Synthèse énantiosélective de l'antifongique PF1163 B et d'analogues

POITIERS-BU Sciences (861942102) / SudocSudocFranceF

Superacid‐Mediated Late‐Stage Aromatic Polydeuteration of Pharmaceuticals

International audienceThe field of medicinal chemistry is currently witnessing a deuterium rush owing to the remarkable properties of this element as bioisoster of hydrogen atom. Aromatic hydrogen isotope exchange (HIE) is one of the most studied strategies nowadays as it promises to access deuterium-modified drugs directly from their non-labeled parents. While most of the recent studies focus on metal-catalyzed C–H activation strategy, the use of superacidic conditions has been largely overlooked. Here, we show that the use of TfOD as reaction medium allows the late-stage polydeuteration of a broad library of pharmaceuticals bearing a wide array of functional groups, complementing existing procedures

Tandem superelectrophilic activation for the regioselective chlorofluorination of recalcitrant allylic amines

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Innenrücktitelbild: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines (Angew. Chem. 1/2017)

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Inside Back Cover: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines (Angew. Chem. Int. Ed. 1/2017)

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Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines

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Cationic polycyclization of ynamides: building up molecular complexity

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