8 research outputs found

    Cyclic Variation of Residual (CO2 + H2O) and Total Pressure in Conifer Stem and Woody Root Tree Rings

    Get PDF
    Tree-ring chronologies of stem discs and core samples have been widely used to reconstruct the climatic conditions of tree growth. However, insufficient attention has been given to the fact that root and stem wood accumulate biogenic gases, whose distribution in annual rings can also be related to the climate-dependent features of tree growth. The study of chronologies of gas samples extracted under vacuum from the wood of tree-ring discs of the Siberian stone pine (Pinus sibirica Du Tour), Scots pine (Pinus sylvestris L.), Siberian larch (Larix sibirica Ledeb.) and Siberian spruce (Picea obovata Ledeb.) suggests that annual distributions of CO2 and H2O in the rings and pressure variation in extracted samples follow a cyclic pattern. It was found that the sample pressure and the content of CO2 and H2O in the annual rings in stems and roots of the Siberian stone pine and Scots pine from Tomsk (Russia) area are characterized by varied time cycles, including periods of about 4 and 11 years, the latter corresponding to the period of the solar activity cycle. The four-year cycle in the above chronologies is explained by the presence of similar cycles in temperature and precipitation chronologies, where cyclic variations of CO2 in the rings can be interpreted as a response of the plant to the change in the climatic conditions. The established cyclic variation of the pressure and CO2 content in tree rings in stems and roots indicates that CO2 release into the atmosphere should also follow a cyclic pattern. Therefore, to estimate correctly the release of CO2 by tree stems and large roots, long-term measurements are require

    ЦикличСскиС Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ остаточного (БО2 + Н2О) ΠΈ ΠΏΠΎΠ»Π½ΠΎΠ³ΠΎ давлСния Π² дрСвСсинС ΠΊΠΎΠ»Π΅Ρ† ствола ΠΈ корня Ρ…Π²ΠΎΠΉΠ½Ρ‹Ρ… Π΄Π΅Ρ€Π΅Π²ΡŒΠ΅Π²

