True to oneself? Broad and narrow ideas on authenticity in the enhancement debate

Our knowledge of the human brain and the influence of pharmacological substances on human mental functioning is expanding. This creates new possibilities to enhance personality and character traits. Psychopharmacological enhancers, as well as other enhancement technologies, raise moral questions concerning the boundary between clinical therapy and enhancement, risks and safety, coercion and justice. Other moral questions include the meaning and value of identity and authenticity, the role of happiness for a good life, or the perceived threats to humanity. Identity and authenticity are central in the debate on psychopharmacological enhancers. In this paper, I first describe the concerns at issue here as extensively propounded by Carl Elliott. Next, I address David DeGrazia’s theory, which holds that there are no fundamental identity-related and authenticity-related arguments against enhancement technologies. I argue, however, that DeGrazia’s line of reasoning does not succeed in settling these concerns. His conception of identity does not seem able to account for the importance we attach to personal identity in␣cases where personal identity is changed through enhancement technology. Moreover, his conception of authenticity does not explain the reason why we find inauthentic values objectionable. A broader approach to authenticity can make sense of concerns about changes in personal identity by means of enhancement technologies

Creation and study of formulations as inhibitors of metal corrosion and scaling for stabilization water treatment in water utilization systems (a review)

This review summarizes studies for the past 5 years aimed at creation of efficient organophosphonate reagents for the stabilization water treatment aimed at preventing metal corrosion and scaling in water utilization systems.This study was carried out with state financial support provided by the Russian Ministry of Education and Science under Subsidy Grant Agreement No. 14.576.21.0017 of August 23, 2014

Deep Excavation Braced by Diaphragm Wall in Gdańsk (Poland)

Protection of deep excavation by cast in situ concrete diaphragm walls for Shopping Center in Gdansk (Poland) is described. The structure was designed as five-storey-building with three additional underground floors and founded on diaphragm walls. The excavation was made by “half-floor” method with temporary supports of floor in the form of steel columns. Static calculations of excavation bracing were carried out by PLAXIS numerical code for both design stage (for two calculation schemes: anchored and supported by floor ring) as well as after its construction (back analysis). The calculations served for an assessment of predicted wall displacements, deformations of soil surface around the excavation and internal forces in subsequent stages of the excavation deepening and for different working schemes (supports) of the construction. During construction works vertical displacements of the soil surface around the excavation and surrounding buildings as well as horizontal displacements of diaphragm walls were monitored and compared with the results of corresponding calculations. Some exemplary distributions of calculated and measured values of the wall and soil surface deformations are presented. Subsoil unloading effects and the range of impact zones on the vicinity are also analyzed

The relationship of individual comorbid chronic conditions to diabetes care quality.

ObjectiveMultimorbidity affects 26 million persons with diabetes, and care for comorbid chronic conditions may impact diabetes care quality. The aim of this study was to determine which chronic conditions were related to lack of achievement or achievement of diabetes care quality goals to determine potential targets for future interventions.Research design and methodsThis is an exploratory retrospective analysis of electronic health record data for 23 430 adults, aged 18-75, with diabetes who were seen at seven Midwestern US health systems. The main outcome measures were achievement of six diabetes quality metrics in the reporting year, 2011 (glycated haemoglobin (HbA1c) control and testing, low-density lipoprotein control and testing, blood pressure control, kidney testing). Explanatory variables were 62 chronic condition indicators. Analyses were adjusted for baseline patient sociodemographic and healthcare utilization factors.ResultsThe 62 chronic conditions varied in their relationships to diabetes care goal achievement for specific care goals. Congestive heart failure was related to lack of achievement of cholesterol management goals. Obesity was related to lack of HbA1c and BP control. Mental health conditions were related to both lack of achievement and achievement of different care goals. Three conditions were related to lack of cholesterol testing, including congestive heart failure and substance-use disorders. Of 17 conditions related to achieving control goals, 16 were related to achieving HbA1c control. One-half of the comorbid conditions did not predict diabetes care quality.ConclusionsFuture interventions could target patients at risk for not achieving diabetes care for specific care goals based on their individual comorbidities

