1,034 research outputs found
Signal-to-Noise Eigenmode Analysis of the Two-Year COBE Maps
To test a theory of cosmic microwave background fluctuations, it is natural
to expand an anisotropy map in an uncorrelated basis of linear combinations of
pixel amplitudes --- statistically-independent for both the noise and the
signal. These -eigenmodes are indispensible for rapid Bayesian analyses of
anisotropy experiments, applied here to the recently-released two-year COBE
{\it dmr} maps and the {\it firs} map. A 2-parameter model with an overall
band-power and a spectral tilt describes well inflation-based
theories. The band-powers for {\it all} the {\it dmr} + GHz
and {\it firs} 170 GHz maps agree, , and
are largely independent of tilt and degree of (sharp) -filtering. Further,
after optimal -filtering, the {\it dmr} maps reveal the same
tilt-independent large scale features and correlation function. The unfiltered
{\it dmr} + index is ; increasing the
-filtering gives a broad region at (1.0--1.2)0.5, a jump to
(1.4--1.6)0.5, then a drop to 0.8, the higher values clearly seen to be
driven by -power spectrum data points that do not fit single-tilt models.
These indices are nicely compatible with inflation values (0.8--1.2), but
not overwhelmingly so.Comment: submitted to Phys.Rev.Letters, 4 pages, uuencoded compressed
PostScript; also bdmr2.ps.Z, via anonymous ftp to ftp.cita.utoronto.ca, cd to
/pub/dick/yukawa; CITA-94-2
Cosmic microwave background snapshots: pre-WMAP and post-WMAP
Abbreviated: We highlight the remarkable evolution in the CMB power spectrum
over the past few years, and in the cosmological parameters for minimal
inflation models derived from it. Grand unified spectra (GUS) show pre-WMAP
optimal bandpowers are in good agreement with each other and with the one-year
WMAP results, which now dominate the L < 600 bands. GUS are used to determine
calibrations, peak/dip locations and heights, and damping parameters. These CMB
experiments significantly increased the case for accelerated expansion in the
early universe (the inflationary paradigm) and at the current epoch (dark
energy dominance) when they were combined with `prior' probabilities on the
parameters. A minimal inflation parameter set is applied in the same way to the
evolving data. Grid-based and and Monte Carlo Markov Chain methods are shown to
give similar values, highly stable over time and for different prior choices,
with the increasing precision best characterized by decreasing errors on
uncorrelated parameter eigenmodes. After marginalizing over the other cosmic
and experimental variables for a weak+LSS prior, the pre-WMAP data of Jan03 cf.
the post-WMAP data of Mar03 give Omega_{tot} =1.03^{+0.05}_{-0.04} cf.
1.02^{+0.04}_{-0.03}. Adding the flat prior, n_s =0.95^{+0.07}_{-0.04} cf.
0.97^{+0.02}_{-0.02}, with < 2\sigma evidence for a log variation of n_s. The
densities have concordance values. The dark energy pressure-to-density ratio is
not well constrained by our weak+LSS prior, but adding SN1 gives w_Q < -0.7. We
find \sigma_8 = 0.89^{+0.06}_{-0.07} cf. 0.86^{+0.04}_{-0.04}, implying a
sizable SZ effect; the high L power suggest \sigma_8 \sim 0.94^{+0.08}_{-0.16}
is needed to be SZ-compatible.Comment: 36 pages, 5 figures, 5 tables, Jan 2003 Roy Soc Discussion Meeting on
`The search for dark matter and dark energy in the Universe', published PDF
(Oct 15 2003) is http://www.cita.utoronto.ca/~bond/roysoc03/03TA2435.pd
Pharmacist-led management of chronic pain in primary care:results from a randomised controlled exploratory trial
To compare the effectiveness of pharmacist medication review, with or without pharmacist prescribing, with standard care, for patients with chronic pain
Ion currents, action potentials and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes
Heterogeneity of T-Tubules in Pig Hearts
BACKGROUND:T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although t-tubules were generally considered to be effectively absent in atrial myocytes, recent studies on atrial cells from larger mammals suggest that t-tubules may be more numerous than previously supposed. However, the degree of heterogeneity between cardiomyocytes in the extent of the t-tubule network remains unclear. The aim of the present study was to investigate the t-tubule network of pig atrial myocytes in comparison with ventricular tissue. METHODS:Cardiac tissue was obtained from young female Landrace White pigs (45-75 kg, 5-6 months old). Cardiomyocytes were isolated by arterial perfusion with a collagenase-containing solution. Ca2+ transients were examined in field-stimulated isolated cells loaded with fluo-4-AM. Membranes of isolated cells were visualized using di-8-ANEPPS. T-tubules were visualized in fixed-frozen tissue sections stained with Alexa-Fluor 488-conjugated WGA. Binary images were obtained by application of a threshold and t-tubule density (TTD) calculated. A distance mapping approach was used to calculate half-distance to nearest t-tubule (HDTT). RESULTS & CONCLUSION:The spatio-temporal properties of the Ca2+ transient appeared to be consistent with the absence of functional t-tubules in isolated atrial myocytes. However, t-tubules could be identified in a sub-population of atrial cells in frozen sections. While all ventricular myocytes had TTD >3% (mean TTD = 6.94±0.395%, n = 24), this was true of just 5/22 atrial cells. Mean atrial TTD (2.35±0.457%, n = 22) was lower than ventricular TTD (P3% (1.65±0.06 μm, n = 5, P<0.05). These data demonstrate considerable heterogeneity between pig cardiomyocytes in the extent of t-tubule network, which correlated with cell size
