Estudio multidisciplinario e interinstitucional de dos fuentes principales de agua potable para la Provincia de Córdoba

Las fuentes de aguas superficiales son eje de desarrollo de los seres humanos, ya que permiten el abastecimiento para diferentes actividades socioeconómicas. No obstante, de forma paradójica, muchas de estas actividades causan alteración y deterioro de las mismas. Con el fin de contribuir al fortalecimiento de la articulación entre el estado, la sociedad y la Universidad desde hace aproximadamente dos décadas un equipo conformado por docentes investigadores, ayudantes de investigación, profesionales y personal técnico realizan un estudio multidisciplinar e interinstitucional en cuerpos de agua superficiales de la provincia de Córdoba. Los mayores esfuerzos están enfocados hacia dos fuentes principales de agua potable de la provincia: El río Tercero (Ctalamochita) -como parte de la cuenca del río Carcarañá- y el embalse Los Molinos. Dado que el agua propicia el bienestar de la población y el crecimiento inclusivo, y tiene un impacto positivo en la vida de las personas, al incidir en aspectos que afectan la seguridad alimentaria y energética, la salud humana y el ambiente; en el presente trabajo se brindan las principales conclusiones y recomendaciones (para diferentes usos) en ambos cuerpos de agua abordando la problemática de calidad y cantidad de agua. Tales recomendaciones aspiran a contribuir al desarrollo de un sistema de gestión integrada de los recursos hídricos con un enfoque participativo para asegurar la sostenibilidad de los ecosistemas involucrados.Fil: Bazan, Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: García, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Díaz Lozada, José Manuel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Estudios Avanzados en Ingeniería y Tecnología. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Estudios Avanzados en Ingeniería y Tecnología; ArgentinaFil: chalimond, María Laura

Estudio multidisciplinario e interinstitucional de dos fuentes principales de agua potable para la Provincia de Córdoba

Las fuentes de aguas superficiales son eje de desarrollo de los seres humanos, ya que permiten el abastecimiento para diferentes actividades socioeconómicas. No obstante, de forma paradójica, muchas de estas actividades causan alteración y deterioro de las mismas. Con el fin de contribuir al fortalecimiento de la articulación entre el estado, la sociedad y la Universidad desde hace aproximadamente dos décadas un equipo conformado por docentes investigadores, ayudantes de investigación, profesionales y personal técnico realizan un estudio multidisciplinar e interinstitucional en cuerpos de agua superficiales de la provincia de Córdoba. Los mayores esfuerzos están enfocados hacia dos fuentes principales de agua potable de la provincia: El río Tercero (Ctalamochita) -como parte de la cuenca del río Carcarañá- y el embalse Los Molinos. Dado que el agua propicia el bienestar de la población y el crecimiento inclusivo, y tiene un impacto positivo en la vida de las personas, al incidir en aspectos que afectan la seguridad alimentaria y energética, la salud humana y el ambiente; en el presente trabajo se brindan las principales conclusiones y recomendaciones (para diferentes usos) en ambos cuerpos de agua abordando la problemática de calidad y cantidad de agua. Tales recomendaciones aspiran a contribuir al desarrollo de un sistema de gestión integrada de los recursos hídricos con un enfoque participativo para asegurar la sostenibilidad de los ecosistemas involucrados

Comment on "Real-World Use of a New Hybrid Closed Loop Improves Glycemic Control in Youth with Type 1 Diabetes" by Messer et al

No abstract availabl

Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR?

Biallelic insulin receptor (INSR) gene mutations cause congenital syndromes of severe insulin resistance (SIR) known as Donohue syndrome (DS) and Rabson–Mendenhall syndrome (RMS). At presentation, DS and RMS are difficult to differentiate since they share many clinical features; however, while patients with DS usually die within 1 year of birth, individuals classified as RMS can reach adult age. INSR mutations can be also found in pubertal females with hyperinsulinism, hyperandrogenism, and acanthosis nigricans (type A SIR). We studied the INSR gene in five subjects with congenital SIR and in a patient with type A SIR. Nine biallelic INSR gene mutations (eight novels, including an in-frame deletion of INSR signal peptide) were identified in patients with congenital SIR; a heterozygous, spontaneous INSR mutation was detected in the patient with type A SIR. Two probands, presenting severe hirsutism at birth, died at the age of 3 months and were classified as DS, while other 2, currently 2 and 3 years old, were diagnosed with RMS (patients 3 and 4). The fifth patient with congenital SIR died when 14 months old. Nephrocalcinosis, hyperaldosteronism, hyperreninemia, and hypokalemia, in the absence of hypertension, were discovered in patients 3 and 5 when 24 and 4 months old, respectively. Patient 3, now 3 years/3 months old, still shows hyperreninemic hyperaldosteronism requiring potassium supplementation. We conclude that renal abnormalities resembling antenatal Bartter’s syndrome type II, recently reported also by others, is a common observation in patients with congenital SIR

