Crystalline Salt Formation of an Acidic Drug Indomethacin Using Hot Melt Extrusion Technology

Although salt formation is the most ubiquitous and effective method of increasing the solubility and dissolution rates of acidic and basic drugs, it consumes large quantities of organic solvents and is a batch process. Herein, we show that the dissolution rate of indomethacin (a poorly water-soluble drug) can be increased by using hot melt extrusion of a 1:1 (mol/mol) indomethacin:tromethamine mixture to form a highly crystalline salt, the physicochemical properties of which are investigated in detail. Specifically, pH–solubility studies demonstrated that this salt exhibited a maximal solubility of 19.34 mg/mL (\u3e1000 times that of pure indomethacin) at pH 8.19. A solvent evaporation technique was also used for salt formation. Spectroscopic analyses (infrared, nuclear magnetic resonance) of both methods; demonstrated, in situ salt formation with proton transfer. Powder X-ray diffraction and differential scanning calorimetry confirmed the crystalline nature of salts formed in both methods. Even though a number of amorphous salts of acidic drugs have been reported, the formation of a crystalline salt of an acidic drug by hot melt extrusion is completely unprecedented, which makes this study an important benchmark for the pharmaceutical production industry

Adult Attachment and Relationship Status (Single vs. Partnered) in Polish Young Adults

This study examined links between adult attachment and relationship status (single vs. partnered) in Polish young adults. Three hundred and seventeen participants (173 females and 144 males) aged 22-27 years old (M = 24.69, SD = 1.87), completed the Polish-language version of the Revised Adult Attachment Scale (RAAS) used to measure adult attachment. All the respondents were heterosexual, unmarried and had no children. One hundred and fifty seven (49.50%) students declared being in a romantic relationship at the time of the assessment whilst 160 students (50.50%) were not. Results indicated that single participants reported higher levels of worry about being rejected or unloved (Anxiety dimension) and lower levels of comfort with closeness (Close dimension), and comfort with depending on others (Depend dimension). In terms of attachment categories, analyses indicated that higher proportions of single participants were categorized into fearful and preoccupied attachment styles and a lower proportion of them were categorized into the secure attachment style compared to partnered individuals. Discriminant analysis revealed that worry of being rejected or unloved (Anxiety dimension) was the strongest factor discriminating between single and partnered relationship status: the higher the anxiety dimension scores, the higher chances of being single. No gender differences were obtained on attachment dimensions and styles.</p

Reflections from Pioneering Women in Psychology

This volume traces the life journeys of a cohort of influential and transformative women in psychology, now in or nearing retirement, who have changed the discipline and the broader world of academia in significant ways. The 26 reflective essays record how these scholars thrived in an academic landscape that was often, at best, unwelcoming, and, at worst, hostile, toward them. They explicitly and implicitly acknowledge that their paths were inextricably linked with the evolution of women\u27s roles in society; they highlight and celebrate their achievements as much as they acknowledge and recognize the obstacles, barriers, and hurdles they overcame. They tell their stories with candor and humor, resulting in a compilation of inspiring essays. The end result of these individual narratives is a volume that provides a unique resource for current and future academics to help them navigate through the crossroads, curves, and challenges of their own careers in academia.https://cupola.gettysburg.edu/books/1188/thumbnail.jp

The Influence of Food Recommendations: Evidence from a Randomized Field Experiment

We report results from a randomized field experiment conducted at two food festivals. Our primary aim is to assess the impact of two types of recommendations commonly observed in food settings: most popular and chef’s choice. Subjects select a cupcake from a binary menu. The two options, offered by the same bakery, are the best seller in the bakery and the baker’s recommended cupcake. Our treatments manipulate whether the recommendation is disclosed in tandem with the cupcakes in the menu. We find that the most popular is the only recommendation that statistically significantly increased consumers’ demand relative to a baseline without recommendations. Furthermore, we find that this effect only holds for subjects from outside the local region. Our results are consistent with laboratory studies indicating information on peers’ choices is a powerful influence on consumers’ decisions, especially in the absence of prior knowledge