Comment on On Sharp Spectral Lines in the Climate Record and the Millennial Peak By Carl Wunsch
Computing CMB Anisotropy in Compact Hyperbolic Spaces
The measurements of CMB anisotropy have opened up a window for probing the
global topology of the universe on length scales comparable to and beyond the
Hubble radius. For compact topologies, the two main effects on the CMB are: (1)
the breaking of statistical isotropy in characteristic patterns determined by
the photon geodesic structure of the manifold and (2) an infrared cutoff in the
power spectrum of perturbations imposed by the finite spatial extent. We
present a completely general scheme using the regularized method of images for
calculating CMB anisotropy in models with nontrivial topology, and apply it to
the computationally challenging compact hyperbolic topologies. This new
technique eliminates the need for the difficult task of spatial eigenmode
decomposition on these spaces. We estimate a Bayesian probability for a
selection of models by confronting the theoretical pixel-pixel temperature
correlation function with the COBE-DMR data. Our results demonstrate that
strong constraints on compactness arise: if the universe is small compared to
the `horizon' size, correlations appear in the maps that are irreconcilable
with the observations. If the universe is of comparable size, the likelihood
function is very dependent upon orientation of the manifold wrt the sky. While
most orientations may be strongly ruled out, it sometimes happens that for a
specific orientation the predicted correlation patterns are preferred over the
conventional infinite models.Comment: 15 pages, LaTeX (IOP style included), 3 color figures (GIF) in
separate files. Minor revision to match the version accepted in Class.
Quantum Grav.: Proc. of Topology and Cosmology, Cleveland, 1997. The paper
can be also downloaded from
http://www.cita.utoronto.ca/~pogosyan/cwru_proc.ps.g
ACCOMMODATING MIXED-SEVERITY FIRE TO RESTORE AND MAINTAIN ECOSYSTEM INTEGRITY WITH A FOCUS ON THE SIERRA NEVADA OF CALIFORNIA, USA
Existing fire policy encourages the maintenance of ecosystem integrity in fire management, yet this is difficult to implement on lands managed for competing economic, human safety, and air quality concerns. We discuss a fire management approach in the mid-elevations of the Sierra Nevada, California, USA, that may exemplify similar challenges in other fire-adapted regions of the western USA. We also discuss how managing for pyrodiversity through mixed-severity fires can promote ecosystem integrity in Sierran mixed conifer and ponderosa pine (Pinus ponderosa Laws) forests. To illustrate, we show how coarse-filter (landscape-level) and complementary fine-filter (species-level) approaches can enhance forest management and conservation biology objectives as related to wildfire management. At the coarse-filter level, pyrodiverse mixed-severity fires provide landscape heterogeneity. Species and ecosystem characteristics associated with pyrodiversity can be maintained or enhanced by accommodating moderately severe fires, which hasten restoration by recreating a complex vegetation mosaic otherwise at risk from suppression. At the fine-filter level, managers can select focal species and species of conservation concern based on the degree to which those species depend on fire and accommodate their specific conservation needs. The black-backed woodpecker (Picoides arcticus [Swainson, 1832]) is an ideal focal species for monitoring the ecological integrity of forests restored through mixed-severity fire, and the California spotted owl (Strix occidentalis occidentalis [Xantus de Vesey, 1860]) is a species of conservation concern that uses post-fire habitat mosaics and is particularly vulnerable to logging. We suggest a comprehensive approach that integrates wildland fire for ecosystem integrity and species viability with strategic deployment of fire suppression and ecologically based restoration of pyrodiverse landscapes. Our approach would accomplish fire management goals while simultaneously maintaining biodiversity
CMB observations from the CBI and VSA: A comparison of coincident maps and parameter estimation methods
We present coincident observations of the Cosmic Microwave Background (CMB)
from the Very Small Array (VSA) and Cosmic Background Imager (CBI) telescopes.
The consistency of the full datasets is tested in the map plane and the Fourier
plane, prior to the usual compression of CMB data into flat bandpowers. Of the
three mosaics observed by each group, two are found to be in excellent
agreement. In the third mosaic, there is a 2 sigma discrepancy between the
correlation of the data and the level expected from Monte Carlo simulations.
This is shown to be consistent with increased phase calibration errors on VSA
data during summer observations. We also consider the parameter estimation
method of each group. The key difference is the use of the variance window
function in place of the bandpower window function, an approximation used by
the VSA group. A re-evaluation of the VSA parameter estimates, using bandpower
windows, shows that the two methods yield consistent results.Comment: 10 pages, 6 figures. Final version. Accepted for publication in MNRA
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