Resonant origin for density fluctuations deep within the Sun: helioseismology and magneto-gravity waves

We analyze helioseismic waves near the solar equator in the presence of magnetic fields deep within the solar radiative zone. We find that reasonable magnetic fields can significantly alter the shapes of the wave profiles for helioseismic g-modes. They can do so because the existence of density gradients allows g-modes to resonantly excite Alfven waves, causing mode energy to be funnelled along magnetic field lines, away from the solar equatorial plane. The resulting wave forms show comparatively sharp spikes in the density profile at radii where these resonances take place. We estimate how big these waves might be in the Sun, and perform a first search for observable consequences. We find the density excursions at the resonances to be too narrow to be ruled out by present-day analyses of p-wave helioseismic spectra, even if their amplitudes were to be larger than a few percent. (In contrast it has been shown in (Burgess et al. 2002) that such density excursions could affect solar neutrino fluxes in an important way.) Because solar p-waves are not strongly influenced by radiative-zone magnetic fields, standard analyses of helioseismic data should not be significantly altered. The influence of the magnetic field on the g-mode frequency spectrum could be used to probe sufficiently large radiative-zone magnetic fields should solar g-modes ever be definitively observed. Our results would have stronger implications if overstable solar g-modes should prove to have very large amplitudes, as has sometimes been argued.Comment: 18 pages, 6 figures; misprints correcte

Виховання студентської молоді у вищих медичних закладах України

Надзвичайно важливим завдання для вищого навчального закладу є створення належних умов для розвитку та задоволення культурних потреб студентiв, для їх самореалiзацiї, щоб випускники медичного вузу стали не просто знаючими спецiалiстами, а людьми творчими, духовно багатими iз демократичним баченням світу та етичним ставленням до нього, особливо до тих, кому невдовзi надаватимуть квалiфiковану медичну допомогу

Спосіб лектинохімічного дослідження

Реферат. Спосіб лектинохімічного дослідження, при якому поміщають досліджуваний препарат у 10 % розчин формаліну з подальшою декальцинацією та заключенням у парафін за загальноприйнятою методикою. Далі парафінові зрізи дофарбовують гематоксиліном Майєра на малій експозиції. Формула корисної моделі. Спосіб лектинохімічного дослідження, при якому поміщають досліджуваний препарат у 10 % розчин формаліну з подальшою декальцинацією та заключенням у парафін за загальноприйнятою методикою, який відрізняється тим, що далі парафінові зрізи 30 дофарбовують гематоксиліном Майєра на малій експозиції

The prognostic significance of tumour-stroma ratio in endometrial carcinoma.

Background: High tumour stromal content has been found to predict adverse clinical outcome in a range of epithelial tumours. The aim of this study was to assess the prognostic significance of tumour-stroma ratio (TSR) in endometrial adenocarcinomas and investigate its relationship with other clinicopathological parameters. Methods: Clinicopathological and 5-year follow-up data were obtained for a retrospective series of endometrial adenocarcinoma patients (n = 400). TSR was measured using a morphometric approach (point counting) on digitised histologic hysterectomy specimens. Inter-observer agreement was determined using Cohen’s Kappa statistic. TSR cut-offs were optimised using log-rank functions and prognostic significance of TSR on overall survival (OS) and disease-free survival (DFS) were determined using Cox Proportional Hazards regression analysis and Kaplan-Meier curves generated. Associations of TSR with other clinicopathological parameters were determined using non-parametric tests followed by Holm-Bonferroni correction for multiple comparisons. Results: TSR as a continuous variable associated with worse OS (P = 0.034) in univariable Cox-regression analysis. Using the optimal cut-off TSR value of 1.3, TSR-high (i.e. low stroma) was associated with worse OS (HR = 2.51; 95 % CI = 1.22–5.12; P = 0.021) and DFS (HR = 2.19; 95 % CI = 1.15–4.17; P = 0.017) in univariable analysis. However, TSR did not have independent prognostic significance in multivariable analysis, when adjusted for known prognostic variables. A highly significant association was found between TSR and tumour grade (P < 0.001) and lymphovascular space invasion (P < 0.001), both of which had independent prognostic significance in this study population. Conclusions: Low tumour stromal content associates with both poor outcome and with other adverse prognostic indicators in endometrial cancer, although it is not independently prognostic. These findings contrast with studies on many - although not all - cancers and suggest that the biology of tumour-stroma interactions may differ amongst cancer types

