Analyse des risques liés au poste chargement camion-citerne par la méthode AMDEC NAFTAL CBR 16A EL HARRACH

62 p. : ill. ; 30 cmL'analyse des risques d'un poste de travail consiste à identifier tous les dangers causés par l'activité exercée dans ce poste et qui menacent les personnes, les installations, et l'environnement dans le but de réduire les niveaux de risques. Ce travail vise à analyser les risques liés au poste de " chargement des carburants dans des camions citerne " par la méthode AMDEC, ce travail a été réaliser au sein l'entreprise NAFTAL " centre carburants (CBR) 16A à EL Harrach ". Après avoir analysé les risques liés au poste chargement des camions citerne, des risques sont apparus tels que: incendie, explosions, pollution, chute de hauteur ... etc., l'application de la méthode AMDEC sur les trois systèmes choisis a été réalis

Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue

We would like to express our appreciation to all staff from Diabesity-UGR group (AnaTorrices, DiegoSalagre, and Juan Miguel Leiva) for their technical support and for being attentive to answer our research questions and to AsmaAmalou from Physiopathology-USTHB group for the animal sacrifice assistance. We would also like to express our warmest thanks to NemchaLebaili and her staff from ÉcoleNormaleSupérieure (Kouba, Algiers) for the use of their animal facilities.The following are available online at http://www.mdpi.com/2072-6643/12/8/2185/s1, Table S1: normal chow and cafeteria food items compositions as given by the product manufacturers.Time-restricted feeding (TRF) showed a potent effect in preventing obesity and improving metabolicoutcomes in several animal models of obesity. However, there is, as of yet, scarce evidence concerning its effectiveness against obesogenic challenges that more accurately mimic human Western diets, such as the cafeteria diet. Moreover, the mechanism for its efficacy is poorly understood. White adipose browning has been linked to body weight loss. Herein, we tested whether TRF has the potential to induce browning of inguinal white adipose tissue (iWAT) and to attenuate obesity and associated dyslipidemia in a cafeteria-diet-induced obesity model. Male Wistar rats were fed normal laboratory chow (NC) or cafeteria diet (CAF) for 16 weeks and were subdivided into two groups that were subjected to either ad libitum (ad lib, A) or TRF (R) for 8 h per day. Rats under the TRF regimen had a lower body weight gain and adiposity than the diet-matchedad lib rats, despite equivalent levels of food intake and locomotor activity. In addition, TRF improved the deranged lipid profile (total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c)) and atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), coronary risk index (CRI) in CAF-fed rats. Remarkably, TRF resulted in decreased size of adipocytes and induced emergence of multilocular brown-like adipocytes in iWAT of NC- and CAF-fed rats. Protein expression of browning markers, such as uncoupling protein-1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), were also up-regulated in the iWAToftime-restricted NC- or CAF-fed rats. These findings suggest that a TRF regimen is an effective strategy to improve CAF diet-induced obesity, probably via a mechanismthe involving WAT browning process.Ministerio de Economia y Competitividad (Spain) SAF2016-79794-RErasmus + Mobility Program Dimension Internacional from "European Commission" KA 10

Un modèle de prévision d’incendie des forêts Etude de cas : Wilaya de M’sila

Les incendies des forêts constituent l’un des principaux risques naturels des forêts dans le monde. Dans certains pays et certaines régions, comme par exemple en Méditerranée, il s’agit même du risque naturel le plus important en forêt. En dépit des efforts considérables déployés dans des actions de prévention et d’extinction, les grands incendies de forêt restent des événements récurrents qui ont souvent des interactions avec les infrastructures et les habitations, concernant ainsi de larges franges de la population. L’intelligence artificielle est largement utilisée dans la vie quotidienne et dans de nombreux domaines différents tels que l’industrie, l’automatisation et les systèmes experts, la médecine et la biologie, l’éducation et même les jeux vidéo. L’apprentissage supervisé est l’une des branches les plus importantes et les plus exploitées de l’apprentissage automatique. Grâce à son succès, il a réalisé un saut quantique dans le domaine de l'intelligence artificielle. Par conséquent, il est devenu le domaine le plus important dans le monde de l'informatique. L'apprentissage supervisé est basé sur l’apprentissage et l’acquisition d’expériences. Il simule la façon dont les humains pensent et apprennent. Machine à vecteurs de support (SVM), Classification naïve bayésienne et arbre de décision sont considérés comme l'un des premiers algorithmes d'apprentissage supervisé. Ils ont donné des résultats très efficaces, en particulier dans la classification et la régression. Dans ce travail, nous nous sommes intéressés par la proposition d’une nouvelle approche basée sur une branche d’intelligence artificielle qui est « l’apprentissage supervisée », pour la prédiction du Feu de forêt. Cette approche est basée sur l’utilisation de deux types des algorithmes pré-entraînés : Machine à vecteurs de support (SVM), Classification naïve bayésienne et arbre de décision. Ces modèles peuvent être utilisés comme outils de prévention efficaces dans la gestion des incendies de forêt

Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue

Time-restricted feeding (TRF) showed a potent effect in preventing obesity and improving metabolicoutcomes in several animal models of obesity. However, there is, as of yet, scarce evidence concerning its effectiveness against obesogenic challenges that more accurately mimic human Western diets, such as the cafeteria diet. Moreover, the mechanism for its efficacy is poorly understood. White adipose browning has been linked to body weight loss. Herein, we tested whether TRF has the potential to induce browning of inguinal white adipose tissue (iWAT) and to attenuate obesity and associated dyslipidemia in a cafeteria-diet-induced obesity model. Male Wistar rats were fed normal laboratory chow (NC) or cafeteria diet (CAF) for 16 weeks and were subdivided into two groups that were subjected to either ad libitum (ad lib, A) or TRF (R) for 8 h per day. Rats under the TRF regimen had a lower body weight gain and adiposity than the diet-matchedad lib rats, despite equivalent levels of food intake and locomotor activity. In addition, TRF improved the deranged lipid profile (total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c)) and atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), coronary risk index (CRI) in CAF-fed rats. Remarkably, TRF resulted in decreased size of adipocytes and induced emergence of multilocular brown-like adipocytes in iWAT of NC- and CAF-fed rats. Protein expression of browning markers, such as uncoupling protein-1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), were also up-regulated in the iWAToftime-restricted NC- or CAF-fed rats. These findings suggest that a TRF regimen is an effective strategy to improve CAF diet-induced obesity, probably via a mechanismthe involving WAT browning process.</jats:p

Adult-onset vanishing white matter disease presenting as dementia

Vanishing White Matter Disease (VWMD), also known as Childhood Ataxia with Central Hypomyelination (CACH) is a leukoencephalopathy with an autosomal recessive inheritance. It is caused by mutations in any of the five genes encoding the five subunits of the eukaryotic translational initiation factor 2B (eIF2B). Although VWMD was initially described in young children, it is now well known that it has a wide phenotypic spectrum, affecting people of all ages.VWMD is typically characterized by normal or mildly delayed initial psychomotor development, followed by episodic or chronic neurological deterioration, often provoked by infections or minor head trauma. Neurological signs consist mainly of cerebellar ataxia and spasticity. There is no specific treatment beside the “prevention” of cellular stress. Therefore, early recognition of the diagnosis is important to avoid triggering factors and allow genetic counseling.The reported case describes the clinical and radiological characteristics of a patient with adulthood onset of VWMD, revealed by subcortical dementia.</p

Comparison of the Efficacy of Polyvalent Intravenous Immunoglobulins and Therapeutic Plasma Exchange in Anti-NMDAR Encephalitis in the ICU

International audienceBackground: Anti-N-methyl D-aspartate-receptor encephalitis (anti-NMDARe) is a severe disease with a favorable outcome when immunomodulatory management is started rapidly. The main objective of this study is to compare the early efficacy of the two most frequently used therapeutics, i.e., intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE), in intensive care patients admitted for anti-NMDARe.Methods: This is an observational retrospective study of patients hospitalized in a tertiary medical neurointensive care unit for severe anti-NMDARe. Patients were categorized according to the modality of first-line immunomodulatory therapies associated with corticosteroids: TPE, IVIG, or IVIG followed by TPE. The primary end point was the effectiveness of the first-line immunomodulatory treatment. Treatment was considered effective when no other immunomodulatory therapy was introduced and the patient met the following three conditions: response to simple commands, absence of epileptic seizures, and absence of abnormal movements.Results: Thirty-seven patients were included in the study from January 2007 to December 2022: 8 were treated with TPE alone, 13 were treated with IVIG alone, and 16 were treated with IVIG followed by TPE. Of the 29 patients treated with IVIG, 13 showed improvement, with a median latency to treatment response of 36 days, whereas 16 were switched to TPE, with a median latency to treatment response of 30 days due to a lack of improvement. All eight patients treated with TPE improved, with a latency to treatment response of 31 days. TPE was significantly more effective than IVIG.Conclusions: This study raises the hypothesis that immunotherapies may have differential response rates among patients with NMDARe. Although the retrospective nature of the analysis may be subject to bias and confounding, the potential for therapeutic impact deserves prospective evaluation