9.6 years) completed self-report measures of MD, narcissism, and relationship with father. Our hypothesized indirect effect model found a negative indirect effect of relationship with father on MD symptoms via vulnerable narcissism, but not via grandiose narcissism. Analysis of individual path coefficients also revealed that a poor relationship with father impacts the development of vulnerable narcissism, but not grandiose narcissism. These findings alert practitioners to the fact that some individuals' MD symptoms may be an attempt to protect the fragile self-esteem central to vulnerable narcissism. Practitioners should consider exploring individuals' feelings and perceptions about their fathers in the treatment of MD. Moreover, future research should build on these findings and explore the observed associations in a longitudinal design to assess the causal model.publishedVersio

COVID-19 risk-mitigation in reopening mass events: population-based observational study for the UK Events Research Programme in Liverpool City Region

OBJECTIVES: To understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission risks, perceived risks and the feasibility of risk mitigations from experimental mass cultural events before coronavirus disease 2019 (COVID-19) restrictions were lifted. DESIGN: Prospective, population-wide observational study. SETTING: Four events (two nightclubs, an outdoor music festival and a business conference) open to Liverpool City Region UK residents, requiring a negative lateral flow test (LFT) within the 36 h before the event, but not requiring social distancing or face-coverings. PARTICIPANTS: A total of 12,256 individuals attending one or more events between 28 April and 2 May 2021. MAIN OUTCOME MEASURES: SARS-CoV-2 infections detected using audience self-swabbed (5-7 days post-event) polymerase chain reaction (PCR) tests, with viral genomic analysis of cases, plus linked National Health Service COVID-19 testing data. Audience experiences were gathered via questionnaires, focus groups and social media. Indoor CO2 concentrations were monitored. RESULTS: A total of 12 PCR-positive cases (likely 4 index, 8 primary or secondary), 10 from the nightclubs. Two further cases had positive LFTs but no PCR. A total of 11,896 (97.1%) participants with scanned tickets were matched to a negative pre-event LFT: 4972 (40.6%) returned a PCR within a week. CO2 concentrations showed areas for improving ventilation at the nightclubs. Population infection rates were low, yet with a concurrent outbreak of >50 linked cases around a local swimming pool without equivalent risk mitigations. Audience anxiety was low and enjoyment high. CONCLUSIONS: We observed minor SARS-CoV-2 transmission and low perceived risks around events when prevalence was low and risk mitigations prominent. Partnership between audiences, event organisers and public health services, supported by information systems with real-time linked data, can improve health security for mass cultural events

COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region

Objectives: To understand SARS-CoV-2 transmission risks, perceived risks, and the feasibility of risk-mitigations from experimental mass cultural events before COVID-19 restrictions were lifted. Design: Prospective, population-wide observational study. Setting: Four events (two nightclubs; outdoor music festival; business conference) open to Liverpool City Region UK residents, requiring a negative lateral flow test (LFT) within the 36 hours before the event, but not requiring social distancing or face-coverings. Participants: 12,256 individuals attending one or more event between 28th April and 2nd May 2021. Main outcome measures: SARS-CoV-2 infections detected using audience self-swabbed (5-7 days post-event) PCR tests, with viral genomic analysis of cases, plus linked NHS COVID-19 testing data. Audience experiences were gathered via questionnaires, focus groups and social media. Indoor CO2 concentrations were monitored. Results: 12 PCR-positive cases (likely 4 index; 8 primary or secondary), 10 from the nightclubs. Two further cases had positive LFTs but no PCR. 11,896 (97.1%) participants with scanned tickets were matched to a negative pre-event LFT: 4972 (40.6%) returned a PCR within a week. CO2 concentrations showed areas for improving ventilation at the nightclubs. Population infection rates were low, yet with a concurrent outbreak of >50 linked cases around a local swimming pool without equivalent risk-mitigations. Audience anxiety was low and enjoyment high. Conclusions: We observed minor SARS-CoV-2 transmission and low perceived risks around events when prevalence was low and risk-mitigations prominent. Partnership between audiences, event organisers and public health services, supported by information systems with real-time linked data can improve health security for mass cultural events.</p

HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19

SARS-CoV-2 infection results in different outcomes ranging from asymptomatic infection to mild or severe disease and death. Reasons for this diversity of outcome include differences in challenge dose, age, gender, comorbidity and host genomic variation. Human leukocyte antigen (HLA) polymorphisms may influence immune response and disease outcome. We investigated the association of HLAII alleles with case definition symptomatic COVID-19, virus-specific antibody and T-cell immunity. A total of 1364 UK healthcare workers (HCWs) were recruited during the first UK SARS-CoV-2 wave and analysed longitudinally, encompassing regular PCR screening for infection, symptom reporting, imputation of HLAII genotype and analysis for antibody and T-cell responses to nucleoprotein (N) and spike (S). Of 272 (20%) HCW who seroconverted, the presence of HLA-DRB1*13:02 was associated with a 6·7-fold increased risk of case definition symptomatic COVID-19. In terms of immune responsiveness, HLA-DRB1*15:02 was associated with lower nucleocapsid T-cell responses. There was no association between DRB1 alleles and anti-spike antibody titres after two COVID vaccine doses. However, HLA DRB1*15:01 was associated with increased spike T-cell responses following both first and second dose vaccination. Trial registration: NCT04318314 and ISRCTN15677965