Continuing Attacks on Nonprofit Speech: Death by a Thousand Cuts II

OMB Watch has published Continuing Attacks on Nonprofit Advocacy: Death by a Thousand Cuts II, which documents a pattern of attempts to limit the policy voice of nonprofits by the Bush administration and its conservative allies. The federal government has used audit powers, funding cuts and other tactics to take action against nonprofits that exercise their right to advocate on issues. See the Executive Summary and download the full report (in pdf format)

The Ursinus Weekly, March 19, 1951

Greek letter groups take in Spring rushees • Artist\u27s Life by Ruth Feidler wins Pageant contest • Students contribute record $175 to drive • Students to take part in Model United Nations talk • Debaters to attend parley • 3 seniors named into honorary dramatic group • Plays feature intense drama • Student vocalists to appear in HMS Pinafore • Board names Mary Yost to editorship of Weekly • Spring play cast headed by Henry, MacMullen, Grove • Lantern out Wednesday • YM-YW committee plans nomination • Seventh Heaven to be theme of Junior Prom April 20 • Letters to the editor • Robert Thompson\u27s death was \u2710 campus tragedy • Track squad loses three star runners • Girls, boys to play ball; WAA to reap benefits • Miller selected to coach \u2751 Ursinus tennis squad • Students feel press of daily problems; Studies, food and money predominate • South Pacific remains work of art worth waiting for • Swimming team defeats Pennsylvania by capturing four first place honors • Figures released in district scoring; Swett places 18th • Temple hands girls first court defeat • Weekly sports quiz • Badminton team downs Pennsylvania squad, 3-2 • Vadner\u27s last minute field goal defeats Rosemont; Belles trounce Albright 51-19 • Forum speaker opposes rearming West Germany • WSGA discusses Community Chest, changes in elections • Dart contest planned • Opportunities in ROC • Food council lists guests\u27 meal prices • Psychiatrist to talk • Soph dance a hit • Helfferich to read • To show movies • Meistersingers give Palm Sunday concert • Chess Club wins • Students asked to give blood again; 200 pints needed • Mrs. Alfred Creager speaks at meeting of Chi Alpha Societyhttps://digitalcommons.ursinus.edu/weekly/1563/thumbnail.jp

Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome

The oculocerebrorenal syndrome of Lowe (OCRL; MIM #309000) is an X-linked human disorder characterized by congenital cataracts, mental retardation, and renal proximal tubular dysfunction caused by loss-of-function mutations in the OCRL gene that encodes Ocrl, a type II phosphatidylinositol bisphosphate (PtdIns4,5P2) 5-phosphatase. In contrast, mice with complete loss-of-function of the highly homologous ortholog Ocrl have no detectable renal, ophthalmological, or central nervous system abnormalities. We inferred that the disparate phenotype between Ocrl-deficient humans and mice was likely due to differences in how the two species compensate for loss of the Ocrl enzyme. We therefore turned our attention to Inpp5b, another type II PtdIns4,5P2 5-phosphatase encoded by Inpp5b in mice and INPP5B in humans, as potential compensating genes in the two species, because Inpp5b/INPP5B are the most highly conserved paralogs to Ocrl/OCRL in the respective genomes of both species and Inpp5b demonstrates functional overlap with Ocrl in mice in vivo. We used in silico sequence analysis, reverse-transcription PCR, quantitative PCR, and transient transfection assays of promoter function to define splice-site usage and the function of an internal promoter in mouse Inpp5b versus human INPP5B. We found mouse Inpp5b and human INPP5B differ in their transcription, splicing, and primary amino acid sequence. These observations form the foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl function and, by providing insight into the cellular roles of Ocrl and Inpp5b, aid in the development of a model system in which to study Lowe syndrome

The Ursinus Weekly, October 30, 1950

Four fraternities institute rushing in first semester • Dr. Miller speaks to IRC on value of United Nations • Forum to present English economist next Monday night • Junior class to sponsor Shipwreck Ball Friday • Omwake goes to Virginia • Sportsmen meet in gym • Masquerade postponed • MSGA takes steps toward setting up dorm government • Discussion of domestic and political problems features rally • Sororities on campus open annual week of rushing • IRC to sponsor John C. Kunkel at open forum • Red Cross unit sets up five groups on campus • Philadelphia doctor presents program at pre-med meeting • Yost to present reading • Bud Buchanan is official doughnut-maker • Antiques are prime hobby of Mrs. Donald Helfferich • Outstanding Ursinus graduate honored at recent Pennsylvania week luncheon • Committee heads further work for Dusty Halo • Canterbury Club sponsors series of talks on marriage • Chesterfield announces contest for campus photographers • Y to present series of speakers in lieu of Emphasis Week • Alumnus awarded doctorate by Drew on Founders Day • MSGA fills two posts; Kern, Rearick selected • French Club to present program November 1 at Studio Cottage • Hockey team falls to Bryn Mawr, 2-1; JV Belles tie, 2-2 • F & M to provide strong opposition for Bruin eleven • Bears beat Seahawks 25-6 to continue surge: Fischer paces Grizzlies with long scoring runs • Soccer squad drops pair of decisions to Lincoln and Swarthmore booters • Belles get 5-0 win at William and Mary • Albright registers big 17-40 victory over Bear Harriers • Philadelphia Orchestra to give concerts at Academy of Music • Bachman talks at vespershttps://digitalcommons.ursinus.edu/weekly/1550/thumbnail.jp