The cosmic X-ray experiment aboard HEAO-1

The HEAO-1 A-2 experiment, designed to study the large scale structure of the galaxy and the universe at X-ray energies is described. The instrument consists of six gas proportional counters of three types nominally covering the energy ranges of 0.15-3 keV, 1.2-20 keV, and 2.5-60 keV. The two low energy detectors have about 400 sq cm open area each while the four others have about 800 sq cm each. Dual field of view collimators allow the unambiguous determination of instrument internal background and diffuse X-ray brightness. Instrument characteristics and early performance are discussed

The Intergenerational Elasticity of Earnings: Exploring the Mechanisms

Using data covering a single cohort's first 55 years of life, we show that most of the intergenerational elasticity of earnings (IGE) is explained by differences in: years of schooling, cognitive skills, investments of parental time and school quality, and family circumstances during childhood. To decompose the fraction of the IGE explained by each of these channels, we implement a multi-level mediation analysis combined with a latent factor framework that accounts for measurement error. Multilevel mediation analysis allows us to assess not only the direct effect of each channel on the IGE, but also its indirect effects working through the other channels, thus providing an in-depth understanding of the link between parents' and children's earnings. Of these channels, we show that the main driver of the IGE is increased levels of parental investments received by children of high income parents early in their lives, which encourages greater cognitive development and lifetime earnings

Practice Patterns Of Clinicians: Assessment Of Malnutrition In Ckd Dialysis And Interventions

With limited information on the practice patterns regarding clinician identification of malnutrition and the use of nutritional interventions in malnourished CKD-5 dialysis patients, a market research survey was conducted by NKF sponsored by Pentec Health to evaluate this amongst renal clinicians. For dialysis patients, results for the top four assessment markers were: decreased appetite; albumin level; decrease in dry weight, quality of life. Most commonly recommended oral supplements (OS) were nutritionally complete renal, diabetic and standard products with most common barriers: out of pocket cost; patient resistance; and reimbursement issues. Nutrition support and food during dialysis responses for outpatients in table below:Nutrition Intervention% of clinicians who would recommendBarriers to Use (Top 3 )Tube Feeding28.0 %Not available at unit; patient resistance; family resistanceIntradialytic Parenteral Nutrition (IDPN)48.7 %Reimbursement ; not available at unit; MD resistanceIntraperitoneal Nutrition (IPN)22.0 %Not available at unit; reimbursement; MD resistanceTotal Parenteral Nutrition (TPN)16.9 %Not available at unit; reimbursement, MD resistanceFood During Hemodialysis83.3 % OS 63.3% FoodDrop in blood pressure, risk of aspiration; hygieneFindings: A clinician gap seems to exist around nutrition support interventions in CKD-5 dialysis patients. Meal provision during dialysis could be expanded. These interventions may improve the nutritional status of dialysis patients

Stimulatory effects of antiandrogens on LNCaP human prostate tumor cell growth, EGF-receptor level and acid phosphatase secretion

Abstract LNCaP cells (derived from a lymph node carcinoma of the human prostate) show androgen responsive growth. Progestagens, estradiol and antiandrogens competed with androgens for binding to the androgen receptor in the cells to a higher extent than in other androgen-sensitive systems. Optimal growth (3–4 fold increase in DNA content of 6 day cell cultures vs controls) was observed after addition of the synthetic androgen R1881 (0.1 nM). Both steroidal and non-steroidal antiandrogens did not suppress the androgen responsive growth. At a concentration of 10 nM cyproterone acetate or 100 nM RU 23908, growth was even stimulated to an extent comparable to that observed after addition of androgen. Cyproterone acetate and RU 23908 also increased the number of epidermal growth factor receptors expressed at the cell surface to a comparable level as did the androgen. Like androgens, cyproterone acetate, RU 23908 or estradiol stimulated the secretion per cell of prostate specific acid phosphatase in the culture fluid. In conclusion, antiandrogens can exert striking stimulatory effects on the proliferation of LNCaP cells probably due to a defective androgen receptor system. It is discussed that comparable changes in the specificity of the androgen receptor in prostate cancer cells may give these cells an advantage in growth rate and may contribute to development of tumors characterized as hormone independent