604 research outputs found
The White Horse Patrol
Men will always love beauty and a beautiful horse will always arouse the fancy and admiration of horsemen and laymen alike. To them nothing is more awe-inspiring than matched and intelligent horses. Horses skilled in acting are usually found only in the circus, but occasionally an individual will delight in owning and training a trick horse. When a number of such men are brought together by this mutual interest, the arrangement that results may well lead to something unique in that it deals with living creatures by nature of different conformation, temperament, and capability
Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain: Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model
Models of premature brain injury have largely focused on the white matter injury thought to underlie periventricular leukomalacia (PVL). However, with increased survival of very low birth weight infants, injury patterns involving grey matter are now recognized. We aimed to determine how grey matter lesions relate to hypoxic-ischemic- (HI) mediated white matter injury by modifying our rat model of PVL. Following HI, microglial infiltration, astrocytosis, and neuronal and axonal degeneration increased in a region-specific manner dependent on the severity of myelin loss in pericallosal white matter. The spectrum of injury ranged from mild, where diffuse white matter abnormalities were dominant and were associated with mild axonal injury and local microglial activation, to severe HI injury characterized by focal MBP loss, widespread neuronal degeneration, axonal damage, and gliosis throughout the neocortex, caudate putamen, and thalamus. In sum, selective regional white matter loss occurs in the preterm rat concomitantly with a clinically relevant spectrum of grey matter injury. These data demonstrate an interspecies similarity of brain injury patterns and further substantiates the reliable use of this model for the study of preterm brain injury
Communication: X-ray coherent diffractive imaging by immersion in nanodroplets
Citation: Tanyag, R. M. P., Bernando, C., Jones, C. F., Bacellar, C., Ferguson, K. R., Anielski, D., . . . Vilesov, A. F. (2015). Communication: X-ray coherent diffractive imaging by immersion in nanodroplets. Structural Dynamics, 2(5), 9. doi:10.1063/1.4933297Lensless x-ray microscopy requires the recovery of the phase of the radiation scattered from a specimen. Here, we demonstrate a de novo phase retrieval technique by encapsulating an object in a superfluid helium nanodroplet, which provides both a physical support and an approximate scattering phase for the iterative image reconstruction. The technique is robust, fast-converging, and yields the complex density of the immersed object. Images of xenon clusters embedded in superfluid helium droplets reveal transient configurations of quantum vortices in this fragile system. (C) 2015 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.Additional Authors: Neumark, D. M.;Rolles, D.;Rudek, B.;Rudenko, A.;Siefermann, K. R.;Ullrich, J.;Weise, F.;Bostedt, C.;Gessner, O.;Vilesov, A. F
Imaging Molecular Structure through Femtosecond Photoelectron Diffraction on Aligned and Oriented Gas-Phase Molecules
This paper gives an account of our progress towards performing femtosecond
time-resolved photoelectron diffraction on gas-phase molecules in a pump-probe
setup combining optical lasers and an X-ray Free-Electron Laser. We present
results of two experiments aimed at measuring photoelectron angular
distributions of laser-aligned 1-ethynyl-4-fluorobenzene (C8H5F) and
dissociating, laseraligned 1,4-dibromobenzene (C6H4Br2) molecules and discuss
them in the larger context of photoelectron diffraction on gas-phase molecules.
We also show how the strong nanosecond laser pulse used for adiabatically
laser-aligning the molecules influences the measured electron and ion spectra
and angular distributions, and discuss how this may affect the outcome of
future time-resolved photoelectron diffraction experiments.Comment: 24 pages, 10 figures, Faraday Discussions 17
Coupled motion of Xe clusters and quantum vortices in He nanodroplets
Citation: Jones, C. F., Bernando, C., Tanyag, R. M. P., Bacellar, C., Ferguson, K. R., Gomez, L. F., . . . Vilesov, A. F. (2016). Coupled motion of Xe clusters and quantum vortices in He nanodroplets. Physical Review B - Condensed Matter and Materials Physics, 93(18). doi:10.1103/PhysRevB.93.180510Additional Authors: Erk, B.;Foucar, L.;Hartmann, R.;Neumark, D. M.;Epp, S. W.;Englert, L.;Siefermann, K. R.;Weise, F.;Rudek, B.;Sturm, F. P.;Ullrich, J.;Bostedt, C.;Gessner, O.;Vilesov, A. F.Single He nanodroplets doped with Xe atoms are studied via ultrafast coherent x-ray diffraction imaging. The diffraction images show that rotating He nanodroplets about 200 nm in diameter contain a small number of symmetrically arranged quantum vortices decorated with Xe clusters. Unexpected large distances of the vortices from the droplet center (?0.7-0.8 droplet radii) are explained by a significant contribution of the Xe dopants to the total angular momentum of the droplets and a stabilization of widely spaced vortex configurations by the trapped Xe clusters. © 2016 American Physical Society
Time-Resolved Measurement of Interatomic Coulombic Decay in Ne_2
The lifetime of interatomic Coulombic decay (ICD) [L. S. Cederbaum et al.,
Phys. Rev. Lett. 79, 4778 (1997)] in Ne_2 is determined via an extreme
ultraviolet pump-probe experiment at the Free-Electron Laser in Hamburg. The
pump pulse creates a 2s inner-shell vacancy in one of the two Ne atoms,
whereupon the ionized dimer undergoes ICD resulting in a repulsive
Ne^{+}(2p^{-1}) - Ne^{+}(2p^{-1}) state, which is probed with a second pulse,
removing a further electron. The yield of coincident Ne^{+} - Ne^{2+} pairs is
