NASTRAN computer resource management for the matrix decomposition modules

Detailed computer resource measurements of the NASTRAN matrix decomposition spill logic were made using a software input/output monitor. These measurements showed that, in general, job cost can be reduced by avoiding spill. The results indicated that job cost can be minimized by using dynamic memory management. A prototype memory management system is being implemented and evaluated for the CDC Cyber computer

An algorithm for selecting a radiation transport subgrid for ablation and radiation coupled hypersonic viscous shock-layer problems

An algorithm is described for selecting a grid subset for calculating radiative transport. The subset spacing is determined by using the variation in aerothermal properties across the full grid of the shock layer. Results show that a radiation grid subset of 15 to 20 points can be used for viscous-shock layer calculations where approximately 50 grid points are required to define the aerothermal profiles. Results are presented for various planetary entry conditions with and without mass injection to demonstrate both the validity and utility of the algorithm

pi-/pi+ ratio in heavy ions collisions: Coulomb effect or chemical equilibration?

We calculate the pi-/pi+ ratio for Pb+Pb at CERN/SPS energies and for Au+Au at BNL/AGS energies using a (3+1) dimensional hydrodynamical model. Without consideration of Coulomb effect an enhancement of this ratio at low mt is found compatible with that observed in these experiments. Our calculations are based on previous (3+1) dimensional hydrodynamical simulations (HYLANDER), which described many other aspects of experimental data. In this model the observed enhancement is a consequence of baryon and strangeness conservation and of chemical equilibration of the system and is caused by the decay of produced hyperons, which leads to a difference in the total number of positive and negative pions as well. Based on the same approach, we also present results for the pi-/pi+ ratio for S+S (CERN/SPS) collisions, where we find a similar effect. The absence of the enhancement of the pi-/pi+ ratio in the S+S data presented by the NA44 Collaboration, if confirmed, could indicate that chemical equilibration has not yet been estabilished in this reaction.Comment: 8 pages and 2 figures, submmited to Phys. Lett. B. This reviewed version (Nov.29,1996) contains more details about the model simulated efficiency considering the experimental detection conditions. Other small modifications were mad

Use of recombinant virus replicon particles for vaccination against Mycobacterium ulcerans disease

Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries. The majority of clinical presentations seen in patients are ulcers on limbs that can be treated by eight weeks of antibiotic therapy. Nevertheless, scarring and permanent disabilities occur frequently and Buruli ulcer still causes high morbidity. A vaccine against the disease is so far not available but would be of great benefit if used for prophylaxis as well as therapy. In the present study, vesicular stomatitis virus-based RNA replicon particles encoding the M. ulcerans proteins MUL2232 and MUL3720 were generated and the expression of the recombinant antigens characterized in vitro. Immunisation of mice with the recombinant replicon particles elicited antibodies that reacted with the endogenous antigens of M. ulcerans cells. A prime-boost immunization regimen with MUL2232-recombinant replicon particles and recombinant MUL2232 protein induced a strong immune response but only slightly reduced bacterial multiplication in a mouse model of M. ulcerans infection. We conclude that a monovalent vaccine based on the MUL2232 antigen will probably not sufficiently control M. ulcerans infection in humans