PHYTOCHEMICAL, MICROBIOLOGICAL, AND TECHNOLOGICAL STUDIES IN THE FIELD OF OBTAINING A HYDROALCOHOLIC EXTRACT WITH ANTIMICROBIAL ACTIVITY FROM THE LIQUORICE ROOT

Objective: The objective of this work was to carry out studies in the field of development of a hydroalcoholic extract from the liquorice root that has a high level of antimicrobial activity.Methods: For the antibacterial study of extracts, we have used the agar well diffusion method. In our research, we have utilized six test-strain microorganisms: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Proteus vulgaris ATCC 4636, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653, and Bacillus subtilis ATCC 6633. Authors have applied vector theory for antimicrobial activity comparison of liquorice root extracts.Results: Phytochemical composition and antimicrobial activity of hydroalcoholic extracts from the liquorice root with the use of different concentrations of ethanol have been studied. The optimal range of ethanol concentration of 65±15% v/v has been found. The dependency between the integral index of antimicrobial activity of the extract and concentration of glycyram and licuroside has been found. The minimal concentration of glycyram and licuroside in the extract has been calculated for an exhibition of the target level of extract's antimicrobial activity, which is 1.0 and 0.11% w/v, respectively.Conclusion: It has been found that the concentration of licuroside has greater influence on the integral index of extract's antimicrobial activity in comparison with that one of glycyram. A highly effective technology for obtaining an extract with target phytochemical parameters has been suggested

Synthesis of Optimal Algorithms of Recognition of Group Air Targets in Airborne Radar Systems

В статье при байесовском критерии оптимальности синтезированы алгоритмы распознавания на этапе вторичной обработки сигналов численного и типового состава групповой воздушной цели (ГВЦ), характера её полёта в радиолокационных системах (РЛС) воздушного базирования, построенных по импульсно-доплеровскому (ИД) принципу обработки сигналов с длительным временем их когерентного накопления. При этом предполагается, что имеется информация о состоянии ГВЦ, полученная в результате обработки сигналов в РЛС на этапе первичной обработки радиолокационных (РЛ) сигналов, отражённых от ГВЦ.In the article by Bayesian optimality criteria algorithms for the recognition stage, the secondary signal processing and numerical model of group air targets , the nature of its flight in radar systems , airborne, built by pulse-Doppler (ID) principle of signal processing of a long time coherent accumulation. In this case, it is assumed that there is information about the state of group air targets, the resulting signal processing in radar at the stage of primary processing of radar (radar) signals reflected from the group of air target

ATP synthase FOF1 structure, function, and structure-based drug design

ATP synthases are unique rotatory molecular machines that supply biochemical reactions with adenosine triphosphate (ATP)—the universal “currency”, which cells use for synthesis of vital molecules and sustaining life. ATP synthases of F-type (FOF1) are found embedded in bacterial cellular membrane, in thylakoid membranes of chloroplasts, and in mitochondrial inner membranes in eukaryotes. The main functions of ATP synthases are control of the ATP synthesis and transmembrane potential. Although the key subunits of the enzyme remain highly conserved, subunit composition and structural organization of ATP synthases and their assemblies are significantly different. In addition, there are hypotheses that the enzyme might be involved in the formation of the mitochondrial permeability transition pore and play a role in regulation of the cell death processes. Dysfunctions of this enzyme lead to numerous severe disorders with high fatality levels. In our review, we focus on FOF1-structure-based approach towards development of new therapies by using FOF1 structural features inherited by the representatives of this enzyme family from different taxonomy groups. We analyzed and systematized the most relevant information about the structural organization of FOF1 to discuss how this approach might help in the development of new therapies targeting ATP synthases and design tools for cellular bioenergetics control

Synthesis of Optimal Algorithms of Recognition of Group Air Targets in Airborne Radar Systems

В статье при байесовском критерии оптимальности синтезированы алгоритмы распознавания на этапе вторичной обработки сигналов численного и типового состава групповой воздушной цели (ГВЦ), характера её полёта в радиолокационных системах (РЛС) воздушного базирования, построенных по импульсно-доплеровскому (ИД) принципу обработки сигналов с длительным временем их когерентного накопления. При этом предполагается, что имеется информация о состоянии ГВЦ, полученная в результате обработки сигналов в РЛС на этапе первичной обработки радиолокационных (РЛ) сигналов, отражённых от ГВЦ.In the article by Bayesian optimality criteria algorithms for the recognition stage, the secondary signal processing and numerical model of group air targets , the nature of its flight in radar systems , airborne, built by pulse-Doppler (ID) principle of signal processing of a long time coherent accumulation. In this case, it is assumed that there is information about the state of group air targets, the resulting signal processing in radar at the stage of primary processing of radar (radar) signals reflected from the group of air target

Ultrasonography of the larynx for diagnosis of the vocal folds mobility impairment

Purpose. To study a possibility of performance and diagnostic accuracy of ultrasonography (US) of a larynx in identification of motility disorders of VF (vocal folds) in comparison with the laryngoscope which is traditionally applied for this purpose. Materials and methods. According to the objectives of the study, two patient groups were formed. In first group of patients (n = 466) we studied acceptability of ultrasonografy to discriminate various laryngeal structures. In second group of patient (n = 432) we evaluated the diagnostic accuracy of ultrasonography in point of detection of vocal muscles paresis. Results. Laryngeal structures were available to examination by ultrasound (without taking in account age and sex) in 92.7% of patients. Two patterns have been identified in the course of this part of the study: deterioration of visibility of the vocal folds with increasing patient age and better visibility of the vocal folds in women than in men. According to the comparative analysis, ultrasonography accuracy rate (in those patients who had had clearly visible vocal folds during ultrasonography) did not differ from that during videolaryngoscopy. Conclusion. During the conducted research it was found that the US of the larynx is an effective and perspective method for detection of a paresis of VF with sensitivity and specificity 93,55% and 100% respectively. Among those patients whoapos; VF are available to ultrasound evaluation the accuracy of method is comparable with a videolaryngoscopy and can be used with success in daily work of units of endocrine surgery