Individualization of Immunosuppressive Therapy after Solid Organ Transplantation

__Abstract__ When an individual’s kidneys fail, there are three treatment options: hemodialysis, peritoneal dialysis or kidney transplantation. A successful kidney transplantation results in the best patient survival and a better quality of life compared to the two other treatment modalities. Kidney transplantation is therefore the preferred therapy for renal failure. The first deceased donor kidney transplantation in the United States was performed in 1950 by Lawler and colleagues on Ruth Tucker, a 44-year-old woman with polycystic kidney disease. Although the kidney transplant was rejected ten months later because no immunosuppressive therapy was available at the time, the intervening time allowed Tucker’s remaining native kidney (it was an orthotopic transplantation) to recover and she lived for another five years. At the same time in France, Küss, Hamburger, and others also performed a number of kidney transplantations

Unlocking the potential of conservation agriculture for soil carbon sequestration influenced by soil texture and climate: A worldwide systematic review

Conservation Agriculture (CA) systems have gained significant attention as a sustainable cropping approach that not only improves crop yields but also contributes to climate change adaptation and mitigation through enhanced soil organic carbon (SOC) sequestration. However, a comprehensive understanding of the influence of soil texture and climate conditions on SOC sequestration under CA remains limited. To address this knowledge gap, we conducted a systematic review using the PRISMA method, analyzing data from 35 peer-reviewed articles encompassing 71 field experiments and 451 observations worldwide. Our findings demonstrate the substantial positive impact of CA on SOC sequestration, with an overall increase of approximately 78%. Remarkably, only a mere 2% of observations reported neutral effects, while 20% indicated adverse outcomes. Notably, SOC sequestration rates were highest in tropical regions experiencing dry winters, reaching an impressive 2.50 Mg/ha/year in the topsoil layers. Moreover, fine and moderate textured soils, such as clay, clay loam, loam, and clay sandy, exhibited higher SOC sequestration rates (20-27%) compared to coarse-textured soils dominated by sandy proportions (9%). These findings emphasize the significance of climate conditions and soil texture in shaping the impact of CA on SOC sequestration

Calibration and validation of APSIM-Wheat Model in Mediterranean areas

The Agricultural Production Systems sIMulator-Wheat (APSIM-Wheat) model is one of the most widely used agricultural models. It is a powerful simulator that has been successfully calibrated and tested for many locations in the world, especially in Western Australia (WA). However, there is a noticeable lack of a standard guide for realizing the calibration validation of APSIM-Wheat that could be applied in areas with a Mediterranean climate similar to that of WA. Therefore, this study aims to examine crop simulations reported in published articles and to provide a detailed description of input data and statistical assessment, which represent the two main components of the calibration-validation protocols. The PRISMA (PREFERRED Reporting Items for Systematic Reviews and Meta-Analyses) method was used to identify and select relevant papers for this review. Following the analysis of 31 calibration protocols extracted from selected eligible articles, it was found that regardless of the objective of using APSIM-Wheat, the same category of data is required for calibration. As far as meteorological data is concerned, the information essential to this study was daily maximum and minimum air temperatures, rainfall (mm), and solar radiation. In the case of soil data, information about the texture and hydraulic characteristics, especially PAWC, DUL and LL was required. Regarding agricultural management data, this pertains to cultivated crops, Nitrogen fertilization (rate and time of application) and sowing (date and density). For the statistical evaluation, it was observed that 90 percent of studies analyzed in this review revealed the use of RMSE

Design and Simulation of Temperature Sensor based on Long Period Grating in Liquid Filled Photonic Crystal Fiber

In this paper, a high sensitivity temperature sensor based on photonic crystal fiber long period grating (PCF-LPG) filled with ethanol is proposed and simulated by full vector finite element method. The relationship between the resonant wavelength shift, and the temperature was analyzed. The results show that the resonant wavelength of the ethanol filled photonic crystal fiber long period grating is proportional linearly with temperature and the highest  sensitivity of  was achieved, which is 90 times higher than that of conventional LPG temperature sensors

Phytoremediation study of mining soils: case of the Mibladen and Zaida mine (High Moulouya, Morocco)

The Upper Moulouya region, including the Mibladen (M) and Zaïda (Z) mines, is one of the highest lead (Pb) deposit areas in Morocco. These mines, abandoned without any measure of rehabilitation, constitute the main source of soil pollution by Metallic Trace Elements (MTEs) accumulation in the region. In this study, two greenhouse phytoremediation experiments (for the Mibladen and Zaida sites) were set up using Italian ryegrass (Lolium multiflorum) specie to assess its capacity and ability to remediate soils contaminated by zinc (Zn), cadmium (Cd), copper (Cu), and Pb. For both experiments, various factors including (i) three substrates (waste treatment [Wt]; clay uncovering [Cun]; and unpolluted control soil [Ucs]) and (ii) three treatments (no treatment, treatment with organic matter, and treatment with chemical fertilizers) were studied. The results before planting indicated that Wt substrates had poorer physicochemical properties than those of Cun, thus they are the most exposed to the degradation phenomena. This is confirmed by pollution index (PI) results that revealed the trend of PI (Z Wt)> PI (M wt)> PI (M Cun)> PI (Z Cun)> PI (Z Ucs)> PI (M Ucs). The results of experiments indicated that ryegrass crops can grow on substrates contaminated with MTEs. Depending on the applied fertilizers, available metals, and the type of soil, the phytoremediation results showed that L. multiflorum can tolerate, hyperaccumulate, and translocate MTEs from polluted substrates. Our findings suggest that this plant can be a solution for remediating alkaline soils polluted by Cd, Pb, Zn, and Cu in Mediterranean conditions

