33 research outputs found
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
Recently,
we reported a novel role for KMO in the pathogenesis
of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase
(KMO) have previously been described as potential treatments for neurodegenerative
conditions and particularly for Huntingtonâs disease. However,
the inhibitors reported to date have insufficient aqueous solubility
relative to their cellular potency to be compatible with the intravenous
(iv) dosing route required in AP. We have identified and optimized
a novel series of high affinity KMO inhibitors with favorable physicochemical
properties. The leading example is exquisitely selective, has low
clearance in two species, prevents lung and kidney damage in a rat
model of acute pancreatitis, and is progressing into preclinical development
P16-23. Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
International audienc
Contribution a la synthese de la colchicine par voie photochimique
SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Quand lâhomme se fait animal, deux cas de mĂ©tamorphose chez Marie de France : Yonec et Bisclavret
En lisant des rĂ©cits de mĂ©tamorphose, le lecteur a rapidement lâimpression de quitter la logique dâune nature dont les lois semblent comme violĂ©es par ces transformations extraordinaires. Au Moyen-Age, la mĂ©tamorphose se situe au croisement de lâhĂ©ritage grĂ©co-latin, diffusĂ© par la voie des traductions ovidiennes, et de lâhĂ©ritage folklorique, constituĂ© dâun ensemble de rĂ©cits transmis par la tradition orale. Marie de France, qui, avec Yonec et Bisclavret, offre dans son recueil de Lais deux ..
PET metabolic imaging of time-dependent reorganization of olfactory cued fear memory networks in rats
International audienc