Estimation of User's Orientation via Wearable UWB

User's orientation in indoor environments is an important part of her context. Orientation can be useful to understand what the user is looking at, and thus to improve the interaction between her and the surrounding environment. In this paper, we present a method based on wearable UWB-enabled devices. The position of the devices in space is used to estimate the user's orientation. We experimentally evaluated the impact of some operational parameters, such as the distance between worn devices, or some environmental conditions, such as the position of the user in the room. Results show that the accuracy of the method suits the needs of a wide range of practical purposes

Handwriting in primary school: comparing standardized tests and evaluating impact of grapho-motor parameters

A growing number of primary school students experience difficulties with grapho-motor skills involved in handwriting, which impact both form and content of their texts. Therefore, it is important to assess and monitor handwriting skills in primary school via standardized tests and detect specific grapho-motor parameters (GMPs) which impact handwriting legibility. Multiple standardized tools are available to assess grapho-motor skills in primary school, yet little is known on between-test agreement, on impact of specific GMPs on children's overall performance and on which GMPs may be specifically hard to tackle for children that are starting to consolidate their handwriting skills. These data would be extremely relevant for clinicians, therapists and educators, who have to choose among different assessment tools as well as design tailored intervention strategies to reach adequate performance on different GMPs in cases of poor handwriting. To gain better understanding of currently available standardized tools, we compared overall performance of 39 Italian primary school children (19 second graders and 20 third graders) experiencing difficulties with handwriting on three standardized tests for grapho-motor skills assessment and explored the impact of individual GMPs on child performance. Results showed some agreement between tests considering all children in our sample, but no agreement in second grade and only limited agreement in third grade. Data also allowed highlighting significant correlations between some GMP scores and children's overall performance in our sample. Finally, children in our sample appeared to experience specific difficulties with some GMPs, such as letter joins and alignment

Excited states in Sm139 described with the interacting boson model plus broken pairs

The high-spin structure of Sm139 has been studied through the Pd110(34S,5n) reaction at beam energies of 150 and 165 MeV. The level scheme has been extended up to an excitation energy of 11.1 MeV and spin 61/2+. A band built on the νi13/2 [660]1/2+ intruder orbital has been established and firmly linked to the known lower-spin levels in the nucleus. The low-lying states of both parities as well as a relatively strong ΔI=1 regular structure observed above spin 27/2- are nicely reproduced by the interacting boson-fermion model with broken pairs

Broken pairs and evolution of collectivity in the A≊140 mass region: High spin states of the ^138_60Nd_78 nucleus

An in-beam γ-ray study performed with the 121Sb(19F,4n) reaction has established the high spin level structure of the N=78 nucleus 138Nd. States up to I=21ħ and 8.5 MeV excitation energy have been indentified. High spin states are described in the framework of the cranking model and of the interacting boson model with broken pairs. The calculations reproduce levels up to I=18ħ including the two 10+ states which, from the feeding cascades, are identified as the νh^-1_11/2 and πh^2_11/2 excitations. Cranked Strutinsky type calculations predict opposite shapes for the two different types of excitations

Lifetime measurements of high-spin states in Ag-101 and their interpretation in the interacting boson fermion plus broken pair model

Lifetimes of 20 high spin states in Ag-101 in the range between 0.2 and 200 ps have been measuredand interpreted within the boson fermion plus broken pair model

Self-reported pediatricians' management of the well-appearing young child with fever without a source: first survey in an European country in the anti-pneumococcal vaccine era

