APPEAL AND ERROR-UNION OF LAW AND EQUITY-APPEALABILITY OF ORDER DENYING DEMAND FOR JURY TRIAL

Defendant held an insurance policy written by plaintiff which by its terms covered a hangar against loss by fire. After the hangar had been destroyed by fire, plaintiff instituted this suit for reformation on the ground that the contract had been written as a fire policy through mutual mistake. Defendant denied the mistake, filed a counterclaim to recover on the policy as written, and demanded a jury trial. Plaintiff moved to strike the demand, and the motion was granted. The court of appeals dismissed the defendant\u27s appeal. On certiorari, held, affirmed. Not being a final decision, the order denying the motion is appealable, if at all, only as an interlocutory decree granting or refusing an injunction under §129 of the Judicial Code. But §129 is not applicable because the denial of a demand for jury trial is simply a determination as to the manner in which the court will try one issue in a civil action pending before it. City of Morgantown, West Virginia v. Royal Insurance Co. Ltd., 337 U.S. 254, 69 S.Ct. 1067 (1949)

A dendritic mechanism for decoding traveling waves: Principles and applications to motor cortex

Traveling waves of neuronal oscillations have been observed in many cortical regions, including the motor and sensory cortex. Such waves are often modulated in a task-dependent fashion although their precise functional role remains a matter of debate. Here we conjecture that the cortex can utilize the direction and wavelength of traveling waves to encode information. We present a novel neural mechanism by which such information may be decoded by the spatial arrangement of receptors within the dendritic receptor field. In particular, we show how the density distributions of excitatory and inhibitory receptors can combine to act as a spatial filter of wave patterns. The proposed dendritic mechanism ensures that the neuron selectively responds to specific wave patterns, thus constituting a neural basis of pattern decoding. We validate this proposal in the descending motor system, where we model the large receptor fields of the pyramidal tract neurons — the principle outputs of the motor cortex — decoding motor commands encoded in the direction of traveling wave patterns in motor cortex. We use an existing model of field oscillations in motor cortex to investigate how the topology of the pyramidal cell receptor field acts to tune the cells responses to specific oscillatory wave patterns, even when those patterns are highly degraded. The model replicates key findings of the descending motor system during simple motor tasks, including variable interspike intervals and weak corticospinal coherence. By additionally showing how the nature of the wave patterns can be controlled by modulating the topology of local intra-cortical connections, we hence propose a novel integrated neuronal model of encoding and decoding motor commands

The generation of hierarchic structures via robust 3D topology optimisation

Commonly used building structures often show a hierarchic layout of structural elements. It can be questioned whether such a layout originates from practical considerations, e.g. related to its construction, or that it is (relatively) optimal from a structural point of view. This paper investigates this question by using topology optimisation in an attempt to generate hierarchical structures. As an arbitrarily standard design case, the principle of a traditional timber floor that spans in one direction is used. The optimisation problem is first solved using classical sensitivity and density filtering. This leads indeed to solutions with a hierarchic layout, but they are practically unusable as the floor boarding is absent. A Heaviside projection is therefore considered next, but this does not solve the problem. Finally, a robust approach is followed, and this does result in a design similar to floor boarding supported by timber joists. The robust approach is then followed to study a floor with an opening, two floors that span in two directions, and an eight-level concrete building. It can be concluded that a hierarchic layout of structural elements likely originates from being optimal from a structural point of view. Also clear is that this conclusion cannot be obtained by means of standard topology optimisation based on sensitivity or density filtering (as often found in commercial finite element codes); robust 3D optimisation is required to obtain a usable, constructible (or in the future: 3D printable) structural design, with a crisp black-and-white density distribution

Incorporating Historical Models with Adaptive Bayesian Updates

This paper considers Bayesian approaches for incorporating information from a historical model into a current analysis when the historical model includes only a subset of covariates currently of interest. The statistical challenge is two-fold. First, the parameters in the nested historical model are not generally equal to their counterparts in the larger current model, neither in value nor interpretation. Second, because the historical information will not be equally informative for all parameters in the current analysis, additional regularization may be required beyond that provided by the historical information. We propose several novel extensions of the so-called power prior that adaptively combine a prior based upon the historical information with a variance-reducing prior that shrinks parameter values toward zero. The ideas are directly motivated by our work building mortality risk prediction models for pediatric patients receiving extracorporeal membrane oxygenation, or ECMO. We have developed a model on a registry-based cohort of ECMO patients and now seek to expand this model with additional biometric measurements, not available in the registry, collected on a small auxiliary cohort. Our adaptive priors are able to leverage the efficiency of the original model and identify novel mortality risk factors. We support this with a simulation study, which demonstrates the potential for efficiency gains in estimation under a variety of scenarios

Inferring a consensus problem list using penalized multistage models for ordered data

A patient\u27s medical problem list describes his or her current health status and aids in the coordination and transfer of care between providers, among other things. Because a problem list is generated once and then subsequently modified or updated, what is not usually observable is the provider-effect. That is, to what extent does a patient\u27s problem in the electronic medical record actually reflect a consensus communication of that patient\u27s current health status? To that end, we report on and analyze a unique interview-based design in which multiple medical providers independently generate problem lists for each of three patient case abstracts of varying clinical difficulty. Due to the uniqueness of both our data and the scientific objectives of our analysis, we apply and extend so-called multistage models for ordered lists and equip the models with variable selection penalties to induce sparsity. Each problem has a corresponding non-negative parameter estimate, interpreted as a relative log-odds ratio, with larger values suggesting greater importance and zero values suggesting unimportant problems. We use these fitted penalized models to quantify and report the extent of consensus. For the three case abstracts, the proportions of problems with model-estimated non-zero log-odds ratios were 10/28, 16/47, and 13/30. Physicians exhibited consensus on the highest ranked problems in the first and last case abstracts but agreement quickly deteriorates; in contrast, physicians broadly disagreed on the relevant problems for the middle and most difficult case abstract