Innovations as a tool for providing cyber security and increasing the efficiency of banking system

Objective: to research innovative technologies as a means of protecting important information; to reveal the relationship between information security and improving the performance of banks.Methods: the problem of banks’ counteraction to cyberattacks was researched with systematic approach and a method of statistical analysis.Results: under the development of information and communication technologies, the problem of theft, modification, and forgery of information has acquired the greatest importance. Cyberattacks threaten the loss of personal data and can affect both the functioning of financial and commercial organizations, and the economy of the state as a whole. In this article, cyber threats are viewed as a priority problem of banks under widespread digitalization. The main trends in the field of cyber risks are identified; the dynamics of cyber attacks is studied. The activities carried out in Russia to prevent cybercrime are considered. The main reasons for cyber threats in the banking sector are systematized, including the human factor. Conclusions are made that in order to prevent cyberthreats it is necessary to introduce banking innovations based, among other things, on the positive foreign experience of applying the process-oriented approach, BigData technologies, blockchain, and biometric identification of customers.Scientific novelty: a set of measures was developed to introduce banking innovations and reduce cyber threats, including the development of cyber insurance.Practical significance: the proposed recommendations can be used in the practical activities of government agencies and banking professionals when making decisions in the field of cybersecurity

Antiproliferative activity of a new derivative from the class of N-glycoside of indolo [2,3-a] pyrrolo [3,4-c] carbazoles

The aim of the study was to evaluate an antiproliferative activity of a new, Russian derivative of N-glycoside substituted indolocarbazole 6-amino-12-(α-L-arabinopyranosyl)indolo [2,3-a] pyrrolo [3,4-c] carbazole-5,7-dione (LCS-1208) on models of transplantable tumors of mice and on human tumors in Balb/c nude mic

Инновационная работа с детьми-сиротами как фактор успешной адаптации

Найважливішою проблемою держави, суспільства, соціологічної науки залишається поширеність соціального сирітства і його наслідків. У статті розглядаються істотні проблеми, що перешкоджають інтеграції випускників сирітських установ у суспільство та основи інноваційної роботи з дітьми-сиротами як чинник їх успішної адаптації.By the major problem of the state, societies, sociological science there is prevalence of social orphanhood and his consequences. Important problems which hinder integration of graduating students of orphan establishments in society and bases of innovative work with children-orphans as a factor of their successful adaptation are examined in the article.Важнейшей проблемой государства, общества, социологической науки остается распространенность социального сиротства и его последствий. В статье рассматриваются важные проблемы, которые препятствуют интеграции выпускников сиротских учреждений в общество и основы инновационной работы с детьми-сиротами как фактор их успешной адаптации

PHARMACOGENETIC STUDY OF THE ACETYLATION PHENOTYPE IN A BULGARIAN POPULATION

N-acetyltransferase, an enzyme involved in the metabolic inactivation of drugs like isoniazide, some sulfonamides and others is well-known to he under polymorphic genetic control. The acetylation phenotype of the patients may serve as an important guide in foretelling the therapeutic efficacy or tolerahility of a particular drug. In the present study we investigated the distribution of the acetylaiion phenotypes in a group of 100 healthy volunteers of both sexes using sulfadimidine as a substrate. The distribution was found to follow a bimodal pattern, as aspected, with a slight predominance of the "slow" acetylators - in 58 % of the cases, a finding similar to literature data from neighbouring and other European countries. In the men's group the distribution was approximately the same as that in the whole group whilst in the women's one the "rapid" inactivators prevailed. This work represents the first modest attempt in Bulgaria for phenotyping the population according to the individual acetylaiion status

Spectroscopic determination of hole density in the ferromagnetic semiconductor Ga1−x_{1-x}Mnx_{x}As

The measurement of the hole density in the ferromagnetic semiconductor Ga$_{1-x}$Mn$_{x}$As is notoriously difficult using standard transport techniques due to the dominance of the anomalous Hall effect. Here, we report the first spectroscopic measurement of the hole density in four Ga$_{1-x}$Mn$_{x}$As samples ($x=0, 0.038, 0.061, 0.083$) at room temperature using Raman scattering intensity analysis of the coupled plasmon-LO-phonon mode and the unscreened LO phonon. The unscreened LO phonon frequency linearly decreases as the Mn concentration increases up to 8.3%. The hole density determined from the Raman scattering shows a monotonic increase with increasing $x$ for $x\leq0.083$, exhibiting a direct correlation to the observed $T_c$. The optical technique reported here provides an unambiguous means of determining the hole density in this important new class of ``spintronic'' semiconductor materials.Comment: two-column format 5 pages, 4 figures, to appear in Physical Review