Racial/Ethnic Preferences, Sex Preferences, and Perceived Discrimination Related to End-of-Life Care

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65453/1/j.1532-5415.2005.00526.x.pd

The Neuroscience of Positive Emotions and Affect:Implications for Cultivating Happiness and Wellbeing

This review paper provides an integrative account regarding neurophysiological correlates of positive emotions and affect that cumulatively contribute to the scaffolding for happiness and wellbeing in humans and other animals. This paper reviews the associations among neurotransmitters, hormones, brain networks, and cognitive functions in the context of positive emotions and affect. Consideration of lifespan developmental perspectives are incorporated, and we also examine the impact of healthy social relationships and environmental contexts on the modulation of positive emotions and affect. The neurophysiological processes that implement positive emotions are dynamic and modifiable, and meditative practices as well as flow states that change patterns of brain function and ultimately support wellbeing are also discussed. This review is part of "The Human Affectome Project" (http://neuroqualia.org/background.php), and in order to advance a primary aim of the Human Affectome Project, we also reviewed relevant linguistic dimensions and terminology that characterizes positive emotions and wellbeing. These linguistic dimensions are discussed within the context of the neuroscience literature with the overarching goal of generating novel recommendations for advancing neuroscience research on positive emotions and wellbeing

The impact of relationship quality on life satisfaction and well-being in dementia caregiving dyads: findings from the IDEAL study

Objectives: The quality of the relationship between people with dementia and their informal caregiver maybe an important determinant of life satisfaction and well-being for both members of the dyad. Taking a dyadic perspective, the aim of this study was to examine whether self- and partner-rated relationship quality influences life satisfaction and well-being for both people with dementia and their caregivers. Design and methods: Using data from 1283 dyads in the Improving the Experience of Dementia and Enhancing Active Life (IDEAL) cohort, we examined the impact of current relationship quality on life satisfaction and well-being in dementia caregiving dyads. Data were analysed using the Actor–Partner Interdependence Model (APIM) framework. Results: Self-rated relationship quality was associated with own life satisfaction and well-being for both people with dementia and caregivers. Partner-rated relationship quality did not influence own life satisfaction or well-being for either member of the dyad. Conclusion: This study is the first to use the APIM framework to explore the dyadic associations between relationship quality and life satisfaction and well-being in a large cohort of dementia caregiving dyads. The obtained findings suggest that the individual perception of the quality of the caregiving relationship held by each member of the caregiving dyad is an important factor for that member’s life satisfaction and well-being, while the partner’s perception of relationship quality is not. The findings highlight the importance of considering the individual perspective of both the person with dementia and the caregiver and enabling each to maintain positive perceptions of relationship quality

The impact of positive psychological interventions on well-being in healthy elderly people

This systematic review aims to evaluate the impact of Positive Psychological Interventions (PPIs) on well-being in healthy older adults. Systematic review of PPIs obtained from three electronic databases (PsycINFO, Scopus, and Web of Science) was undertaken. Inclusion criteria were: that they were positive psychology intervention, included measurement of well-being, participants were aged over 60 years, and the studies were in English. The Cochrane Collaboration Guidelines dimensions of quality control, randomization, comparability, follow-up rate, dropout, blinding assessors are used to rate the quality of studies by two reviewers independently. The RE-AIM (Reach, Efficacy, Adoption, Implementation, and Maintenance) for evaluation of PPIs effectiveness was also applied. The final review included eight articles, each describing a positive psychological intervention study. The reminiscence interventions were the most prevalent type of PPIs to promote and maintain well-being in later life. Only two studies were rated as high quality, four were of moderate-quality and two were of low-quality. Overall results indicated that efficacy criteria (89%), reach criteria (85%), adoption criteria (73%), implementation criteria (67%), and maintenance criteria (4%) across a variety of RE-AIM dimensions. Directions for future positive psychological research related to RE-AIM, and implications for decision-making, are described