1,330 research outputs found
FLASC: A Flare-Sensitive Clustering Algorithm: Extending HDBSCAN* for Detecting Branches in Clusters
We present FLASC, an algorithm for flare-sensitive clustering. Our algorithm
builds upon HDBSCAN* -- which provides high-quality density-based clustering
performance -- through a post-processing step that differentiates branches
within the detected clusters' manifold, adding a type of pattern that can be
discovered. Two variants of the algorithm are presented, which trade
computational cost for noise robustness. We show that both variants scale
similarly to HDBSCAN* in terms of computational cost and provide stable outputs
using synthetic data sets, resulting in an efficient flare-sensitive clustering
algorithm. In addition, we demonstrate the algorithm's benefit in data
exploration over HDBSCAN* clustering on two real-world data sets.Comment: 20 pages, 11 figures, submitted to ACM TKD
Modeling and predicting the shape of the far-infrared to submillimeter emission in ultra-compact HII regions and cold clumps
Dust properties are very likely affected by the environment in which dust
grains evolve. For instance, some analyses of cold clumps (7 K- 17 K) indicate
that the aggregation process is favored in dense environments. However,
studying warm (30 K-40 K) dust emission at long wavelength (300
m) has been limited because it is difficult to combine far
infared-to-millimeter (FIR-to-mm) spectral coverage and high angular resolution
for observations of warm dust grains. Using Herschel data from 70 to 500
m, which are part of the Herschel infrared Galactic (Hi-GAL) survey
combined with 1.1 mm data from the Bolocam Galactic Plane Survey (BGPS), we
compared emission in two types of environments: ultra-compact HII (UCHII)
regions, and cold molecular clumps (denoted as cold clumps). With this
comparison we tested dust emission models in the FIR-to-mm domain that
reproduce emission in the diffuse medium, in these two environments (UCHII
regions and cold clumps). We also investigated their ability to predict the
dust emission in our Galaxy. We determined the emission spectra in twelve UCHII
regions and twelve cold clumps, and derived the dust temperature (T) using the
recent two-level system (TLS) model with three sets of parameters and the
so-called T- (temperature-dust emissvity index) phenomenological models,
with set to 1.5, 2 and 2.5. We tested the applicability of the TLS
model in warm regions for the first time. This analysis indicates distinct
trends in the dust emission between cold and warm environments that are visible
through changes in the dust emissivity index. However, with the use of standard
parameters, the TLS model is able to reproduce the spectral behavior observed
in cold and warm regions, from the change of the dust temperature alone,
whereas a T- model requires to be known.Comment: Accepted for publication in A&A. 19 pages, 8 figures, 7 table
Hierarchical progressive surveys. Multi-resolution HEALPix data structures for astronomical images, catalogues, and 3-dimensional data cubes
Scientific exploitation of the ever increasing volumes of astronomical data
requires efficient and practical methods for data access, visualisation, and
analysis. Hierarchical sky tessellation techniques enable a multi-resolution
approach to organising data on angular scales from the full sky down to the
individual image pixels. Aims. We aim to show that the Hierarchical progressive
survey (HiPS) scheme for describing astronomical images, source catalogues, and
three-dimensional data cubes is a practical solution to managing large volumes
of heterogeneous data and that it enables a new level of scientific
interoperability across large collections of data of these different data
types. Methods. HiPS uses the HEALPix tessellation of the sphere to define a
hierarchical tile and pixel structure to describe and organise astronomical
data. HiPS is designed to conserve the scientific properties of the data
alongside both visualisation considerations and emphasis on the ease of
implementation. We describe the development of HiPS to manage a large number of
diverse image surveys, as well as the extension of hierarchical image systems
to cube and catalogue data. We demonstrate the interoperability of HiPS and
Multi-Order Coverage (MOC) maps and highlight the HiPS mechanism to provide
links to the original data. Results. Hierarchical progressive surveys have been
generated by various data centres and groups for ~200 data collections
including many wide area sky surveys, and archives of pointed observations.
These can be accessed and visualised in Aladin, Aladin Lite, and other
applications. HiPS provides a basis for further innovations in the use of
hierarchical data structures to facilitate the description and statistical
analysis of large astronomical data sets.Comment: 21 pages, 6 figures. Accepted for publication in Astronomy &
Astrophysic
Gaps in the cloud cover? Comparing extinction measures in spiral disks
Dust in galaxies can be mapped by either the FIR/sub-mm emission, the optical
or infrared reddening of starlight, or the extinction of a known background
source. We compare two dust extinction measurements for a set of fifteen
sections in thirteen nearby galaxies, to determine the scale of the dusty ISM
responsible for disk opacity: one using stellar reddening and the other a known
background source. In our earlier papers, we presented extinction measurements
of 29 galaxies, based on calibrated counts of distant background objects
identified though foreground disks in HST/WFPC2 images. For the 13 galaxies
that overlap with the Spitzer Infrared Nearby Galaxies Survey (SINGS), we now
compare these results with those obtained from an I-L color map. Our goal is to
determine whether or not a detected distant galaxy indicates a gap in the dusty
ISM, and hence to better understand the nature and geometry of the disk
extinction.