The Ursinus Weekly, February 12, 1951

New high set by B-list group as 106 qualify • Y schedules chats, conducts retreat • Paynter-Keller production scores hit in Curtain Club group presentation • Play contest in progress; May Day heads named • Alumna to speak at girls\u27 Color Day program Thursday • Eight enter Ursinus for Spring term • Forum to feature Indian editor at next session • Speak Easy title of Ruby show • TV auditions slated • 3 graduate school test dates released • Ursinus to enter competition in intercollegiate bridge • Dr. Miller to give IRC summary of Department of State conferences attended in recent weeks • Washington trip planned by PAC • Meistersingers give concert • Editorial: Attend forums? • Senior class discusses Ruby and after-game record dance • Red Cross to organize • Juniors discuss bands • French Club to present dance Wednesday night in music studio • Thespians to discuss play • Dictionary of Folklore and Legend includes work of Dr. Phillips on Pennsylvania Dutch • Behind-scenes Dean handles transcripts, records dating from 1873, in routine work • Men reveal resignation toward draft situation • Alumnae back and Duryea\u27s got \u27em; Grads return in role of preceptresses • Coach Seeders drives Bruins toward coveted Middle Atlantic championship • Grizzlies win and lose in non-league contests • Bears edge Blue Hens for loop lead, 62-60 • Mermaids triumph over Drexel, 35-22 • Belles bag first over Bryn Mawr • Brodbeck I & II, Stine lead • Dr. Baker chooses poetry of A. E. Housman for readinghttps://digitalcommons.ursinus.edu/weekly/1558/thumbnail.jp

The Ursinus Weekly, February 12, 1951

New high set by B-list group as 106 qualify • Y schedules chats, conducts retreat • Paynter-Keller production scores hit in Curtain Club group presentation • Play contest in progress; May Day heads named • Alumna to speak at girls\u27 Color Day program Thursday • Eight enter Ursinus for Spring term • Forum to feature Indian editor at next session • Speak Easy title of Ruby show • TV auditions slated • 3 graduate school test dates released • Ursinus to enter competition in intercollegiate bridge • Dr. Miller to give IRC summary of Department of State conferences attended in recent weeks • Washington trip planned by PAC • Meistersingers give concert • Editorial: Attend forums? • Senior class discusses Ruby and after-game record dance • Red Cross to organize • Juniors discuss bands • French Club to present dance Wednesday night in music studio • Thespians to discuss play • Dictionary of Folklore and Legend includes work of Dr. Phillips on Pennsylvania Dutch • Behind-scenes Dean handles transcripts, records dating from 1873, in routine work • Men reveal resignation toward draft situation • Alumnae back and Duryea\u27s got \u27em; Grads return in role of preceptresses • Coach Seeders drives Bruins toward coveted Middle Atlantic championship • Grizzlies win and lose in non-league contests • Bears edge Blue Hens for loop lead, 62-60 • Mermaids triumph over Drexel, 35-22 • Belles bag first over Bryn Mawr • Brodbeck I & II, Stine lead • Dr. Baker chooses poetry of A. E. Housman for readinghttps://digitalcommons.ursinus.edu/weekly/1558/thumbnail.jp

The Ursinus Weekly, March 5, 1951

Helfferich retains MAC title; Voted outstanding • Music Club lists HMS Pinafore as Spring production • Community Chest receives support • MSGA holds discussion on guests\u27 meal prices • Brownback receives material for May 4, 5 grad record exam • Dr. McClure to view Ursinus problems at YM-YWCA meeting • Group presentation of Condemned scores hit • DuPont lecturer shows new super light plastic • Larry Livingston, DuPont manager, to speak here • Dr. Yost to read poetry of Edna St. Vincent Millay • Administration receives additional data on draft • Seniors\u27 original Speak Easy ready for production • Lantern staff prepares issue; Meeting called • Notecrackers lose coin-tossing finals • Charles Lachman donates rug for Library faculty room • Red Cross drive begins • Rushing starts Monday • Editorial: Participation makes spirit; Support Red Cross; Lenten thoughts • L-shaped office is language office, where all is congeniality, cooperation, cordiality • Star gazers view sky, map moon through telescope atop Pfahler Hall • Staff grinds out The Weekly midst daily confusion • Swarthmore knocks Ursinus quintet from league contention in 78-56 win • Jerry Seeders awaits word on call to Army; Was captain in last war • Quintet winds up season in 95-62 loss to Blue Hens • Bear matmen rally, tie Drexel 14-14 • Belles defeat Penn to stay unbeaten • Mermaids capture fourth place in district intercollegiate meet • Club holds supperhttps://digitalcommons.ursinus.edu/weekly/1561/thumbnail.jp