<p>Abstract</p> <p>Background</p> <p>Recent studies suggest a substantially reduced risk of invasive bacterial infection in children vaccinated with heptavalent pneumococcal conjugate vaccine (PCV). To investigate whether the introduction of PCV might affect clinical decision making, we conducted a cross-sectional survey aimed at Italian Pediatric physicians.</p> <p>Results</p> <p>The study included 348 (46.5%) primary care pediatricians; 251 (36.4%) hospital pediatricians, and 139 (20.1%) pediatric residents. In an hypothetical scenario, a well-appearing 12-month-old child with fever without source would be sent home with no therapy by 60.7% (419/690) of physicians if the child was not vaccinated with PCV. The proportion increased to 74.2% (512/690) if the child had received PCV (P < 0.0001). Also, physicians would obtain blood tests less frequently in the vaccinated than in unvaccinated children (139/690 [20.1%] <it>vs</it>. 205/690 [29.7%]; P < 0.0001), and started empiric antibiotic therapy less frequently (3.0% <it>vs</it>. 7.5%; P < 0.0001). In the hypothetical event that white blood cell count was 17,500/μL, a significantly lower proportion of physicians would ask for erythrocyte sedimentation rate (P < 0.017), C reactive protein (P < 0.0001), blood culture (P = 0.022), and urine analysis or dipstick (P = 0.028), if the child had received PCV. Only one third of participants routinely recommended PCV.</p> <p>Conclusion</p> <p>Our data suggest that implementation of educational programs regarding the proper management of the febrile child is needed.</p

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage (“DH270”), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man9-V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs—the conserved GDIR motif and the N332 glycan. In our structure of an antibody fragment of a lineage member, DH270.6, in complex with the V3 glycopeptide, the conformation of the antibody-bound glycopeptide conforms closely to that of the corresponding segment in an intact HIV-1 Env trimer. An additional structure identifies roles for two critical mutations in the development of breadth. The results suggest a strategy for use of a V3 glycopeptide as a vaccine immunogen

Varicella: epidemiological aspects and vaccination coverage in the Veneto Region

<p>Abstract</p> <p>Background</p> <p>With the control of many infections through national vaccination programmes, varicella is currently the most widespread preventable childhood disease in industrialized nations. In 2005 varicella vaccination was added to the Veneto Region routine immunization schedule for all children at 14 months of age and 12 year-old susceptible adolescents through an active and a free of charge offer. To evaluate parameters at the start of the programme, we conducted a study to describe the epidemiology of varicella infection and coverage rates for varicella vaccine in the Veneto Region (North-East Italy).</p> <p>Methods</p> <p>We examined incidence rates and median age of case patients in the Veneto Region for 2000-2007 period using two data sources: the mandatory notification of infections diseases and the Italian Paediatric Sentinel Surveillance System of Vaccine Preventable Diseases. Corrected coverage rates were calculated from data supplied by the Public Health and Screening Section of the Regional Department for Prevention.</p> <p>Results</p> <p>In the Veneto Region from 2000 to 2007, a total of 99,351 varicella cases were reported through mandatory notifications, mostly in children under 15 years of age. The overall standardised annual incidence ranged from 2.0 to 3.3 per 1,000 population, with fluctuations from year to year. The analysis by geographic area showed a similar monthly incidence rate in Italy and in the Veneto Region. The vaccination average adherence rate was 8.2% in 2004 cohort, 63.5% in 2005 cohort and 86.5% in 2006 cohort. Corrected coverage rates were 8.1% in 2004 cohort, 59.9% in 2005 cohort and 70.0% in 2006 cohort, respectively.</p> <p>Conclusion</p> <p>Data from passive and active surveillance systems confirm that varicella is a common disease which each year affects a large proportion of the population, mainly children. Uptake of the varicella vaccination programme was strikingly good with average coverage rates of about 70% after only 3 years. Sustained implementation of existing vaccine policies is needed to warrant any significant reduction of varicella incidence in the Veneto Region. Continued surveillance will be important to monitor the impact of the recently introduced mass vaccination policy.</p

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

A preventive HIV-1 vaccine should induce HIV-1–specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site adjacent to the third variable loop (V3) of the HIV-1 envelope protein require limited SHM, the V3-glycan epitope is an attractive vaccine target. By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, we identify key events in the ontogeny of a V3-glycan bnAb. Two autologous neutralizing antibody lineages selected for virus escape mutations and consequently allowed initiation and affinity maturation of a V3-glycan bnAb lineage. The nucleotide substitution required to initiate the bnAb lineage occurred at a low-probability site for activation-induced cytidine deaminase activity. Cooperation of B cell lineages and an improbable mutation critical for bnAb activity defined the necessary events leading to breadth in this V3-glycan bnAb lineage. These findings may, in part, explain why initiation of V3-glycan bnAbs is rare, and suggest an immunization strategy for inducing similar V3-glycan bnAbs