Characterizing the Hadley circulation response through regional climate feedbacks

The robust weakening of the tropical atmospheric circulation in projections of anthropogenic warming is associated with substantial changes in regional and global climate. The present study focuses on understanding the response of the annual-mean Hadley circulation from a perspective of interactions between climate feedbacks and tropical circulation. Simulations from an ensemble of coupled ocean–atmosphere models are used to quantify changes in Hadley cell strength in terms of feedbacks, radiative forcing, ocean heat uptake, atmospheric eddies, and gross moist stability. Climate feedbacks are calculated for the model integrations from phase 5 of CMIP (CMIP5) using radiative kernels. Tropical mean circulation is found to be reduced by up to 2.6% K^(−1) for an abrupt quadrupling of carbon dioxide concentration. The weakening is characterized by an increase in gross moist stability, by an increase in eddy heat flux, and by positive extratropical feedbacks, such as those associated with lapse rate and sea ice response. Understanding the impact of radiative feedbacks on the large-scale circulation provides a framework for constraining uncertainty in the dynamic climate response, including the hydrological cycle

The effects of orbital precession on tropical precipitation: Mechanisms controlling precipitation changes over land and ocean

The tropical precipitation response to precessional forcing is investigated using idealized precession experiments from the Geophysical Fluid Dynamics Laboratory Coupled Model version 2.1 and mid-Holocene experiments from ten general circulation models participating in the Paleoclimate Modeling Intercomparison Project Phase III. Both sets of experiments show a seasonal land-ocean asymmetry in the tropical precipitation response: precipitation increases over land and decreases over ocean in the season with increased insolation and the opposite is true in the season with decreased insolation. This response is examined using a framework that describes how changes in net top-of-atmosphere radiation affect the atmosphere and surface energy balances. Over land, surface energy storage is small and changes in precipitation are balanced by changes in moist static energy flux divergence. Over ocean, surface energy storage is large, moist static energy flux divergence is small, and changes in precipitation are ultimately driven by changes in circulation and atmospheric stability

Towards cyber-physical systems as services: the ASIP protocol

The development of Cyber-Physical Systems needs to address the heterogeneity of several components that interact to build a single application. In this paper we present a model to enable easy integration and interaction of micro-controllers. Specifically, we describe the Arduino Service Interface Protocol (ASIP), we provide an implementation and client libraries for Java, Racket and Erlang, together with the description of a practical example

Low-energy excitations of a linearly Jahn-Teller coupled orbital quintet

The low-energy spectra of the single-mode h x (G+H) linear Jahn-Teller model is studied by means of exact diagonalization. Both eigenenergies and photoemission spectral intensities are computed. These spectra are useful to understand the vibronic dynamics of icosahedral clusters with partly filled orbital quintet molecular shells, for example C60 positive ions.Comment: 14 pages revte

Improving spatial landslide prediction with 3d slope stability analysis and genetic algorithm optimization: Application to the oltrepò pavese

In this study, we compare infinite slope and the three-dimensional stability analysis performed by SCOOPS 3D (software to analyze three-dimensional slope stability throughout a digital landscape). SCOOPS 3D is a model proposed by the U. S. Geological Survey (USGS), the potentialities of which have still not been investigated sufficiently. The comparison between infinite slope and 3D slope stability analysis is carried out using the same hydrological analysis, which is performed with TRIGRS (transient rainfall infiltration and grid-based regional slope-stability model)—another model proposed by USGS. The SCOOPS 3D model requires definition of a series of numerical parameters that can have a significant impact on its own performance, for a given set of physical properties. In the study, we calibrate these numerical parameters through a multi-objective optimization based on genetic algorithms to maximize the model predictability performance in terms of statistics of the receiver operating characteristics (ROC) confusion matrix. This comparison is carried out through an application on a real case study, a catchment in the Oltrepò Pavese (Italy), in which the areas of triggered landslides were accurately monitored during an extreme rainfall on 27–28 April 2009. Results show that the SCOOPS 3D model performs better than the 1D infinite slope stability analysis, as the ROC True Skill Statistic increases from 0.09 to 0.37. In comparison to other studies, we find the 1D model performs worse, likely for the availability of less detailed geological data. On the other side, for the 3D model we find even better results than the two other studies present to date in the scientific literature. This is to be attributed to the optimization process we proposed, which allows to have a greater gain of performance passing from the 1D to the 3D simulation, in comparison to the above-mentioned studies, where no optimization has been applied. Thus, our study contributes to improving the performances of landslide models, which still remain subject to many uncertainty factors

Algebraic-matrix calculation of vibrational levels of triatomic molecules

We introduce an accurate and efficient algebraic technique for the computation of the vibrational spectra of triatomic molecules, of both linear and bent equilibrium geometry. The full three-dimensional potential energy surface (PES), which can be based on entirely {\it ab initio} data, is parameterized as a product Morse-cosine expansion, expressed in bond-angle internal coordinates, and includes explicit interactions among the local modes. We describe the stretching degrees of freedom in the framework of a Morse-type expansion on a suitable algebraic basis, which provides exact analytical expressions for the elements of a sparse Hamiltonian matrix. Likewise, we use a cosine power expansion on a spherical harmonics basis for the bending degree of freedom. The resulting matrix representation in the product space is very sparse and vibrational levels and eigenfunctions can be obtained by efficient diagonalization techniques. We apply this method to carbonyl sulfide OCS, hydrogen cyanide HCN, water H$_2$O, and nitrogen dioxide NO$_2$. When we base our calculations on high-quality PESs tuned to the experimental data, the computed spectra are in very good agreement with the observed band origins.Comment: 11 pages, 2 figures, containg additional supporting information in epaps.ps (results in tables, which are useful but not too important for the paper

Synthesis of novel structural hybrids between aza-heterocycles and azelaic acid moiety with a specific activity on osteosarcoma cells

Nine compounds bearing pyridinyl (or piperidinyl, benzimidazolyl, benzotriazolyl) groups bound to an azelayl moiety through an amide bond were synthesized. The structural analogy with some histone deacetylase inhibitors inspired their syntheses, seeking new selective histone deacetylase inhibitors (HDACi). The azelayl moiety recalls part of 9-hydroxystearic acid, a cellular lipid showing antiproliferative activity toward cancer cells with HDAC as a molecular target. Azelayl derivatives bound to a benzothiazolyl moiety further proved to be active as HDACi. The novel compounds were tested on a panel of both normal and tumor cell lines. Non-specific induction of cytotoxicity was observed in the normal cell line, while three of them induced a biological effect only on the osteosarcoma (U2OS) cell line. One of them induced a change in nuclear shape and size. Cell-cycle alterations are associated with post-transcriptional modification of both H2/H3 and H4 histones. In line with recent studies, revealing unexpected HDAC7 function in osteoclasts, molecular docking studies on the active molecules predicted their proneness to interact with HDAC7. By reducing side effects associated with the action of the first-generation inhibitors, the herein reported compounds, thus, sound promising as selective HDACi

Variation in survival after diagnosis of breast cancer in Switzerland

Background: Survival after diagnosis of cancer is a key criterion for cancer control. Major survival differences between time periods and countries have been reported by the EUROCARE studies. We investigated whether similar differences by period and region existed in Switzerland. Methods: Survival of 11 376 cases of primary invasive female breast cancer diagnosed between 1988 and 1997 and registered in seven Swiss cancer registries covering a population of 3.5 million was analysed. Results: Comparing the two periods 1988-1992 and 1993-1997, age-standardized 5 year relative survival improved globally from 77% to 81%. Furthermore, multivariate analysis adjusting for age, tumour size and nodal involvement identified regional survival differences. Survival was lowest in the rural parts of German-speaking eastern Switzerland and highest in urbanised regions of the Latin- and German-speaking northwestern parts of the country. Conclusions: This study confirms that survival differences are present even in a small and affluent, but culturally diverse, country like Switzerland, raising the issue of heterogeneity in access to care and quality of treatmen

Synthesis and Antiproliferative Insights of Lipophilic Ru(II)-Hydroxy Stearic Acid Hybrid Species

Metallodrugs represent a combination of multifunctionalities that are present concomitantly and can act differently on diverse biotargets. Their efficacy is often related to the lipophilic features exhibited both by long carbo-chains and the phosphine ligands. Three Ru(II) complexes containing hydroxy stearic acids (HSAs) were successfully synthesized in order to evaluate possible synergistic effects between the known antitumor activity of HSA bio-ligands and the metal center. HSAs were reacted with [Ru(H)2CO(PPh3)3] selectively affording O,O-carboxy bidentate complexes. The organometallic species were fully characterized spectroscopically using ESI-MS, IR, UV-Vis, and NMR techniques. The structure of the compound Ru-12-HSA was also determined using single crystal X-ray diffraction. The biological potency of ruthenium complexes (Ru-7-HSA, Ru-9-HSA, and Ru-12-HSA) was studied on human primary cell lines (HT29, HeLa, and IGROV1). To obtain detailed information about anticancer properties, tests for cytotoxicity, cell proliferation, and DNA damage were performed. The results demonstrate that the new ruthenium complexes, Ru-7-HSA and Ru-9-HSA, possess biological activity. Furthermore, we observed that the Ru-9-HSA complex shows increased antitumor activity on colon cancer cells, HT29