7,815 research outputs found
The Detection of a 3.5-h Period in the Classical Nova Velorum 1999 (V382 Vel) and the Long Term Behavior of the Nova Light Curve
We present CCD photometry, light curve and time series analysis of the
classical nova V382 Vel (N Vel 1999). The source was observed for 2 nights in
2000, 21 nights in 2001 and 7 nights in 2002 using clear filters. We report the
detection of a distinct period in the light curve of the nova P=0.146126(18) d
(3.5 h). The period is evident in all data sets, and we interpret it as the
binary period of the system. We also measured an increase in the amplitude
modulation of the optical light (in magnitude) by more than 55% from 2000 to
2001 and about 64% from 2001 to 2002. The pulse profiles in 2001 show
deviations from a pure sinusoidal shape which progressively become more
sinusoidal by 2002. The main cause of the variations in 2001 and 2002 can be
explained with the occultation of the accretion disk by the secondary star. We
interpret the observed deviations from a pure sinusoidal shape as additional
flux resulting from the aspect variations of the irradiated face of the
secondary star.Comment: 16 pages and 4 figures, accepted as it stands to be published in the
Astronomical Journal (AJ
Wess-Zumino-Witten model off criticality
We study the renormalization group flow properties of the Wess-Zumino-Witten
model in the region of couplings between and , by
evaluating the two-loop Zamolodchikov's -function. We also discuss the
region of negative couplings.Comment: 8 page
The effect of three years of TNF alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study
INTRODUCTION: The aim of this study was to investigate the effect of three years of tumor necrosis factor-alpha (TNF-alpha) blocking therapy on bone turnover as well as to analyze the predictive value of early changes in bone turnover markers (BTM) for treatment discontinuation in patients with ankylosing spondylitis (AS). METHODS: This is a prospective cohort study of 111 consecutive AS outpatients who started TNF-alpha blocking therapy. Clinical assessments and BTM were assessed at baseline, three and six months, as well as at one, two, and three years. Z-scores of BTM were calculated to correct for age and gender. Bone mineral density (BMD) was assessed yearly. RESULTS: After three years, 72 patients (65%) were still using their first TNF-alpha blocking agent. In these patients, TNF-alpha blocking therapy resulted in significantly increased bone-specific alkaline phosphatase, a marker of bone formation; decreased serum collagen-telopeptide (sCTX), a marker of bone resorption; and increased lumbar spine and hip BMD compared to baseline. Baseline to three months decrease in sCTX Z-score (HR: 0.394, 95% CI: 0.263 to 0.591), AS disease activity score (ASDAS; HR: 0.488, 95% CI: 0.317 to 0.752), and physician's global disease activity (HR: 0.739, 95% CI: 0.600 to 0.909) were independent inversely related predictors of time to treatment discontinuation because of inefficacy or intolerance. Early decrease in sCTX Z-score correlated significantly with good long-term response regarding disease activity, physical function and quality of life. CONCLUSIONS: Three years of TNF-alpha blocking therapy results in a bone turnover balance that favors bone formation, especially mineralization, in combination with continuous improvement of lumbar spine BMD. Early change in sCTX can serve as an objective measure in the evaluation of TNF-alpha blocking therapy in AS, in addition to the currently used more subjective measures
Broilers with Taste - Sustainable chicken takes flight
Engelse versie van de brochure 'Pluimvee met smaak : duurzame kip krijgt vleugels', die laat zien waar kansen liggen voor de Nederlandse pluimveesector om te verduurzamen. Twee uiteenlopende concepten, de Som der Delen en de Windstreek, geven ieder op eigen wijze invulling aan duurzaamheid op het primaire bedrijf. Ze bevatten belangrijke elementen voor verduurzaming, die als geheel of in onderdelen, nu of later, in de praktijk gebracht kunnen worden. Duurzaamheid kent immers niet één, maar vele vormen, afhankelijk van de ondernemers, de markt en de omgeving
On the identity of broad-shelled mussels (Mollusca, Bivalvia, Mytilus) from the Dutch delta region
Late Quaternary (Eemian) deposits of the Netherlands contain
shells that resemble those of living Mytilus galloprovincialis.
