Cerebral Lateralization and Cognitive Function

Eighty-seven undergraduate students were given the Edinburgh Handedness Inventory, two dichotic listening tasks, and a paired-associate task to assess the relationship between visuo-spatial/verbal abilities and cerebral lateralization. It was hypothesized that well lateralized subjects, as measured by the handedness inventory and dichotic listening tasks, would score higher in the visual imagery condition of the pairedassociate task than less well lateralized subjects * and would score about the same as the less well lateralized subjects on the verbal mediation condition. According to the Levy-Sperry hypothesis the less well lateralized subjects should have experienced difficulty using visual imagery mneumonics on the paired-associate task due to the interference from language processes in the left hemisphere. The results failed to support the Levy-Sperry hypothesis in that there were no significant differences between handedness or cerebral dominance groups. The differences between the hypotheses and results were attributed to defects in experimental i procedure and several possible improvements in procedure were discussed

The Grizzly, September 17, 1982

New Ursinus Students Welcomed • Lantern Needs Associate Editor • Vandalism at Myrin • Administration Alterations • Committee Needs Chairmen • Folk Festival Summer Fun • Forum Preview • Lewis on Wall Street • Fencing Anyone? • Sendai Students at UC • Changes in Wismer • USGA Notes • Field Hockey Falls to Trenton State • The Bear Pack is in Top Form, Again • Volleyball Dumps Del Val • Grizzlies Drop Football Opener • Soccer Team Loses Two Close Oneshttps://digitalcommons.ursinus.edu/grizzlynews/1081/thumbnail.jp

Combination of cytokine responses indicative of latent TB and active TB in Malawian adults.

BACKGROUND: An IFN-γ response to M. tuberculosis-specific antigens is an effective biomarker for M. tuberculosis infection but it cannot discriminate between latent TB infection and active TB disease. Combining a number of cytokine/chemokine responses to M. tuberculosis antigens may enable differentiation of latent TB from active disease. METHODS: Asymptomatic recently-exposed individuals (spouses of TB patients) were recruited and tuberculin skin tested, bled and followed-up for two years. Culture supernatants, from a six-day culture of diluted whole blood samples stimulated with M. tuberculosis-derived PPD or ESAT-6, were measured for IFN-γ, IL-10, IL-13, IL-17, TNF-α and CXCL10 using cytokine ELISAs. In addition, 15 patients with sputum smear-positive pulmonary TB were recruited and tested. RESULTS: Spouses with positive IFN-γ responses to M. tuberculosis ESAT-6 (>62.5 pg/mL) and TB patients showed high production of IL-17, CXCL10 and TNF-α. Higher production of IL-10 and IL-17 in response to ESAT-6 was observed in the spouses compared with TB patients while the ratios of IFN-γ/IL-10 and IFN-γ/IL-17 in response to M. tuberculosis-derived PPD were significantly higher in TB patients compared with the spouses. Tuberculin skin test results did not correlate with cytokine responses. CONCLUSIONS: CXCL10 and TNF-α may be used as adjunct markers alongside an IFN-γ release assay to diagnose M. tuberculosis infection, and IL-17 and IL-10 production may differentiate individuals with LTBI from active TB