Transcriptional regulation of DC fate specification

Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future

Fuzzy audio similarity measures based on spectrum histograms and fluctuation patterns

Spectrum histograms and fluctuation patterns are representations of audio fragments. By comparing these representations, we can determine the similarity between the corresponding fragments. Traditionally, this is done using the Euclidian distance. We propose fuzzy similarity measures as an alternative. First we introduce some well-known fuzzy similarity measures, together with certain properties that can be desirable or useful in practice. In particular we present several forms of restrictability, which allow to reduce the computation time in practical applications. Next, we show that fuzzy similarity measures can be used to compare spectrum histograms and fluctuation patterns. Finally, we describe some experimental observations for this fuzzy approach of constructing audio similarity measures

HEGEL EN AMÉRICA

Este artículo reinterpreta a Hegel y su visión de la historia desde el sur global. El escrito sitúa las Lecciones de Filosofía de la Historia de Hegel en el contexto de la expansión colonial europea a las Américas en 1492 y el surgimiento del imperio estadounidense desde 1898 hasta hoy. El artículo desarrolla una crítica a la visión hegeliana del futuro y provincializa el hegelianismo sacándolo de la narrativa de la historia universal y situándolo en la historia de los imperialismos occidentales El artículo hace una lectura de Hegel contra Hegel mismo como pensador de la no-identidad, de la alteridad. La singularidad como categoría que niega tanto lo general como lo particular es defendida frente a cierta lectura sobre Hegel que piensa el concepto como la subsunción de lo particular en lo general. El artículo hace una lectura de la novela de José Revueltas Los Errores como antecedente de las preguntas que Alain Badiou se hizo 40 años después. Finaliza defendiendo un comunismo de izquierda

From Marx to Heidegger: Oscar del Barco and the crisis of Marxism

This article traces the path from Marx to Heidegger along which the Argentine philosopher Oscar del Barco responded to the crisis of Marxism. Interrogating Heidegger’s own suggestion of a ‘fruitful dialogue’ with Marx’s thinking of history and alienation, Del Barco gradually moved to a critique of Marxism as being part and parcel of the twice millenarian tradition of Western metaphysics. If, in an earlier collection such as El otro Marx, he still believed in the possibility of retrieving the ‘other side’ of capitalist reason in the margins of Marx’s texts, starting in the collection El abandono de las palabras this hope gives way to a mystical or messianic expectation to welcome the sheer ‘there is’ of being through an attitude of non-doing that would be neither nihilist nor conformist. In this sense Del Barco’s itinerary can be considered paradigmatic of the way in which a whole school of radical theory and philosophy responded to the crisis of Marxism as part of a much vaster, epochal or civilisational crisis of reason and technology in the West

The position of diagnostic laparoscopy in current fertility practice

In everyday clinical practice, it is not always clear if and when exactly in the fertility work-up a diagnostic laparoscopy should be offered. The aim of this review is to analyse the available evidence with respect to alternative diagnostic methods for detecting tuboperitoneal infertility and with respect to the position of diagnostic laparoscopy in women with infertility. A literature search of the National Library of Medicine and the National Institutes of Health (PubMed) was performed using the key words 'diagnostic laparoscopy and infertility'. The study methodology was carefully considered in an effort to present conclusions preferably based on randomized controlled trials (RCTs). The routine use of diagnostic laparoscopy for the evaluation of all cases of female infertility is currently under debate. According to data published in retrospective non-controlled studies, diagnostic laparoscopy after several failed cycles of ovulation induction enables the detection of a significant proportion of pelvic pathology amenable to treatment. A Cochrane review has shown that laparoscopic ovarian diathermy in clomiphene-resistant polycystic ovarian syndrome is at least as effective as gonadotrophin treatment, and results in a lower multiple pregnancy rate. The role of laparoscopy before the start of treatment with intrauterine insemination is controversial, according to one RCT. In women with bilateral ultrasonically visible hydrosalpinges, two RCTs have demonstrated increased implantation and pregnancy rates in IVF cycles after salpingectomy. Although RCTs which have studied the benefit of laparoscopic surgery in moderate or severe endometriosis are still lacking, its value has generally been accepted. In conclusion, some specific clinical settings, solid evidence is available to recommend the use of diagnostic laparoscopy in current fertility practice. There is however a need for more RCTs to answer remaining questions regarding its value in the diagnosis and treatment of some patients with infertility