Структура и биологическое действие аналогов и производных биогенных полиаминов

Objectives. Biogenic polyamines are widely present in nature. They are characteristic of both protozoan cells and multicellular organisms. These compounds have a wide range of biological functions and are necessary for normal growth and development of cells. Violation of polyamine homeostasis can cause significant abnormalities in cell functioning, provoking various pathological processes, including oncological and neuropsychiatric diseases. The impact on the “polyamine pathway” is an attractive basis for the creation of many pharmacological agents with a diverse spectrum of action. The purpose of this review is to summarize the results of the studies devoted to understanding the biological activity of compounds of the polyamine series, comparing their biological action with action on certain molecular targets. Due to the structural diversity of this group of substances, it is impossible to fully reflect the currently available data in one review. Therefore, in this work, the main attention is paid to the derivatives, acyclic saturated polyamines.Results. The following aspects are considered: biological functionality, biosynthesis and catabolism, cell transport, and localization of biogenic polyamines in the living systems. Structural analogs and derivatives of biogenic polyamines with antitumor, neuroprotective, antiarrhythmic, antiparasitic, antibacterial, and other biological activities are represented; the relationship between biological activity and the target of exposure is reflected. It was found that the nature of the substituent, the number of cationic centers, and the length of the polyamine chain have a great influence on the nature of the effect.Conclusions. At present, the use of polyamine structures is restrained by cytotoxicity and nonspecific toxic effects on the central nervous system. Further research in the field of biochemistry, cell transport, and a deeper understanding of receptor interaction mechanisms will help making polyamines as the basis for potential drug formulation.Цели. Биогенные полиамины широко представлены в живой природе. Они характерны как для клеток простейших, так и для многоклеточных организмов. Данные соединения обладают широким спектром биологической активности и необходимы для нормального роста и развития клеток. Нарушение гомеостаза полиаминов может вызывать существенные отклонения в функционировании клетки, провоцируя протекание патологических процессов различного рода, включая онкологические и психоневрологические заболевания. Воздействие на «полиаминовый путь» является привлекательным базисом для создания ряда фармакологически активных веществ с различным спектром действия. Целью данного обзора является обобщение результатов исследований, посвященных изучению биологической активности соединений полиаминового ряда; сопоставление биологического действия с воздействием на определенные молекулярные мишени. В виду структурного многообразия данной группы веществ невозможно в полной мере отразить имеющиеся на сегодняшний момент данные в одном обзоре. Поэтому в настоящей работе основное внимание уделено производным насыщенных полиаминов ациклического строения.Результаты. В общем виде рассмотрены следующие аспекты: биологическая активность, биосинтез и катаболизм, клеточный транспорт и локализация биогенных полиаминов в живых системах. Представлены структурные аналоги и производные биогенных полиаминов, обладающие противоопухолевой, нейропротекторной, антиаритмической, противопаразитарной, антибактериальной и некоторыми другими видам биологической активности; отражена взаимосвязь между биологической активностью и мишенями воздействия. Установлено, что на характер воздействия большое влияние оказывает природа заместителя, количество катионных центров, а также длина полиаминовой цепи.Выводы. В настоящее время применение структур полиаминового ряда сдерживается наличием цитотоксичности, а также неспецифического токсического воздействия на ЦНС. Дальнейшие исследования в области биохимии, клеточного транспорта, а также более глубокое понимание механизмов рецепторного взаимодействия позволят использовать полиамины в качестве основы для создания потенциальных лекарственных препаратов

Polysaccharide-derived mesoporous materials (Starbon®) for sustainable separation of complex mixtures

The recovery and separation of high value and low volume extractives are a considerable challenge for the commercial realisation of zero-waste biorefineries. Using solid-phase extractions (SPE) based on sustainable sorbents is a promising method to enable efficient, green and selective separation of these complex extractive mixtures. Mesoporous carbonaceous solids derived from renewable polysaccharides are ideal stationary phases due to their tuneable functionality and surface structure. In this study, the structure-separation relationships of thirteen polysaccharide-derived mesoporous materials and two modified types as sorbents for ten naturally-occurring bioactive phenolic compounds were investigated. For the first time, a comprehensive statistical analysis of the key molecular and surface properties influencing the recovery of these species was carried out. The obtained results show the possibility of developing tailored materials for purification, separation or extraction, depending on the molecular composition of the analyte. The wide versatility and application span of these polysaccharide-derived mesoporous materials offer new sustainable and inexpensive alternatives to traditional silica-based stationary phases

Syndrome of delay of prenatal height of fruit as risk of forming of kardiovaskulyarny pathology factor for children (review of literature)

The article is sanctified to the review of issue of the day in paediatrics: to development of kardiovaskulyarny violations for the children born with the syndrome of delay of antenatal height of fruit. Cited data about reasons, pathogeny and character of of kardiovaskulyarny violations at new-born and children of senior age.Статья посвящена обзору актуальной проблемы в педиатрии: развития кардиоваскулярных нарушений у детей, рожденных с синдромом задержки внутриутробного роста плода. Приводятся данные о причинах, патогенезе и характере кардиоваскулярных нарушений у новорожденных и детей старшего возраста