    No full text
    Tree-ring chronologies of stem discs and core samples have been widely used to reconstruct the climatic conditions of tree growth. However, insufficient attention has been given to the fact that root and stem wood accumulate biogenic gases, whose distribution in annual rings can also be related to the climate-dependent features of tree growth. The study of chronologies of gas samples extracted under vacuum from the wood of tree-ring discs of the Siberian stone pine (Pinus sibirica Du Tour), Scots pine (Pinus sylvestris L.), Siberian larch (Larix sibirica Ledeb.) and Siberian spruce (Picea obovata Ledeb.) suggests that annual distributions of CO2 and H2O in the rings and pressure variation in extracted samples follow a cyclic pattern. It was found that the sample pressure and the content of CO2 and H2O in the annual rings in stems and roots of the Siberian stone pine and Scots pine from Tomsk (Russia) area are characterized by varied time cycles, including periods of about 4 and 11 years, the latter corresponding to the period of the solar activity cycle. The four-year cycle in the above chronologies is explained by the presence of similar cycles in temperature and precipitation chronologies, where cyclic variations of CO2 in the rings can be interpreted as a response of the plant to the change in the climatic conditions. The established cyclic variation of the pressure and CO2 content in tree rings in stems and roots indicates that CO2 release into the atmosphere should also follow a cyclic pattern. Therefore, to estimate correctly the release of CO2 by tree stems and large roots, long-term measurements are requiredДрСвСсно-ΠΊΠΎΠ»ΡŒΡ†Π΅Π²Ρ‹Π΅ Ρ…Ρ€ΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ спилов ΠΈ ΠΊΠ΅Ρ€Π½ΠΎΠ² Π΄Π΅Ρ€Π΅Π²ΡŒΠ΅Π² ΡˆΠΈΡ€ΠΎΠΊΠΎ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ΡΡ для рСконструкций климатичСских условий роста Π΄Π΅Ρ€Π΅Π²Π°. Однако остаСтся Π² сторонС Ρ‚ΠΎΡ‚ Ρ„Π°ΠΊΡ‚, Ρ‡Ρ‚ΠΎ дрСвСсина ΠΊΠΎΡ€Π½Π΅ΠΉ ΠΈ стволов сохраняСт Π²Π½ΡƒΡ‚Ρ€ΠΈ сСбя Π±ΠΈΠΎΠ³Π΅Π½Π½Ρ‹Π΅ Π³Π°Π·Ρ‹, распрСдСлСниС ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… ΠΏΠΎ Π³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹ΠΌ ΠΊΠΎΠ»ΡŒΡ†Π°ΠΌ Ρ‚Π°ΠΊΠΆΠ΅ ΠΌΠΎΠΆΠ΅Ρ‚ ΠΎΡ‚Ρ€Π°ΠΆΠ°Ρ‚ΡŒ климатичСскиС особСнности роста Π΄Π΅Ρ€Π΅Π²Π°. ИсслСдованиС Ρ…Ρ€ΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π³Π°Π·ΠΎΠ²Ρ‹Ρ… ΠΏΡ€ΠΎΠ±, ΠΈΠ·Π²Π»Π΅ΠΊΠ°Π΅ΠΌΡ‹Ρ… ΠΏΠΎΠ΄ Π²Π°ΠΊΡƒΡƒΠΌΠΎΠΌ ΠΈΠ· дрСвСсины Π³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹Ρ… ΠΊΠΎΠ»Π΅Ρ† спилов ΠΊΠ΅Π΄Ρ€Π° (Pinus sibirica Du Tour), сосны (Pinus sylvestris L.), листвСнницы (Larix sibirica Ledeb.), Π΅Π»ΠΈ (Picea obovata Ledeb), ΡƒΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚ Π½Π° Ρ‚ΠΎ, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠ³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹Π΅ распрСдСлСния ΡΠΎΡ…Ρ€Π°Π½ΠΈΠ²ΡˆΠΈΡ…ΡΡ Π² ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… БО2, Н2О ΠΈ Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ давлСния ΠΈΠ·Π²Π»Π΅ΠΊΠ°Π΅ΠΌΠΎΠΉ ΠΏΡ€ΠΎΠ±Ρ‹ носят цикличСский Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€. ΠžΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ±Ρ‹, содСрТаниС БО2 ΠΈ Н2О Π² Π³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹Ρ… ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… стволов ΠΈ ΠΊΠΎΡ€Π½Π΅ΠΉ ΠΊΠ΅Π΄Ρ€Π° ΠΈ сосны ΠΈΠ· Ρ€Π°ΠΉΠΎΠ½Π° Вомска (Россия) ΠΈΡΠΏΡ‹Ρ‚Ρ‹Π²Π°ΡŽΡ‚ Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Π²Ρ€Π΅ΠΌΠ΅Π½Π½Ρ‹Ρ… ΠΌΠ°ΡΡˆΡ‚Π°Π±ΠΎΠ², Π² Ρ‚ΠΎΠΌ числС Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ с ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π°ΠΌΠΈ ΠΎΠΊΠΎΠ»ΠΎ 4 ΠΈ 11 Π»Π΅Ρ‚, послСдний соотвСтствуСт ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Ρƒ Ρ†ΠΈΠΊΠ»Π° солнСчной активности. ПоявлСниС Ρ†ΠΈΠΊΠ»Π° с ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ΠΎΠΌ 4 Π³ΠΎΠ΄Π° Π² Π½Π°ΠΉΠ΄Π΅Π½Π½Ρ‹Ρ… хронологиях ΠΎΠ±ΡŠΡΡΠ½ΡΠ΅Ρ‚ΡΡ сущСствованиСм ΠΏΠΎΠ΄ΠΎΠ±Π½Ρ‹Ρ… Ρ†ΠΈΠΊΠ»ΠΎΠ² Π² хронологиях Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€ ΠΈ осадков, Π° цикличСскиС Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ рСгистрируСмого Π² ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… БО2 ΠΌΠΎΠΆΠ½ΠΎ ΡΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ Ρ€Π΅Π°ΠΊΡ†ΠΈΠ΅ΠΉ растСния Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ климатичСских условий. Из ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π½ΠΎΠΉ цикличСской Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ давлСния ΠΈ БО2 Π² ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… спилов стволов ΠΈ ΠΊΠΎΡ€Π½Π΅ΠΉ Π΄Π΅Ρ€Π΅Π²ΡŒΠ΅Π² слСдуСт, Ρ‡Ρ‚ΠΎ Π²Ρ‹Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π² атмосфСру БО2 Π΄ΠΎΠ»ΠΆΠ½ΠΎ Π½ΠΎΡΠΈΡ‚ΡŒ Ρ‚Π°ΠΊΠΆΠ΅ цикличСский Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€, поэтому для ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ‚Π½ΠΎΠΉ ΠΎΡ†Π΅Π½ΠΊΠΈ выдСлСния БО2 стволами ΠΈ ΠΊΡ€ΡƒΠΏΠ½Ρ‹ΠΌΠΈ корнями слСдуСт ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΡ‚ΡŒ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ ΠΈΠ·ΠΌΠ΅Ρ€Π΅Π½ΠΈ