We find that distant galaxies are predominantly in low-extinction sections
marked by the color maps, indicating that their number depends both on the
cloud cover of {\it Spitzer}-resolved dust structures --mostly the spiral
arms--and a diffuse, unresolved underlying disk. We note that our infrared
color map (E[I-L]) underestimates the overall dust presence in these disks
severely, because it implicitly assumes the presence of a dust screen in front
of the stellar distribution.Comment: 22 pages, 2 figures, 3 tables, accepted for publication in A
The dust properties and physical conditions of the interstellar medium in the LMC massive star forming complex N11
We combine Spitzer and Herschel data of the star-forming region N11 in the
Large Magellanic Cloud to produce detailed maps of the dust properties in the
complex and study their variations with the ISM conditions. We also compare
APEX/LABOCA 870um observations with our model predictions in order to decompose
the 870um emission into dust and non-dust (free-free emission and CO(3-2) line)
contributions. We find that in N11, the 870um can be fully accounted for by
these 3 components. The dust surface density map of N11 is combined with HI and
CO observations to study local variations in the gas-to-dust mass ratios. Our
analysis leads to values lower than those expected from the LMC low-metallicity
as well as to a decrease of the gas-to-dust mass ratio with the dust surface
density. We explore potential hypotheses that could explain the low observed
gas-to-dust mass ratios (variations in the XCO factor, presence of CO-dark gas
or of optically thick HI or variations in the dust abundance in the dense
regions). We finally decompose the local SEDs using a Principal Component
Analysis (i.e. with no a priori assumption on the dust composition in the
complex). Our results lead to a promising decomposition of the local SEDs in
various dust components (hot, warm, cold) coherent with that expected for the
region. Further analysis on a larger sample of galaxies will follow in order to
understand how unique this decomposition is or how it evolves from one
environment to another.Comment: 24 pages, 16 figures, accepted for publication in MNRA
The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit
Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals. The impact of high-resolution activity data collected from mobile phones is only beginning to be explored. Here we present data from mPower, a clinical observational study about Parkinson disease conducted purely through an iPhone app interface. The study interrogated aspects of this movement disorder through surveys and frequent sensor-based recordings from participants with and without Parkinson disease. Benefitting from large enrollment and repeated measurements on many individuals, these data may help establish baseline variability of real-world activity measurement collected via mobile phones, and ultimately may lead to quantification of the ebbs-and-flows of Parkinson symptoms. App source code for these data collection modules are available through an open source license for use in studies of other conditions. We hope that releasing data contributed by engaged research participants will seed a new community of analysts working collaboratively on understanding mobile health data to advance human health
Dust emission at 8-mic and 24-mic as Diagnostics of HII Region Radiative Transfer
We use the Spitzer SAGE survey of the Magellanic Clouds to evaluate the
relationship between the 8-mic PAH emission, 24-mic hot dust emission, and HII
region radiative transfer. We confirm that in the higher-metallicity Large
Magellanic Cloud, PAH destruction is sensitive to optically thin conditions in
the nebular Lyman continuum: objects identified as optically thin candidates
based on nebular ionization structure show 6 times lower median 8-mic surface
brightness (0.18 mJy arcsec^-2) than their optically thick counterparts (1.2
mJy arcsec^-2). The 24-mic surface brightness also shows a factor of 3 offset
between the two classes of objects (0.13 vs 0.44 mJy arcsec^-2, respectively),
which is driven by the association between the very small dust grains and
higher density gas found at higher nebular optical depths. In contrast, PAH and
dust formation in the low-metallicity Small Magellanic Cloud is strongly
inhibited such that we find no variation in either 8-mic or 24-mic emission
between our optically thick and thin samples. This is attributable to extremely
low PAH and dust production together with high, corrosive UV photon fluxes in
this low-metallicity environment. The dust mass surface densities and
gas-to-dust ratios determined from dust maps using Herschel HERITAGE survey
data support this interpretation.Comment: Accepted to ApJ, May 15, 2017. 10 pages, 9 figure
Evaluating 5-nitrofurans as trypanocidal agents
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction catalysed by a type I nitroreductase (NTR), an enzyme found predominantly in prokaryotes, leading to the formation of a cytotoxic unsaturated open chain nitrile metabolite. Here, we evaluate the trypanocidal activity of a library of other 5-nitrofurans against bloodstream form T. brucei as a preliminary step in the identification of additional nitroaromatic compounds that could potentially partner eflornithine. Biochemical screening against purified enzyme revealed that all 5-nitrofurans were effective substrates for TbNTR with the preferred compounds having apparent kcat/KM values approximately 50-fold greater than nifurtimox. For several compounds, in vitro reduction by this nitroreductase yielded products characterized by mass spectroscopy as either unsaturated or saturated open chain nitriles. When tested against bloodstream form T. brucei, many of the derivatives displayed significant growth inhibitory properties with the most potent compounds generating IC50 values around 200 nM. The anti-parasitic activity of the most potent agents was demonstrated to be NTR dependent as parasites having reduced levels of the enzyme displayed resistance to the compounds while parasites over expressing TbNTR showed hypersensitivity. We conclude that other members of the 5-nitrofurans class of nitroheterocycles have potential to treat human African trypanosomiasis perhaps as an alternative partner prodrug to nifurtimox in the next generation of eflornithine-based combinational therapies
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