Морфофункциональная характеристика гемомикроциркуляторного русла красного костного мозга при моделировании острого асептического воспаления у крыс

In modern medicine, the structural components in various organs and tissues have been studied in great detail, but at the same time there are no works which would study hemomicrocirculation in the red bone marrow in the modeling of acute aseptic inflammation in rats, where reactive changes of morphological and functional character take place. The purpose of the work was to study the morphological changes of the components of the hemomicrocirculatory bed in the red bone mrrow of rats when modeling an acute aseptic inflammation. The work was performed on 50 mongrel white rats, divided into 2 groups: Group I–5 intact animals, Group II included 45 animals, which were simulated an acute aseptic peritonitis. In experimental groups of animal, an immediate, but reversible, increase in the penetration of venules and capillaries was observed, due to the active reduction of microfilaments in endothelial cells. In vascular lumens, during the experiment, a sludge syndrome was observed, which led to the difficulty of perfusion of blood corpuscles through the wall of the venule, which is a morphological confirmation of the inflammatory process.В сучаснiй медицинi досить докладно дослiдженi структурнi компоненти в рiзних органах i тканинах, i поряд з тим вiдсутні роботи в яких розглядаються дослідження гемомiкроциркуляцiї в червоному кiстковому мозку при моделюваннi гострого асептичного запалення у щурiв, де i вiдбуваються реактивнi змiни морфологiчного та функцiонального характеру. В експериментальній групі тварин спостерігалося негайне, але реверсивне, збільшення проникності венул і капілярів, завдяки активному скороченню мікрофіламентів в ендотеліальних клітинах. В просвітах судин, під час експерименту, спостерігався сладж синдром, який призвів до утруднення перфузії формених елементів крові через стінку венул, що є морфологічним підтвердженням запального процесу.В современной медицине достаточно подробно исследованы структурные компоненты в разных органах и тканях, вместе с тем отсутствует работы в которых рассматриваются исследования гемомикроциркуляции в красном костном мозге при моделировании острого асептического воспаления у крыс, где и происходят реактивные изменения морфологического и функционального характера В экспериментальной группе животных наблюдалось реверсивное увеличение проницаемости венул и капилляров, благодаря активному сокращению микрофиламентов в эндотелиальных клетках. В просветах сосудов, во время эксперимента наблюдался сладж-синдром, который привел к затруднению перфузии форменных элементов крови через стенку венул, что является морфологическим подтверждением воспалительного процесса

The structural organization of the red bone marrow of rats in normal condition and at the administration of cryopreserved placenta during acute aseptic inflammation