Significant and persistent improvements in time in range and positive emotions in children and adolescents with type 1 diabetes using a closed-loop control system after attending a virtual educational camp

Objective To evaluate the six-month impact of the advanced automated functions of a closed-loop control (CLC) system (Control-IQ) and a virtual educational camp (vEC) on emotions and time in range (TIR) of children and adolescents with type 1 diabetes. Methods Children and their parents participated in a three-day vEC. Clinical, glucose, and emotion data were evaluated before, just after, and six months after the vEC. Emotions were evaluated using adapted Plutchik's and Geneva Emotion Wheels. Results Forty-three children and adolescents (7–16 years) showed significant improvements in positive emotions immediately and six months after the vEC (67% and 65% vs 38%, p < 0.05, respectively), while mixed emotions were reduced (32% and 15% vs 61%, p < 0.05 and p < 0.001, respectively). The median percentage TIR increased from 64% (IQR 54–72) to 75% (IQR 70–82) with Control-IQ (p < 0.001) six months after the vEC. Conclusions Positive emotions (joy, serenity, and satisfaction) significantly improved while mixed emotions were significantly worse six months after the initiation of a CLC system (Control-IQ) and a vEC

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: a prospective multicenter real-life study

Aim: Education maximizes the benefits of new diabetes technology. Here we evaluated the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and methods: This was a prospective multicenter study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ\u2122 system. Insulin pumps were upgraded to Control-IQ\u2122, and children and their parents participated in a three-day multidisciplinary vEC. Clinical data, glucose metrics, and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56-73) with Basal-IQ to 76% (IQR 71-81) with Control-IQ (p < 0.001). After the vEC, over 75% of participants achieved TIR >70%. The percentage of time between 180-250 mg/dL and above 250 mg/dL decreased by 5% (p < 0.01) and 6% (p < 0.01), respectively, while the time between 70-54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (p < 0.01). There were no diabetic ketoacidosis or severe hypoglycemia episodes. Conclusions: In this study of children managing their diabetes in the real-world setting, over 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR >70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes

Comment on “Real-World Use of a New Hybrid Closed Loop Improves Glycemic Control in Youth with Type 1 Diabetes” by Messer et al

We read with interest the article by Messer et al.1 reporting a significant increase in time in range (TIR, +9%, P < 0.001) in 191 children and adolescents using a closed-loop control (CLC) system (Tandem t:slim X2 insulin pump with Control-IQ technology, San Diego, CA). This result is noteworthy given the difficulties in achieving good glycemic control, especially in children.2,3 In addition to technology, we believe that education, especially when designed for sharing between pediatric centers, can maximize the benefits of new diabetes technology. To this end, in 2020 and at the same time as CLC with the Control-IQ system was introduced in Italy, we organized a virtual educational camp (vEC) for children and adolescents with type 1 diabetes. The aims, structure, and 3- and 6-month outcomes of the vEC are detailed elsewhere.4,5 In this study, we present the glycemic metrics 9 months after the vEC. Nineteen Italian pediatric diabetes centers participated in this IRB-approved prospective multicenter clinical study.4,5 Children (6–17 years) who had already used the Basal-IQ system for at least 3 months with the carbohydrate counting system and were available to test Control-IQ and share their data on data-syncing software were enrolled and actively participated in the vEC.4 Each patient was then followed up by their own center every 3 months. If needed, teleconsultation and televisits were offered. The main study outcomes are as shown in Table 1. The 43 participants were aged 7–16 years (median 12, interquartile range [IQR] 9–13), of whom 53.5% were female. The duration of diabetes ranged from 2 to 13 years (median 6; IQR 4–9). The median body mass index z-score was −0.2 (IQR −0.6 to 0.2), and 19 (45%) participants were prepubertal according to Tanner's classification