Outpatient treatment for uterine polyps : a long overdue break with traditional practice, backed up by solid evidence

Editorialstatus: publishe

Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities

Background : Observational studies suggest higher pregnancy rates after the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions, which are detectable in 10% to 15% of women seeking treatment for subfertility. Objectives : To assess the effects of the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions suspected on ultrasound, hysterosalpingography, diagnostic hysteroscopy or any combination of thesemethods inwomenwith otherwise unexplained subfertility or prior to intrauterine insemination (IUI), in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). Search methods : We searched theCochraneMenstrualDisorders and Subfertility SpecialisedRegister (8 September 2014), theCochrane Central Register of Controlled Trials (The Cochrane Library 2014, Issue 9), MEDLINE (1950 to 12 October 2014), EMBASE (inception to 12 October 2014), CINAHL (inception to 11 October 2014) and other electronic sources of trials including trial registers, sources of unpublished literature and reference lists. We handsearched the American Society for Reproductive Medicine (ASRM) conference abstracts and proceedings (from January 2013 to October 2014) and we contacted experts in the field. Selection criteria : Randomised comparisons between operative hysteroscopy versus control in women with otherwise unexplained subfertility or undergoing IUI, IVF or ICSI and suspected major uterine cavity abnormalities diagnosed by ultrasonography, saline infusion/ gel instillation sonography, hysterosalpingography, diagnostic hysteroscopy or any combination of these methods. Primary outcomes were live birth and hysteroscopy complications. Secondary outcomes were pregnancy and miscarriage. Data collection and analysis : Two review authors independently assessed studies for inclusion and risk of bias, and extracted data. We contacted study authors for additional information. Main results : We retrieved 12 randomised trials possibly addressing the research questions. Only two studies (309 women) met the inclusion criteria. Neither reported the primary outcomes of live birth or procedure related complications. In women with otherwise unexplained subfertility and submucous fibroids there was no conclusive evidence of a difference between the intervention group treated with hysteroscopic myomectomy and the control group having regular fertility-oriented intercourse during 12 months for the outcome of clinical pregnancy. A large clinical benefit with hysteroscopic myomectomy cannot be excluded: if 21% of women with fibroids achieve a clinical pregnancy having timed intercourse only, the evidence suggests that 39% of women (95% CI 21% to 58%) will achieve a successful outcome following the hysteroscopic removal of the fibroids (odds ratio (OR) 2.44, 95% confidence interval (CI) 0.97 to 6.17, P = 0.06, 94 women, very low quality evidence). There is no evidence of a difference between the comparison groups for the outcome of miscarriage (OR 0.58, 95% CI 0.12 to 2.85, P = 0.50, 30 clinical pregnancies in 94 women, very low quality evidence). The hysteroscopic removal of polyps prior to IUI can increase the chance of a clinical pregnancy compared to simple diagnostic hysteroscopy and polyp biopsy: if 28% of women achieve a clinical pregnancy with a simple diagnostic hysteroscopy, the evidence suggests that 63% of women (95% CI 50% to 76%) will achieve a clinical pregnancy after the hysteroscopic removal of the endometrial polyps (OR 4.41, 95% CI 2.45 to 7.96, P < 0.00001, 204 women, moderate quality evidence). Authors' conclusions : A large benefit with the hysteroscopic removal of submucous fibroids for improving the chance of clinical pregnancy in women with otherwise unexplained subfertility cannot be excluded. The hysteroscopic removal of endometrial polyps suspected on ultrasound in women prior to IUI may increase the clinical pregnancy rate. More randomised studies are needed to substantiate the effectiveness of the hysteroscopic removal of suspected endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions in women with unexplained subfertility or prior to IUI, IVF or ICSI