Fractura de estrés del hueso grande del carpo: a propósito de un caso

Las fracturas traumáticas o por estrés del hueso grande del carpo (os capitate) son hallazgos realmente infrecuentes en la práctica clínica. Son una entidad que se debe sospechar ante un dolor insidioso y persistente en la palma de la mano en personas con una elevada demanda de esta extremidad o con traumatismos repetidos. En este artículo se presenta el caso de una jugadora de tenis de 16 años con dolor selectivo en la mano derecha de meses de evolución

Fractura d'estrès de l'os gran del carp: a propòsit d'un cas

Les fractures traumàtiques o per estrès de l'os gran del carp (os capitate) són troballes realment infreqüents en la pràctica clínica. Són una entitat que s'ha de sospitar davant un dolor insidiós i persistent al palmell de la mà en persones amb una elevada demanda d'aquesta extremitat o amb traumatismes repetits. En aquest article es presenta el cas d'una jugadora de tennis de 16 anys amb un dolor selectiu a nivell de la seva mà dreta de mesos d'evolució

Spleen-Dependent Immune Protection Elicited by CpG Adjuvanted Reticulocyte-Derived Exosomes from Malaria Infection Is Associated with Changes in T cell Subsets' Distribution

Added corrigendum published in 2017-01-17 https://doi.org/10.3389/fcell.2016.00153Reticulocyte-derived exosomes (rex) are 30-100 nm membrane vesicles of endocytic origin released during the maturation of reticulocytes to erythrocytes upon fusion of multivesicular bodies with the plasma membrane. Combination of CpG-ODN with rex obtained from BALB/c mice infected with the reticulocyte-prone non-lethal P. yoelii 17X malaria strain (rexPy), had been shown to induce survival and long lasting protection. Here, we show that splenectomized mice are not protected upon rexPy+CpG inmunizations and that protection is restored upon passive transfer of splenocytes obtained from animals immunized with rexPy+CpG. Notably, rexPy immunization of mice induced changes in PD1- memory T cells with effector phenotype. Proteomics analysis of rexPy confirmed their reticulocyte origin and demonstrated the presence of parasite antigens. Our studies thus prove, for what we believe is the first time, that rex from reticulocyte-prone malarial infections are associated with splenic long-lasting memory responses. To try extrapolating these data to human infections, in vitro experiments with spleen cells of human transplantation donors were performed. Plasma-derived exosomes from vivax malaria patients (exPv) were actively uptaken by human splenocytes and stimulated spleen cells leading to changes in T cell subsets