Acute effects of night-time noise exposure on blood pressure in populations living near airports

AIMS: Within the framework of the HYENA (hypertension and exposure to noise near airports) project we investigated the effect of short-term changes of transportation or indoor noise levels on blood pressure (BP) and heart rate (HR) during night-time sleep in 140 subjects living near four major European airports. METHODS AND RESULTS: Non-invasive ambulatory BP measurements at 15 min intervals were performed. Noise was measured during the night sleeping period and recorded digitally for the identification of the source of a noise event. Exposure variables included equivalent noise level over 1 and 15 min and presence/absence of event (with LAmax > 35 dB) before each BP measurement. Random effects models for repeated measurements were applied. An increase in BP (6.2 mmHg (0.63-12) for systolic and 7.4 mmHg (3.1, 12) for diastolic) was observed over 15 min intervals in which an aircraft event occurred. A non-significant increase in HR was also observed (by 5.4 b.p.m.). Less consistent effects were observed on HR. When the actual maximum noise level of an event was assessed there were no systematic differences in the effects according to the noise source. CONCLUSION: Effects of noise exposure on elevated subsequent BP measurements were clearly shown. The effect size of the noise level appears to be independent of the noise source

Personal exposure to PM2.5 among high-school students in Milan and background measurements: The EuroLifeNet study

As part of the EuroLifeNet program we measured personal exposure to PM2.5 in 90 pupils attending three schools in Milan, over a three-week period spanning November and December 2006, using a portable light-scattering nephelometer. The primary aim was to investigate the relationship between personal exposure to PM2.5 and background measurements obtained from a fixed monitoring station. Pearson’s correlation coefficient between sampled daily mean exposures and reference values from background station varied from 0.64 to 0.75, with an overall value of 0.63, indicating good agreement. We also estimated that about 40% of the variability in the mean daily personal exposure at the three schools was due to variability in background exposure, the remaining 60% due to between-subject differences in exposures or to other sources of error.JRC.C.5-Air and Climat

Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs

The marine natural product Largazole is the most potent Class I HDAC inhibitor identified to date. Since its discovery, many research groups have been attracted by the structural complexity and the peculiar anticancer activity, due to its capability to discriminate between tumor cells and normal cells. Herein, we discuss the synthesis and the in vitro biological profile of hybrid analogues of Largazole, as dual HDAC inhibitor and nitric oxide (NO) donors, potentially useful as anticancer agents. In particular, the metabolic stability of the modified thioester moiety of Largazole, bearing the NO-donor function/s, the in vitro release of NO, and the antiproliferative activity in tumor cell lines are presented

QUANTIFICATION OF HEALTH EFFECTS OF EXPOSURE TO AIR POLLUTION (PM10) IN TABRIZ, IRAN

International audienceEpidemiological studies show that long-term exposure to PM is associated with an increased risk of cancer or cardiovascular and respiratory diseases. The main objective of the present study was the assessment of health outcomes related to PM10 (particulate matter (PM) of aerodynamic diameter <= 10 mu m) exposure in Tabriz, Iran. Related health impacts (relative risk and baselineincidence) due to exposure to PM10 in the city of Tabriz were assessed by using the well-established AirQ2.2.3 model by the World Health Organization European Center for Environment Health. We estimated that out of 15,651 total deaths in the city, 7679 and 1020 people died due to cardiovascular and respiratory related deaths respectively. Among the 19,467 people admitted to hospital due to respiratory disease, 1114 diseases could be attributed to PM10. According to this model, cases of natural mortality, cardiovascular deaths and respiratory mortality caused by PM10 were about 832, 439, and 85, respectively

Enzyme encapsulation in Water/Water Pickering emulsion vesicles stabilized by Layered Double Hydroxides nanoparticles.

International audienc

Acute effects of night-time noise exposure on blood pressure in populations living near airports

AimsWithin the framework of the HYENA (hypertension and exposure to noise near airports) project we investigated the effect of short-term changes of transportation or indoor noise levels on blood pressure (BP) and heart rate (HR) during night-time sleep in 140 subjects living near four major European airports.Methods and resultsNon-invasive ambulatory BP measurements at 15 min intervals were performed. Noise was measured during the night sleeping period and recorded digitally for the identification of the source of a noise event. Exposure variables included equivalent noise level over 1 and 15 min and presence/absence of event (with LAmax &gt; 35 dB) before each BP measurement. Random effects models for repeated measurements were applied. An increase in BP (6.2 mmHg (0.63-12) for systolic and 7.4 mmHg (3.1, 12) for diastolic) was observed over 15 min intervals in which an aircraft event occurred. A non-significant increase in HR was also observed (by 5.4 b.p.m.). Less consistent effects were observed on HR. When the actual maximum noise level of an event was assessed there were no systematic differences in the effects according to the noise source.ConclusionEffects of noise exposure on elevated subsequent BP measurements were clearly shown. The effect size of the noise level appears to be independent of the noise source. © 2008. The European Society of Cardiology All rights reserved

Hypertension and exposure to noise near airports: The HYENA study

Background: An increasing number of people are exposed to aircraft and road traffic noise. Hypertension is an important risk factor for cardiovascular disease, and even a small contribution in risk from environmental factors may have a major impact on public health. Objectives: The HYENA (Hypertension and Exposure to Noise near Airports) study aimed to assess the relations between noise from aircraft or road traffic near airports and the risk of hypertension. Methods: We measured blood pressure and collected data on health, socioeconomic, and lifestyle factors, including diet and physical activity, via questionnaire at home visits for 4,861 persons 45-70 years of age, who had lived at least 5 years near any of six major European airports. We assessed noise exposure using detailed models with a resolution of 1 dB (5 dB for United Kingdom road traffic noise), and a spatial resolution of 250 × 250 m for aircraft and 10 × 10 m for road traffic noise. Results: We found significant exposure-response relationships between night-time aircraft as well as average daily road traffic noise exposure and risk of hypertension after adjustment for major confounders. For night-time aircraft noise, a 10-dB increase in exposure was associated with an odds ratio (OR) of 1.14 [95% confidence interval (CI), 1.01-1.29]. The exposure-response relationships were similar for road traffic noise and stronger for men with an OR of 1.54 (95% CI, 0.99-2.40) in the highest exposure category (&amp;gt; 65 dB; ptrend = 0.008). Conclusions: Our results indicate excess risks of hypertension related to long-term noise exposure, primarily for night-time aircraft noise and daily average road traffic noise