Similar broad-shelled mytilids also occur in estuaries of the
southwestern Netherlands together with slender individuals
typical of M. edulis. We sampled living mussels along a depth
gradient in the Oosterschelde to a) investigate whether a relation
exists between shell shape and depth, b) test if the broadshelled
specimens might represent M. galloprovincialis (or a
hybrid with M. edulis) and c) assess by inference if the Quaternary
specimens might be attributed to M. galloprovincialis as
well. In order to do so, we compared genetic (length polymorphism
of Me 15/16, COIII sequences and AFLPs) and shellmorphological
characteristics (juvenile L/W ratios and socalled
Verduin parameters) of the same specimens. The obtained
dataset indicates that all studied mussels from the Oosterschelde
should be attributed to M. edulis, including those with
broad shell outlines. No correlation of shell-morphology and
depth-distribution was found. The worn and generally damaged
state of the Eemian specimens precluded measurement of the
Verduin parameters, while juvenile L/W ratios turned out not to
be diagnostic. Therefore the shell characters examined in this
study are insufficient to demonstrate the possible presence of
M. galloprovincialis shells in Quaternary deposits of the Netherlands.
Decuplet baryon magnetic moments in a QCD-based quark model beyond quenched approximation
We study the decuplet baryon magnetic moments in a QCD-based quark model
beyond quenched approximation. Our approach for unquenching the theory is based
on the heavy baryon perturbation theory in which the axial couplings for baryon
- meson and the meson-meson-photon couplings from the chiral perturbation
theory are used together with the QM moment couplings. It also involves the
introduction of a form factor characterizing the structure of baryons
considered as composite particles. Using the parameters obtained from fitting
the octet baryon magnetic moments, we predict the decuplet baryon magnetic
moments. The magnetic moment is found to be in good agreement with
experiment: is predicted to be compared to the
experimental result of (2.02 0.05) .Comment: 19 pages, 2 figure
Ferromagnetism below 10 K in Mn doped BiTe
Ferromagnetism is observed below 10 K in [Bi0.75Te0.125Mn0.125]Te. This
material has the BiTe structure, which is made from the stacking of two
Te-Bi-Te-Bi-Te blocks and one Bi-Bi block per unit cell. Crystal structure
analysis shows that Mn is localized in the Bi2 blocks, and is accompanied by an
equal amount of TeBi anti-site occupancy in the Bi2Te3 blocks. These TeBi
anti-site defects greatly enhance the Mn solubility. This is demonstrated by
comparison of the [Bi1-xMnx]Te and [Bi1-2xTexMnx]Te series; in the former, the
solubility is limited to x = 0.067, while the latter has xmax = 0.125. The
magnetism in [Bi1-xMnx]Te changes little with x, while that for
[Bi1-2xTexMnx]Te shows a clear variation, leading to ferromagnetism for x >
0.067. Magnetic hysteresis and the anomalous Hall Effect are observed for the
ferromagnetic samples.Comment: Accepted for publication in Phys. Rev.
Feasibility of a dose-intensive CMF regimen with granulocyte colony-stimulating factor as adjuvant therapy in premenopausal patients with node-positive breast cancer
Our aim was to study the feasibility of an intensified intravenous CMF (cyclophosphamide, methotrexate and 5-fluorouracil) schedule with the aim to escalate dose intensity (DI). Twenty-three premenopausal breast cancer patients received 6 cycles of adjuvant CMF intravenously on days 1 and 8 every 3 weeks and granulocyte colony-stimulating factor days 9–18. Endpoints were DI and toxicity. Twenty-one out of 23 patients (91%) received the projected total dose and reached ≥ 85% of the projected DI. Compared to ‘classical’ CMF, all patients reached ≥ 111% DI. Nine patients received the planned schedule without delay. Thirteen patients (57%) were treated for infection and four patients (17%) were hospitalized for febrile neutropenia. Twelve patients received red blood cell transfusions (52%). Radiation therapy (n= 6) had no adverse impact on dose intensity or haematological toxicity. This dose-intensified CMF schedule was accompanied by enhanced haematological toxicity with clinical sequelae, namely fever, intravenous antibiotics and red blood cell transfusions, but allows a high dose intensity in a majority of patients. © 2000 Cancer Research Campaig
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