GPI 2.0: Performance Evaluation of the Wavefront Sensor's EMCCD

The Gemini Planet Imager (GPI) is a high contrast imaging instrument that aims to detect and characterize extrasolar planets. GPI is being upgraded to GPI 2.0, with several subsystems receiving a re-design to improve the instrument's contrast. To enable observations on fainter targets and increase stability on brighter ones, one of the upgrades is to the adaptive optics system. The current Shack-Hartmann wavefront sensor (WFS) is being replaced by a pyramid WFS with an low-noise electron multiplying CCD (EMCCD). EMCCDs are detectors capable of counting single photon events at high speed and high sensitivity. In this work, we characterize the performance of the HN\"u 240 EMCCD from N\"uv\"u Cameras, which was custom-built for GPI 2.0. The HN\"u 240 EMCCD's characteristics make it well suited for extreme AO: it has low dark current ($<$ 0.01 e-/pix/fr), low readout noise (0.1 e-/pix/fr at a gain of 5000), high quantum efficiency ( 90% at wavelengths from 600-800 nm; 70% from 800-900 nm), and fast readout (up to 3000 fps full frame). Here we present test results on the EMCCD's noise contributors, such as the readout noise, pixel-to-pixel variability and CCD bias. We also tested the linearity and EM gain calibration of the detector. All camera tests were conducted before its integration into the GPI 2.0 PWFS system.Comment: 16 pages, 14 figures. Conference Proceedings for AO4ELT7, held in June 2023 in Avignon, Franc

Depressive symptoms and alcohol correlates among Brazilians aged 14 years and older: a cross-sectional study

Abstract\ud \ud Background\ud The associations between depressive symptoms and alcohol-related disorders, drinking patterns and other characteristics of alcohol use are important public health issues worldwide. This study aims to study these associations in an upper middle-income country, Brazil, and search for related socio-demographic correlations in men and women.\ud \ud \ud Methods\ud A cross-sectional study was conducted between November 2005 and April 2006. The sample of 3,007 participants, selected using a multistage probabilistic sampling method, represents the Brazilian population aged 14 and older. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale and alcohol dependence was assessed using the Composite International Diagnostic Interview. Associations assessed using bi-variate analysis were tested using Rao-Scott measures. Gender specific multinomial logistic regression models were developed.\ud \ud \ud Results\ud Among the participants with alcohol dependence, 46% had depressive symptoms (17.2% mild/moderate and 28.8% major/severe; p < 0.01); 35.8% (p = 0.08) of those with alcohol abuse and 23.9% (p < 0.01) of those with a binge-drinking pattern also had depressive symptoms. Alcohol abstainers and infrequent drinkers had the highest prevalence of major/severe depressive symptoms, whereas frequent heavy drinkers had the lowest prevalence of major/severe depressive symptoms. In women, alcohol dependence and the presence of one or more problems related to alcohol consumption were associated with higher risks of major/severe depressive symptoms. Among men, alcohol dependence and being ≥45 years old were associated with higher risks of major/severe depressive symptoms.\ud \ud \ud Conclusions\ud In Brazil, the prevalence of depressive symptoms is strongly related to alcohol dependence; the strongest association was between major/severe depressive symptoms and alcohol dependence in women. This survey supports the possible association of biopsychosocial distress, alcohol consumption and the prevalence of depressive symptoms in Brazil. Investing in education, social programs, and care for those with alcohol dependence and major/severe depressive symptoms, especially for such women, and the development of alcohol prevention policies may be components of a strategic plan to reduce the prevalence of depression and alcohol problems in Brazil. Such a plan may also promote the socio-economic development of Brazil and other middle-income countries.Brazilian National Secretariat on Drug Policies (SENAD) [grant number 017/2003]

TMT NFIRAOS: adaptive optics system for the Thirty Meter Telescope

NFIRAOS is the first-light adaptive optics system planned for the Thirty Meter Telescope, and is being designed at the National Research Council of Canada's Herzberg Institute of Astrophysics. NFIRAOS is a laser guide star multiconjugate adaptive optics system - a practical approach to providing diffraction limited image quality in the NIR over a 30" field of view, with high sky coverage. This will enable a wide range of TMT science that depends upon the large corrected field of view and high precision astrometry and photometry. We review recent progress developing the design and conducting performance estimates for NFIRAOS

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Present opto-mechanical design status of NFIRAOS

This paper describes the current opto-mechanical design of NFIRAOS (Narrow Field InfraRed Adaptive Optics System) for the Thirty Meter Telescope (TMT). The preliminary design update review for NFIRAOS was successfully held in December 2011, and incremental design progress has since occurred on several fronts. The majority of NFIRAOS is housed within an insulated and cooled enclosure, and operates at -30 C to reduce background emissivity. The cold optomechanics are attached to a space-frame structure, kinematically supported by bipods that penetrate the insulated enclosure. The bipods are attached to an exo-structure at ambient temperature, which also supports up to three client science instruments and a science calibration unit.Peer reviewed: YesNRC publication: Ye

Increasing fire and the decline of fire adapted black spruce in the boreal forest

Intensifying wildfire activity and climate change can drive rapid forest compositional shifts. In boreal North America, black spruce shapes forest flammability and depends on fire for regeneration. This relationship has helped black spruce maintain its dominance through much of the Holocene. However, with climate change and more frequent and severe fires, shifts away from black spruce dominance to broadleaf or pine species are emerging, with implications for ecosystem functions including carbon sequestration, water and energy fluxes, and wildlife habitat. Here, we predict that such reductions in black spruce after fire may already be widespread given current trends in climate and fire. To test this, we synthesize data from 1,538 field sites across boreal North America to evaluate compositional changes in tree species following 58 recent fires (1989 to 2014). While black spruce was resilient following most fires (62%), loss of resilience was common, and spruce regeneration failed completely in 18% of 1,140 black spruce sites. In contrast, postfire regeneration never failed in forests dominated by jack pine, which also possesses an aerial seed bank, or broad-leaved trees. More complete combustion of the soil organic layer, which often occurs in better-drained landscape positions and in dryer duff, promoted compositional changes throughout boreal North America. Forests in western North America, however, were more vulnerable to change due to greater long-term climate moisture deficits. While we find considerable remaining resilience in black spruce forests, predicted increases in climate moisture deficits and fire activity will erode this resilience, pushing the system toward a tipping point that has not been crossed in several thousand years

TMT adaptive optics program status report

We provide an update on the development of the first light adaptive optics systems for the Thirty Meter Telescope (TMT) over the past two years. The first light AO facility for TMT consists of the Narrow Field Infra-Red AO System (NFIRAOS) and the associated Laser Guide Star Facility (LGSF). This order 60 x 60 laser guide star (LGS) multi-conjugate AO (MCAO) architecture will provide uniform, diffraction-limited performance in the J, H, and K bands over 17-30 arc sec diameter fields with 50 per cent sky coverage at the galactic pole, as is required to support TMT science cases. Both NFIRAOS and the LGSF have successfully completed design reviews during the last twelve months. We also report on recent progress in AO component prototyping, control algorithm development, and system performance analysis. \ua9 2012 SPIE.Peer reviewed: YesNRC publication: Ye

GPI 2.0: upgrading the Gemini Planet Imager

International audienc

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P &lt; 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis