45 research outputs found
Synthesis of thiodisaccharides by photoinduced hydrothiolation of 2-acetoxy glycals
Here, we present the synthesis of α-D-galactopyranosyl and α-L-fucopyranosyl thiodisaccharides 5-8 by the photoinitiated thiol-ene reactions of 2-acetoxy-3,4,6-tri-O-acetyl-D-galactal 1 and 2-acetoxy-3,4-di-O-acetyl-L-fucal 2 with thiols 3 and 4
Promoting SME cooperative aggregations: main criteria and contractual models
Collaboration is considered an effective solution to improve business strategies. However, small and medium enterprises (SMEs) often lack common principles and common forms of contractual coordination. Several policies implemented by the EU have addressed the set-up of a comprehensive SME policy framework, but European institutions seem to have focused more on organisational devices to conduct business activities rather than on contractual forms of coordination. In April 2009, Italy adopted a law in network contract to promote the development of inter-firm cooperation strategies to foster enterprises' innovation and growth. Even if this law represents a novelty in Europe and may offer new challenges and hints, it still presents some lacks in its formulation. The current research aims at presenting the Italian law for network contract and a comparison with other models of SME aggregations adopted in EU countries. A formal model to support the design of an SME network was proposed, by providing both an ontology-based model to help the definition of the contract in a structured way, and a basic workflow to identify the important phases of the network design, i.e. the feasibility study and the negotiatio
New localities of the subendemic species Berberis croatica, Teucrium arduini and Micromeria croatica in the Dinaric Alps
New localities of three subendemic species (Berberis croatica, Teucrium arduini and Micromeria croatica) have been found in the Dinaric Alps. Berberis croatica was found at ten new locations, nine of them in Croatia and one in Bosnia and Herzegovina. Teucrium arduini was found on Mt UÄŤka, Mt Velebit, Mt Biokovo and Mt SnijeĹľnica, at nine new locations while Micromeria croatica was found at four new locations, only on Mt Velebit
Association Between Common Cardiovascular Risk Factors and Clinical Phenotype in Patients with Hypertrophic Cardiomyopathy From the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis Registry
The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry.1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI) and clinical traits was analyzed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene.The prevalence of HT, DM and obesity (Ob) was 37%, 10%, and 21%, respectively. HT, DM and Ob were associated with older age (p<0.001), less family history of HCM (HT and DM p<0.001), higher New York Heart Association (NYHA) class (p<0.001), atrial fibrillation (HT and DM p<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob p<0.001; DM p = 0.003). Stroke was more frequent in HT (p<0.001) and mutation-positive patients with DM (p = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT p<0.001, Ob p = 0.036). LV hypertrophy was more severe in Ob (p = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, p = 0.017 and OR 1.584, p = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients.Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits
FĂ©nyemittálĂł maleinimid tartalmĂş polimerek előállĂtása Ă©s vizsgálata
Fluoreszcens tulajdonságokkal rendelkezĹ‘ maleimid tartalmĂş alapláncokat szintetizáltunk. Az előállĂtott monomereket (akril-származĂ©kok) gyökös mĂłdszerrel polimerizáltuk. A fluoreszcens termĂ©keket tisztĂtottuk Ă©s rĂ©szletesen karakterizáltuk NMR, GPC Ă©s tömegspektrometriás mĂ©rĂ©sekkel. Az elvĂ©gzett optikai vizsgálatok kimutatták, hogy az előállĂtott monomerek Ă©s polimerek, az oldat elkĂ©szĂtĂ©sĂ©nĂ©l használt oldĂłszer polaritásátĂłl fĂĽggĹ‘en, zöld vagy sárga fĂ©nyt emittálnak