У дисертаційній роботі наведено теоретичне узагальнення та нове вирішення актуального наукового завдання, яке полягає у встановленні особливостей анатомічних, гістологічних, лектиногістохімічних, морфометричних змін структурних компонентів червоного кісткового мозку при введенні кріоконсервованої плаценти, при гострому експериментальному асептичному запаленні, при введенні кріоконсервованої плаценти на тлі гострого експериментального асептичного запалення. Комплексне морфологічне дослідження показало, що при гострому асептичному запаленні відбуваються значні зміни судинного русла червоного кісткового мозку та клітин еритробластного ряду. Встановлено, що застосування кріоконсервованої плаценти за умов експериментального асептичного запалення позитивно вливає на морфофункціональний стан компонентів червоного кісткового мозку та еритробластних острівців у динаміці дослідження; В диссертационной работе приведено теоретическое обобщение и новое решение актуальной научной задачи, которая заключается в установлении особенностей анатомических, гистологических, лектиногистохимических, морфометрических изменений структурных компонентов красного костного мозга при введении криоконсервированной плаценты, при остром асептическом воспалении, при введенни криоконсервованной плаценты на фоне острого асептического воспаления. Комплексное морфологическое исследование показало, что при остром ассептическом воспалении происходят существенные изменения сосудистого русла красного костного мозга и клеток эритробластного ряда. Установлено, что применение криоконсервированной плаценты при экспериментальном асептическом воспалении положительно влияет на морфофункциональное состояние компонентов красного костного мозга и эритробластных островков; The results of the dissertation research were aimed at detailed analysis and evaluation of structural components on the histological and ultramicroscopic levels that occurred during the administration of the cryopreserved placenta when modeling acute aseptic inflammation, and in the correction of acute aseptic inflammation by the introduction of cryopreserved placenta. It was established that the stroma of the red bone marrow of the intact group of animals, represented by bone beams and reticular tissue with a large number of blood vessels, and parenchyma, by erythroblastic islets, where differons of hematopoietic cells were revealed at different stages of differentiation. In the 1 experimental group of animals (when administering cryopreserved placenta), changes in the reactive units of the hemomicrocirculatory bed of the red bone marrow in rats were studied in the indicated terms of the experiment. When comparing the average diameters of the blood vessels in the hemomicrocirculatory bed with the corresponding indices of the intact group of animals, some dynamic changes were established which were manifested in the form of spasm, with subsequent expansion of the lumen of the vessels in different terms of the experiment. It was found that a single administration of a placental tissue affects the red bone marrow by dynamic changes, namely, by an enhanced erythropoiesis, resulting in an increase in the number of cells of the erythroblast islet at 2, 7 and 14 days of the study. The action of the cryopreserved placenta caused the active formation of basophilic, polychromatophilic, and orthochromic erythroblast in the specified period of the experiment. After analyzing the results of 3 experimental groups of animals (when modeling the acute aseptic inflammation), quantitative changes were observed that were phase-specific, namely, at 2, 7 and 14 days of the experiment, which is related to the activation of the erythropoiesis and the release of cells into peripheral blood. It was found that in the 3 group of animals, the inflammatory process extends not only to the parenchyma of the red bone marrow, but also to the elements of the hemomicrocirculatory bed. Thus, ultramicroscopic changes, which are manifested by decompensation processes in selective permeability and barrier function of the wall of the microvessels, were determined. On the part of the endothelial cells, their swelling was determined, which leads to the formation of folds, lacunas, and protrusions, and consequently the size of the vascular lumen significantly changed, and its shape changed from the right round or oval to irregular. Along with this, in the endothelial cells there was a loss of ordering and uniformity of microfilaments and myofilaments in myocytes, as well as the difference in endothelial contacts with the formation of cracks, through which the fluid from the blood plasma gets an excess into the parenchyma of a red bone marrow. As a result of these pathomorphological changes, on the ultramicroscopic level, it was noted that in the areas of folds and protrusions of the cytoplasm of the endothelial cell, a fusion of pinocytic vesicle with the formation of a vacuoles occurred, which leads to their further separation into the vascular lumen and subsequent necrotic and apoptotic changes. Changes in the diameter of the lumen of arterioles, capillaries and venules, in the 3 experimental group, were characterized by spasm with subsequent dilation of arterioles, accompanied by an enlargement of the lumen of capillaries and venules. It is established that the condition of arterioles, capillaries and venules is directly related to the period of acute experimental inflammation. In the 4 experimental group of animals (introduction of cryopreserved placenta during an acute aseptic inflammation), an increase in the number of all cells of the erythroblast islet was detected at 2, 7 and 14 days of observation. At the expense of biologically active substances containing placental tissue, the recovery of these cellular elements occurs at the late stages of the experiment, namely at 21 and 30 days of observation. The results of morphological and morphometric studies indicate that the dynamics of the inflammatory process at the administration of the placenta is significantly different from the course of the inflammatory process without correction. The action of placental tissue stimulates reparative processes, hormones and the biologically active substances cause dilatation and full blood vessels of the hemomicrocirculatory bedof the red bone marrow, thereby reducing the damaging factors caused by the introduction of λ-carrageenan, thereby confirming its antinflammatory effect. It has been experimentally proved that the restoration of the morphofunctional state of all parts of the hemomicrocirculatory bed of the red bone marrow occurs at the late stages of the experiment, and the recovery of the parameters to those in the intact group of animals is observed from 21 to 30 days of the study