Screening of wood/forest and vine by-products as sources of new drugs for sustainable strategies to control fusarium graminearum and the production of mycotoxins

Fusarium graminearum is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by F. graminearum. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by F. graminearum. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling F. graminearum and its production of mycotoxins.Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovatio

Modélisation, optimisation, développement, évaluation de la chimiothérapie par docétaxel-épirubicine dans le cancer du sein métastatique (Protocole MODEL-1 (étude pilote de phase 1))

LYON1-BU Santé (693882101) / SudocSudocFranceF

Consommation durable et sécurité alimentaire

Bonnin-De Toffoli Coralie, Lazaric Nathalie. Consommation durable et sécurité alimentaire. In: Revue Juridique de l'Environnement, n°4, 2013. pp. 625-635

Consommation durable et sécurité alimentaire

Bonnin-De Toffoli Coralie, Lazaric Nathalie. Consommation durable et sécurité alimentaire. In: Revue Juridique de l'Environnement, n°4, 2013. pp. 625-635

Intravenous Administration of Human Adipose Derived-Mesenchymal Stem Cells Is Not Efficient in Diabetic or Hypertensive Mice Subjected to Focal Cerebral Ischemia

Copyright © 2019 Mangin, Cogo, Moisan, Bonnin, Maïer and Kubis.As the second cause of death and cognitive decline in industrialized countries, stroke is a major burden for society. Vascular risks factors such as hypertension and diabetes are involved in most stroke patients, aggravate stroke severity, but are still poorly taken into account in preclinical studies. Microangiopathy and sustained inflammation are exacerbated, likely explaining the severity of stroke in those patients. We sought to demonstrate that intravenous administration of human adipose derived-mesenchymal stem cells (hADMSC) that have immunomodulatory properties, could accelerate sensorimotor recovery, prevent long-term spatial memory impairment and promote neurogenesis, in diabetic or hypertensive mice, subjected to permanent middle cerebral artery occlusion (pMCAo). Diabetic (streptozotocin IP) or hypertensive (L-NAME in drinking water) male C57Bl6 mice subjected to pMCAo, were treated by hADMSC (500,000 cells IV) 2 days after cerebral ischemia induction. Infarct volume, neurogenesis, microglial/macrophage density, T-lymphocytes density, astrocytes density, and vessel density were monitored 7 days after cells injection and at 6 weeks. Neurological sensorimotor deficit and spatial memory were assessed until 6 weeks post-stroke. Whatever the vascular risk factor, hADMSC showed no effect on functional sensorimotor recovery or cognitive decline prevention at short or long-term assessment, nor significantly modified neurogenesis, microglial/macrophage, T-lymphocytes, astrocytes, and vessel density. This work is part of a European program (H2020, RESSTORE). We discuss the discrepancy of our results with those obtained in rats and the optimal cell injection time frame, source and type of cells according to the species stroke model. A comprehensive understanding of the mechanisms preventing recovery should help for successful clinical translation, but first could allow identifying good and bad responders to cell therapy in stroke.The RESSTORE project received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Grant Agreement No. 681044 RESSTORE project (www.resstore.eu) and GM was directly funded by the RESSTORE project

Assessing climate change impacts on marine ecosystems and human activities in the Arctic ocean: the european ACCESS programme (2011-2015)

International audienc

Rapid Differentiation of Experimental Populations of Wheat for Heading Time in Response to Local Climatic Conditions

• Background and Aims Dynamic management (DM) of genetic resources aims at maintaining genetic variability between different populations evolving under natural selection in contrasting environments. In 1984, this strategy was applied in a pilot experiment on wheat (Triticum aestivum). Spatio-temporal evolution of earliness and its components (partial vernalization sensitivity, daylength sensitivity and earliness per se that determines flowering time independently of environmental stimuli) was investigated in this multisite and long-term experiment