recorded as a function of the pump-probe delay, allowing us to deduce the ICD
lifetime of the Ne_{2}^{+}(2s^{-1}) state to be (150 +/- 50) fs in agreement
with quantum calculations.Comment: 5 pages, 3 figures, accepted by PRL on July 11th, 201
Micro-CT Based Experimental Liver Imaging Using a Nanoparticulate Contrast Agent: A Longitudinal Study in Mice
BACKGROUND: Micro-CT imaging of liver disease in mice relies on high soft tissue contrast to detect small lesions like liver metastases. Purpose of this study was to characterize the localization and time course of contrast enhancement of a nanoparticular alkaline earth metal-based contrast agent (VISCOVER ExiTron nano) developed for small animal liver CT imaging. METHODOLOGY: ExiTron nano 6000 and ExiTron nano 12000, formulated for liver/spleen imaging and angiography, respectively, were intravenously injected in C57BL/6J-mice. The distribution and time course of contrast enhancement were analysed by repeated micro-CT up to 6 months. Finally, mice developing liver metastases after intrasplenic injection of colon carcinoma cells underwent longitudinal micro-CT imaging after a single injection of ExiTron nano. PRINCIPAL FINDINGS: After a single injection of ExiTron nano the contrast of liver and spleen peaked after 4-8 hours, lasted up to several months and was tolerated well by all mice. In addition, strong contrast enhancement of abdominal and mediastinal lymph nodes and the adrenal glands was observed. Within the first two hours after injection, particularly ExiTron nano 12000 provided pronounced contrast for imaging of vascular structures. ExiTron nano facilitated detection of liver metastases and provided sufficient contrast for longitudinal observation of tumor development over weeks. CONCLUSIONS: The nanoparticulate contrast agents ExiTron nano 6000 and 12000 provide strong contrast of the liver, spleen, lymph nodes and adrenal glands up to weeks, hereby allowing longitudinal monitoring of pathological processes of these organs in small animals, with ExiTron nano 12000 being particularly optimized for angiography due to its very high initial vessel contrast
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Nuclear medicine program progress report for quarter ending September 30, 1996
The reactor production yields of tungsten-188 produced by neutron capture by enriched tungsten-186 in the HFIR and other reactors are nearly an order of magnitude lower than expected by calculation using established cross section values. Since neutron capture of tungsten-188 may be the major factor which significantly reduces the observed yields of tungsten-188, the authors have evaluated the possible burn-up cross section of the tungsten-188 product. Tungsten-189 was produced by irradiating a radioactive target containing a known amount of {sup 188}W. In order to reduce the radiation level to an acceptable level (90% of {sup 188}Re, which is the decay product of {sup 188}W, prior to irradiation. They were able to confirm the two predominant {gamma}-rays in the decay of {sup 189}W, 260.1 {+-} 1.4 and 421.5 {+-} 1.6 keV. By following the decay of these {gamma}-rays in two sets of experiments, a half-life of 10.8 {+-} 0.3 m was obtained for {sup 189}W. Based on a knowledge of the {sup 188}W content of target (52.6 mBq), neutron flux of 5 {times} 10{sup 13} n {center_dot} s{sup {minus}1} {center_dot} cm{sup {minus}2}, irradiation time of 10 min and with the assumption of 100% intensity for 260.1 and 421.5 keV {gamma}-rays, a cross-section of 12.0 {+-} 2.5 b was calculated for burn-up cross-section of {sup 188}W, which helps explain the greatly reduced production yields of {sup 188}W
Direct observation of incommensurate magnetism in Hubbard chains
The interplay between magnetism and doping is at the origin of exotic
strongly correlated electronic phases and can lead to novel forms of magnetic
ordering. One example is the emergence of incommensurate spin-density waves
with a wave vector that does not match the reciprocal lattice. In one dimension
this effect is a hallmark of Luttinger liquid theory, which also describes the
low energy physics of the Hubbard model. Here we use a quantum simulator based
on ultracold fermions in an optical lattice to directly observe such
incommensurate spin correlations in doped and spin-imbalanced Hubbard chains
using fully spin and density resolved quantum gas microscopy. Doping is found
to induce a linear change of the spin-density wave vector in excellent
agreement with Luttinger theory predictions. For non-zero polarization we
observe a decrease of the wave vector with magnetization as expected from the
Heisenberg model in a magnetic field. We trace the microscopic origin of these
incommensurate correlations to holes, doublons and excess spins which act as
delocalized domain walls for the antiferromagnetic order. Finally, when
inducing interchain coupling we observe fundamentally different spin
correlations around doublons indicating the formation of a magnetic polaron
towards time-resolved imaging of molecular structure
We demonstrate an experimental method to record snapshot diffraction images of
polyatomic gas-phase molecules, which can, in a next step, be used to probe
time-dependent changes in the molecular geometry during photochemical
reactions with femtosecond temporal and angstrom spatial resolution.
Adiabatically laser-aligned 1-ethynyl-4-fluorobenzene (C8H5F) molecules were
imaged by diffraction of photoelectrons with kinetic energies between 31 and
62 eV, created from core ionization of the fluorine (1s) level by ≈80 fs x-ray
free-electron-laser pulses. Comparison of the experimental photoelectron
angular distributions with density functional theory calculations allows
relating the diffraction images to the molecular structure
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