Geodiversity Examples of Morocco: From Inventory to Regional Geotourism Development

The soil and subsoil of Morocco are rich in geological phenomena that bear the imprint of a history which goes back in time more than 2000 million years. Very many geologically remarkable sites exposed in accessible outcrops, with good quality remained unknown to the general public and therefore deserved to be vulgarized. It is a memory to acquaint the present generations but also to preserve for future generations. In total, a rich geological heritage in many ways: Varied land- scapes, international stratotypes, various geological structures, varied rocks, mineral associations, a huge procession offossiles, remnants of oceanic crust (ophiolites) among oldests ones in the world (800 my), etc. For this geological heritage, an approach of an overall inventory is needed, both regionally and nationally, taking into account all the skills of the earth sciences. This will put the item on the natural (geological) potentialities as a lever for sustainable regional development. For this, it is necessary to implement a strategy of “geoconservation” for the preservation and as- sessment of the geological heritage. A website “lithothèque du Maroc” is under construction.info:eu-repo/semantics/publishedVersio

Mapa del activismo feminista islámico en la red

El objetivo de este trabajo es confeccionar un mapa del activismo feminista islámico en internet. Para llevarlo a cabo, se realizará una selección de páginas web tanto de activistas como de organizaciones activistas y, a partir de aquí, se procederá a analizar sus contenidos, las lenguas de redacción, los países de origen... Posteriormente, se organizarán y clasificarán según estos datos y también se traducirán las páginas de presentación/"sobre nosotros" de algunas de las páginas que sean representativos del mapa que ofrecerá el estudio.L'objectiu d'aquest treball és confeccionar un mapa de l'activisme feminista islàmic a Internet. Per dur-lo a terme, es farà un recull de llocs web tant d'activistes com d'organitzacions activistes i, a partir d'aquí, es procedirà a analitzar-ne els continguts, les llengües de redacció, els països d'origen... Posteriorment, s'organitzaran i classificaran segons aquestes dades i també es traduiran les pàgines de presentació/"qui som" d'alguns dels llocs que siguin representatius del mapa que oferirà l'estudi.The main purpose of this research is to make a map of the Islamic feminist activism online. To achieve this purpose, a selection of websites that belong to activists and activist organizations will be made. Their content, languages, countries of origin, etc. will be analysed in order to organize and classify the organisations according to this information. The "about us" section of some of the sites will be translated as well

Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin: protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial

INTRODUCTION: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has become standard of care for patients with peritoneal metastases of colorectal origin with a low/moderate abdominal disease load. In case of a peritoneal cancer index (PCI) score >20, CRS-HIPEC is not considered to be beneficial. Patients with a PCI >20 are currently offered palliative systemic chemotherapy. Previous studies have shown that systemic chemotherapy is less effective against peritoneal metastases than it is against haematogenous spread of colorectal cancer. It is suggested that patients with peritoneal metastases may benefit from the addition of intraperitoneal chemotherapy to systemic chemotherapy. Aim of this study is to establish the maximum tolerated dose of intraperitoneal irinotecan, added to standard of care systemic therapy for colorectal cancer. Secondary endpoints are to determine the safety and feasibility of this treatment and to establish the pharmacokinetic profile of intraperitoneally administered irinotecan. METHODS AND ANALYSIS: This phase I, '3+3' dose-escalation, study is performed in two Dutch tertiary referral centres. The study population consists of adult pa

Novel Anti-Metastatic Action of Cidofovir Mediated by Inhibition of E6/E7, CXCR4 and Rho/ROCK Signaling in HPV+ Tumor Cells

Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved in metastatic spread remain elusive, but pro-adhesive receptors and their ligands, such as SDF-1α and CXCR4 are implicated. In the present study, we assessed the possible relationship between SDF-1α/CXCR4 signaling, E6/E7 status and the metastatic process. We found that SDF-1α stimulated the invasion of E6/E7-positive cancer cell lines (HeLa and TC-1) in Matrigel though CXCR4 and subsequent Rho/ROCK activation. In pulmonary metastatic foci generated by TC-1 cells IV injection a high proportion of cells expressed membrane-associated CXCR4. In both cases models (in vitro and in vivo) cell adhesion and invasion was abrogated by CXCR4 immunological blockade supporting a contribution of SDF-1α/CXCR4 to the metastatic process. E6 and E7 silencing using stable knock-down and the approved anti-viral agent, Cidofovir decreased CXCR4 gene expression as well as both, constitutive and SDF-1α-induced cell invasion. In addition, Cidofovir inhibited lung metastasis (both adhesion and invasion) supporting contribution of E6 and E7 oncoproteins to the metastatic process. Finally, potential signals activated downstream SDF-1α/CXCR4 and involved in lung homing of E6/E7-expressing tumor cells were investigated. The contribution of the Rho/ROCK pathway was suggested by the inhibitory effect triggered by Cidofovir and further confirmed using Y-27632 (a small molecule ROCK inhibitor). These data suggest a novel and highly translatable therapeutic approach to cervix cancer, by inhibition of adhesion and invasion of circulating HPV-positive tumor cells, using Cidofovir and/or ROCK inhibition