Design and Simulation of Temperature Sensor based on Long Period Grating in Liquid Filled Photonic Crystal Fiber

In this paper, a high sensitivity temperature sensor based on photonic crystal fiber long period grating (PCF-LPG) filled with ethanol is proposed and simulated by full vector finite element method. The relationship between the resonant wavelength shift, and the temperature was analyzed. The results show that the resonant wavelength of the ethanol filled photonic crystal fiber long period grating is proportional linearly with temperature and the highest  sensitivity of  was achieved, which is 90 times higher than that of conventional LPG temperature sensors

Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin: protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial

INTRODUCTION: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has become standard of care for patients with peritoneal metastases of colorectal origin with a low/moderate abdominal disease load. In case of a peritoneal cancer index (PCI) score >20, CRS-HIPEC is not considered to be beneficial. Patients with a PCI >20 are currently offered palliative systemic chemotherapy. Previous studies have shown that systemic chemotherapy is less effective against peritoneal metastases than it is against haematogenous spread of colorectal cancer. It is suggested that patients with peritoneal metastases may benefit from the addition of intraperitoneal chemotherapy to systemic chemotherapy. Aim of this study is to establish the maximum tolerated dose of intraperitoneal irinotecan, added to standard of care systemic therapy for colorectal cancer. Secondary endpoints are to determine the safety and feasibility of this treatment and to establish the pharmacokinetic profile of intraperitoneally administered irinotecan. METHODS AND ANALYSIS: This phase I, '3+3' dose-escalation, study is performed in two Dutch tertiary referral centres. The study population consists of adult pa

Novel Anti-Metastatic Action of Cidofovir Mediated by Inhibition of E6/E7, CXCR4 and Rho/ROCK Signaling in HPV+ Tumor Cells

Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved in metastatic spread remain elusive, but pro-adhesive receptors and their ligands, such as SDF-1α and CXCR4 are implicated. In the present study, we assessed the possible relationship between SDF-1α/CXCR4 signaling, E6/E7 status and the metastatic process. We found that SDF-1α stimulated the invasion of E6/E7-positive cancer cell lines (HeLa and TC-1) in Matrigel though CXCR4 and subsequent Rho/ROCK activation. In pulmonary metastatic foci generated by TC-1 cells IV injection a high proportion of cells expressed membrane-associated CXCR4. In both cases models (in vitro and in vivo) cell adhesion and invasion was abrogated by CXCR4 immunological blockade supporting a contribution of SDF-1α/CXCR4 to the metastatic process. E6 and E7 silencing using stable knock-down and the approved anti-viral agent, Cidofovir decreased CXCR4 gene expression as well as both, constitutive and SDF-1α-induced cell invasion. In addition, Cidofovir inhibited lung metastasis (both adhesion and invasion) supporting contribution of E6 and E7 oncoproteins to the metastatic process. Finally, potential signals activated downstream SDF-1α/CXCR4 and involved in lung homing of E6/E7-expressing tumor cells were investigated. The contribution of the Rho/ROCK pathway was suggested by the inhibitory effect triggered by Cidofovir and further confirmed using Y-27632 (a small molecule ROCK inhibitor). These data suggest a novel and highly translatable therapeutic approach to cervix cancer, by inhibition of adhesion and invasion of circulating HPV-positive tumor cells, using Cidofovir and/or ROCK inhibition

Increased risk of errors in children parenterals - Balance scale:Accurate drug preparation and administration for the child

Een weegbalans kan medicatiefouten bij voor toediening gereedmaken (VTGM) van parenterale geneesmiddelen voor kinderen voorkomen. Deze extra stap in het VTGM-proces kost relatief weinig tijd en zorgt voor een betere kwaliteitsborging

Increased risk of errors in children parenterals - Balance scale:Accurate drug preparation and administration for the child

Een weegbalans kan medicatiefouten bij voor toediening gereedmaken (VTGM) van parenterale geneesmiddelen voor kinderen voorkomen. Deze extra stap in het VTGM-proces kost relatief weinig tijd en zorgt voor een betere kwaliteitsborging

Design and Analysis of a Microstrip Antenna Based on Superconducting Material for Millimeter Wave Applications

In this paper, we present a design and analysis of microstrip antenna based on superconducting material for millimeter wave applications. The proposed antenna is simulated using electromagnetic microwave studio computer simulator CST. The structure is made by two materials: the yttrium barium copper oxide (YBCO) thin film superconductor material as the patch and silicon Si as substrate with permittivity of 11.9. The superconductor material is characterized by a conductivity of 1.62×10⁷ S/m and critical high temperature of 89 K. The simulated results concerning the return loss show that our structure has ultra wide band over 27 to 70 GHz. Low return loss of the superconductor antenna compared with his perfect conductor counterpart is achieved. In addition, good radiation pattern characteristics are obtained in the frequency band of operation. The proposed antenna has also overall size of 3×3 mm², which facilitate its integration in architecture of communications systems

The Vascular Vegetation Populating the Flora in Building Materials of Historic Monuments Cities of the West Central Region of Morocco

6 páginas, 3 figuras y 1 tablaIn the concern of the preservation of the main historic monuments of the cities of Rabat and Sale (Morocco), a botanical study was conducted in 2009. The prospecting of these monuments allowed raising an inventory of the flora populating their building materials, and it has proved that this flora is rich and diversified. Indeed, it consists of 171 adventitious species distributed in 46 botanical families. The most represented families are Asteraceae, Poaceae, Fabaceae, Caryophyllaceae, Geraniaceae, Brassicaceae and Lamiaceae. They supply, to them only 49.7% of the specific size. The annual therophytes and the dicotyledon are dominant with respectively 66.7% and 84.7% of the specific size. Nevertheless, the presence of more than 20 species of trees and perennials constitutes a serious danger for bulwarks walls, especially by the phenomenon of fissuring by the action of the huge roots of these vegetables. These vegetables fitting into are placed on joints or cracks fissures have a chemical action on stones by acids that they release, and also a mechanical action by the growth of roots inside cracks fissures. They remain one of these are one of the important biological factors of the degradation of historic monuments. It is to note that the bulwarks walls of the site of Chella (Roman ruins) present more floral diversity than the other canvassed monuments (91 species) that are 53% of the total size.Peer reviewe

Design and simulation of temperature sensor based on long period grating in liquid filled photonic crystal fiber.

In this paper, a high sensitivity temperature sensor based on Photonic crystal fiber long period grating (PCF-LPG) filled with ethanol is proposed and simulated by full vector finite element method. The relationship between the resonant wavelength shift, and the temperature was analyzed. The results show that the photonic crystal fiber long period grating filled with ethanol are in proportion to the temperature. This measurement is thus applicable as temperature sensor