    ЦикличСскиС Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ остаточного (БО2 + Н2О) ΠΈ ΠΏΠΎΠ»Π½ΠΎΠ³ΠΎ давлСния Π² дрСвСсинС ΠΊΠΎΠ»Π΅Ρ† ствола ΠΈ корня Ρ…Π²ΠΎΠΉΠ½Ρ‹Ρ… Π΄Π΅Ρ€Π΅Π²ΡŒΠ΅Π²

    Get PDF
    Tree-ring chronologies of stem discs and core samples have been widely used to reconstruct the climatic conditions of tree growth. However, insufficient attention has been given to the fact that root and stem wood accumulate biogenic gases, whose distribution in annual rings can also be related to the climate-dependent features of tree growth. The study of chronologies of gas samples extracted under vacuum from the wood of tree-ring discs of the Siberian stone pine (Pinus sibirica Du Tour), Scots pine (Pinus sylvestris L.), Siberian larch (Larix sibirica Ledeb.) and Siberian spruce (Picea obovata Ledeb.) suggests that annual distributions of CO2 and H2O in the rings and pressure variation in extracted samples follow a cyclic pattern. It was found that the sample pressure and the content of CO2 and H2O in the annual rings in stems and roots of the Siberian stone pine and Scots pine from Tomsk (Russia) area are characterized by varied time cycles, including periods of about 4 and 11 years, the latter corresponding to the period of the solar activity cycle. The four-year cycle in the above chronologies is explained by the presence of similar cycles in temperature and precipitation chronologies, where cyclic variations of CO2 in the rings can be interpreted as a response of the plant to the change in the climatic conditions. The established cyclic variation of the pressure and CO2 content in tree rings in stems and roots indicates that CO2 release into the atmosphere should also follow a cyclic pattern. Therefore, to estimate correctly the release of CO2 by tree stems and large roots, long-term measurements are requiredДрСвСсно-ΠΊΠΎΠ»ΡŒΡ†Π΅Π²Ρ‹Π΅ Ρ…Ρ€ΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ спилов ΠΈ ΠΊΠ΅Ρ€Π½ΠΎΠ² Π΄Π΅Ρ€Π΅Π²ΡŒΠ΅Π² ΡˆΠΈΡ€ΠΎΠΊΠΎ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ΡΡ для рСконструкций климатичСских условий роста Π΄Π΅Ρ€Π΅Π²Π°. Однако остаСтся Π² сторонС Ρ‚ΠΎΡ‚ Ρ„Π°ΠΊΡ‚, Ρ‡Ρ‚ΠΎ дрСвСсина ΠΊΠΎΡ€Π½Π΅ΠΉ ΠΈ стволов сохраняСт Π²Π½ΡƒΡ‚Ρ€ΠΈ сСбя Π±ΠΈΠΎΠ³Π΅Π½Π½Ρ‹Π΅ Π³Π°Π·Ρ‹, распрСдСлСниС ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… ΠΏΠΎ Π³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹ΠΌ ΠΊΠΎΠ»ΡŒΡ†Π°ΠΌ Ρ‚Π°ΠΊΠΆΠ΅ ΠΌΠΎΠΆΠ΅Ρ‚ ΠΎΡ‚Ρ€Π°ΠΆΠ°Ρ‚ΡŒ климатичСскиС особСнности роста Π΄Π΅Ρ€Π΅Π²Π°. ИсслСдованиС Ρ…Ρ€ΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π³Π°Π·ΠΎΠ²Ρ‹Ρ… ΠΏΡ€ΠΎΠ±, ΠΈΠ·Π²Π»Π΅ΠΊΠ°Π΅ΠΌΡ‹Ρ… ΠΏΠΎΠ΄ Π²Π°ΠΊΡƒΡƒΠΌΠΎΠΌ ΠΈΠ· дрСвСсины Π³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹Ρ… ΠΊΠΎΠ»Π΅Ρ† спилов ΠΊΠ΅Π΄Ρ€Π° (Pinus sibirica Du Tour), сосны (Pinus sylvestris L.), листвСнницы (Larix sibirica Ledeb.), Π΅Π»ΠΈ (Picea obovata Ledeb), ΡƒΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚ Π½Π° Ρ‚ΠΎ, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠ³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹Π΅ распрСдСлСния ΡΠΎΡ…Ρ€Π°Π½ΠΈΠ²ΡˆΠΈΡ…ΡΡ Π² ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… БО2, Н2О ΠΈ Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ давлСния ΠΈΠ·Π²Π»Π΅ΠΊΠ°Π΅ΠΌΠΎΠΉ ΠΏΡ€ΠΎΠ±Ρ‹ носят цикличСский Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€. ΠžΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ±Ρ‹, содСрТаниС БО2 ΠΈ Н2О Π² Π³ΠΎΠ΄ΠΈΡ‡Π½Ρ‹Ρ… ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… стволов ΠΈ ΠΊΠΎΡ€Π½Π΅ΠΉ ΠΊΠ΅Π΄Ρ€Π° ΠΈ сосны ΠΈΠ· Ρ€Π°ΠΉΠΎΠ½Π° Вомска (Россия) ΠΈΡΠΏΡ‹Ρ‚Ρ‹Π²Π°ΡŽΡ‚ Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Π²Ρ€Π΅ΠΌΠ΅Π½Π½Ρ‹Ρ… ΠΌΠ°ΡΡˆΡ‚Π°Π±ΠΎΠ², Π² Ρ‚ΠΎΠΌ числС Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ с ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π°ΠΌΠΈ ΠΎΠΊΠΎΠ»ΠΎ 4 ΠΈ 11 Π»Π΅Ρ‚, послСдний соотвСтствуСт ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Ρƒ Ρ†ΠΈΠΊΠ»Π° солнСчной активности. ПоявлСниС Ρ†ΠΈΠΊΠ»Π° с ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ΠΎΠΌ 4 Π³ΠΎΠ΄Π° Π² Π½Π°ΠΉΠ΄Π΅Π½Π½Ρ‹Ρ… хронологиях ΠΎΠ±ΡŠΡΡΠ½ΡΠ΅Ρ‚ΡΡ сущСствованиСм ΠΏΠΎΠ΄ΠΎΠ±Π½Ρ‹Ρ… Ρ†ΠΈΠΊΠ»ΠΎΠ² Π² хронологиях Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€ ΠΈ осадков, Π° цикличСскиС Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ рСгистрируСмого Π² ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… БО2 ΠΌΠΎΠΆΠ½ΠΎ ΡΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ Ρ€Π΅Π°ΠΊΡ†ΠΈΠ΅ΠΉ растСния Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ климатичСских условий. Из ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π½ΠΎΠΉ цикличСской Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ давлСния ΠΈ БО2 Π² ΠΊΠΎΠ»ΡŒΡ†Π°Ρ… спилов стволов ΠΈ ΠΊΠΎΡ€Π½Π΅ΠΉ Π΄Π΅Ρ€Π΅Π²ΡŒΠ΅Π² слСдуСт, Ρ‡Ρ‚ΠΎ Π²Ρ‹Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π² атмосфСру БО2 Π΄ΠΎΠ»ΠΆΠ½ΠΎ Π½ΠΎΡΠΈΡ‚ΡŒ Ρ‚Π°ΠΊΠΆΠ΅ цикличСский Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€, поэтому для ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ‚Π½ΠΎΠΉ ΠΎΡ†Π΅Π½ΠΊΠΈ выдСлСния БО2 стволами ΠΈ ΠΊΡ€ΡƒΠΏΠ½Ρ‹ΠΌΠΈ корнями слСдуСт ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΡ‚ΡŒ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ ΠΈΠ·ΠΌΠ΅Ρ€Π΅Π½ΠΈ

    TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen

    No full text
    Objective: TMC125, a next generation, non-nucleoside reverse transcriptase inhibitor (NNRTI), demonstrated a remarkable decline of plasma HIV-1 RNA during a phase IIa study. We compared the initial rate of decline of plasma HIV-1 RNA achieved by TMC125 monotherapy with that of a triple class, five-drug regimen, containing drugs from all three currently licensed classes (zidovudine, lamivudine, abacavir, indinavir and nevirapine). Methods: The decline in plasma HIV-1 RNA of 12 HIV-1 infected, antiretroviral (ART) naive patients treated for 1 week with TMC125 monotherapy was compared with that observed in the ERA study (n = 11). The plasma HIV-1 RNA elimination rate constant was calculated based on at least four plasma HIV-1 RNA measurements during the first week of treatment (first-order elimination) and compared using the Student's t test. Results: Median ages were 23 and 38 years for TMC125 and ERA patients, respectively (P = 0.001), median baseline plasma HIV-1 RNA levels were 4.2 and 4.8 log10 copies/ml (P = 0.001) and median baseline CD4 T-cell counts were 458 Γ— 106 and 360 Γ— 106 cells/l (P = 0.08). The median plasma HIV-1 RNA elimination rate constant was 0.68/day in TMC125 treated patients, and 0.56/day in ERA participants (P = 0.24). The median decline in plasma HIV-1 RNA after 7 days was 1.92 and 1.76 log 10 copies (P = 0.77) and the median increase of CD4 T cells was 119 Γ— 106 and 60 Γ— 106 cells/l, respectively (P = 0.29). Conclusion: Monotherapy with TMC125 in ART-naive, HIV-1-infected individuals resulted in a similar rate of decline of plasma HIV-1 RNA during 1 week of therapy as therapy with a five-drug regimen

    TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen

    No full text
    Objective: TMC125, a next generation, non-nucleoside reverse transcriptase inhibitor (NNRTI), demonstrated a remarkable decline of plasma HIV-1 RNA during a phase IIa study. We compared the initial rate of decline of plasma HIV-1 RNA achieved by TMC125 monotherapy with that of a triple class, five-drug regimen, containing drugs from all three currently licensed classes (zidovudine, lamivudine, abacavir, indinavir and nevirapine). Methods: The decline in plasma HIV-1 RNA of 12 HIV-1 infected, antiretroviral (ART) naive patients treated for 1 week with TMC125 monotherapy was compared with that observed in the ERA study (n = 11). The plasma HIV-1 RNA elimination rate constant was calculated based on at least four plasma HIV-1 RNA measurements during the first week of treatment (first-order elimination) and compared using the Student's t test. Results: Median ages were 23 and 38 years for TMC125 and ERA patients, respectively (P = 0.001), median baseline plasma HIV-1 RNA levels were 4.2 and 4.8 log(10) copies/ml (P = 0.001) and median baseline CD4 T-cell counts were 458 X 10(6) and 360 X 10(6) cells/l (P = 0.08). The median plasma HIV-1 RNA elimination rate constant was 0.68/day in TMC125 treated patients, and 0.56/day in ERA participants (P = 0.24). The median decline in plasma HIV-1 RNA after 7 days was 1.92 and 1.76 log(10) copies (P = 0.77) and the median increase of CD4 T cells was 119 X 10(6) and 60 X 106 cells/l, respectively (P = 0.29). Conclusion: Monotherapy with TMC125 in ART-naive, HIV-1-infected individuals resulted in a similar rate of decline of plasma HIV-1 RNA during 1 week of therapy as therapy with a five-drug regimen. (C) 2003 Lippincott Williams Wilkin

    Occurrences of Threatened Species included in the Third Edition of the Red Data Book of the Komi Republic (Russia)

    No full text
    The purpose of the data paper was to introduce into scientific literature the results of scientific work carried out for the third edition of the 'Red Data Book of the Komi Republic'. The article reflects methodological approaches to the formation of a list of rare and in need of protection species and describes the corresponding datasets published in GBIF.Information about 7,187 occurrences of 438 rare species and infraspecies included in the third edition of the 'Red Data Book of the Komi Republic' have been published

    Cangrelor With and Without GlycoproteinΒ IIb/IIIa Inhibitors inΒ PatientsΒ Undergoing PercutaneousΒ Coronary Intervention

    No full text
    corecore