Tratamiento informativo de la inmigración en la valla de Melilla en eldiario.es y elmundo.es

Este trabajo de investigación analiza cuál ha sido el tratamiento informativo de la inmigración en la valla de Melilla por los diarios digitales españoles eldiario.es y elmundo.es durante el periodo comprendido entre diciembre de 2014 y enero de 2016 ya que corresponde al momento de menos atención mediática sobre la alambrada. Para ello, se ha realizado un análisis de contenido de las publicaciones de ambos diarios de dónde, a través de una serie de variables, se ha podido demostrar cuál es el tratamiento informativo de cada uno de ellos y, además, se ha realizado una comparativa entre ambos.This research work will analyze the news reporting of immigration in the border fence at Melilla by the digital newspapers eldiario.es and elmundo.es during the period from December 2014 to January 2016 as it corresponds with the moment of least media attention about the barbed-wire entanglement. For that purpose, an exhaustive analysis of the content of the publications by both newspapers has been made, from which, through several variables, it has been possible to prove which was the information treatment of both of them. Moreover, a comparison between them has also been accomplished.Departamento de Historia Moderna, Contemporánea y de América, Periodismo y Comunicación Audiovisual y PublicidadGrado en Periodism

Sistematización de práctica profesional programa de riesgo químico en la empresa instalaciones hidráulicas, sanitarias y gas HQ S.A.S

Reconstruir la experiencia de la práctica profesional orientada al programa de riesgo químico en Instalaciones Hidráulicas, Sanitarias y Gas HQ S.A.SEl presente trabajo responde a la sistematización de la práctica profesional desarrollada en INSTALACIONES HIDRÁULICAS, SANITARIAS Y GAS HQ S.A.S, relacionada con el programa de riesgo químico durante el periodo II del año 2018. Esta vivencia permitió afianzar nuevos conocimientos y poner en práctica aquellos adquiridos en las aulas. Los productos químicos representan hoy por hoy un beneficio y a su vez un “problema” para la sociedad y las empresas, sus usos se dan en varios ámbitos, lo que conlleva a que la economía, cultura, avances sociales y de productividad marchen con mayor facilidad. Sin embargo, estos productos pueden traer consecuencias y graves afecciones para la salud de los colaboradores, las personas en general y el medio ambiente, debido a que, varios de ellos contienen compuestos altamente peligrosos desencadenantes de sinergia o antagonismo en el organismo, de acuerdo a sus condiciones físicas, de almacenamiento, reactividad, dosis, tiempo de exposición y demás que pueden implicar o exacerbar riesgos latentes que con el paso del tiempo se materializan. Un gran número de sustancias químicas se han identificado a lo largo de los años como “peligrosas” o “tóxicas”, dado que, han ocasionado importantes intoxicaciones, lesiones e impactos ambientales. Es por esto que, una gran proporción de actividades económicas le han prestado atención especial y han priorizado su intervención de forma oportuna, ejerciendo controles capaces de minimizar el riesgo. A través del presente trabajo se presentarán antecedentes históricos, contextuales y legales del riesgo químico, visto desde el sistema de comunicación implementado por Naciones Unidas y determinado como Sistema Globalmente Armonizado, que actualmente se exige a las empresas en el país mediante el Artículo No 33 de la Resolución 0312 de 2019. Este sistema fue diseñado básicamente para crear unanimidad Mundial relacionada con el riesgo químico y sus efectos físicos, a la salud y al medio ambiente. Posteriormente se presentará información relacionada con el desarrollo de la práctica profesional, sus ámbitos, la ejecución de entregables y las responsabilidades de las partes involucradas, de acuerdo, a las necesidades evaluadas durante un proceso inicial de inspección. Del mismo modo se presentarán los aportes que se obtuvieron mediante la ejecución del proceso de práctica para el estudiante y la empresa en los ámbitos humano, social, técnico, económico, profesional y de comunicación y divulgación. Finalmente, se logra concluir que durante la ejecución de la sistematización el estudiante ejecutante, evalúa el desarrollo de su práctica y nuevamente le surgen ideas que hubiese podido llevar a cabo en aquel momento, lo que permite que el estudiante desarrolle su capacidad laboral y que lo que está diseñando en su cabeza lo lleve a la realidad en un futuro desempeñándose como Administrador en Salud ocupacional.This work responds to the systematization of professional practice developed in INSTALACIONES HIDRÁULICAS, SANITARIAS Y GAS HQ S.A.S (Hydraulic, Sanitary and Gas HQ facilities), related to the chemical risk program during second period of 2018. This experience allowed to consolidate new knowledge and put into practice those acquired in classrooms. Chemicals today represent a benefit and in turn a "problem" for society and companies, its uses occur in various spheres, which means that the economy, culture, social and productivity advances move more easily. However, these products can bring consequences and serious effects on the health of employees, people in general and the environment, because several of them contain highly dangerous compounds that trigger synergy or antagonism in the organism, according to its physical conditions, storage, reactivity, dose, exposure time and others that may imply or exacerbate latent risks that materialize over time. A large number of chemical substances have been identified over the years as “dangerous” or “toxic”, since they have caused significant poisonings, injuries and environmental impacts. This is why a large proportion of economic activities have paid special attention to it and have prioritized its intervention in a timely manner, exercising controls capable of minimizing risk. Through this work, historical, contextual and legal antecedents of chemical risk will be presented, seen from the communication system implemented by the United Nations and determined as a Globally Harmonized System, which is currently required of companies in the country through Article No. 33 of Resolution 0312 of 2019. This system was basically designed to create global unanimity related to chemical risk and its physical, health and environmental effects. Subsequently, information related to the development of the professional practice, its areas, the execution of deliverables and the responsibilities of the parties involved will be presented according to the needs evaluated during an initial process of inspection. In the same way, the contributions obtained through the execution of the practice process for the student and the company in the human fields, social, technical, economic, professional and communication and outreach. Finally, it is possible to conclude that during the execution of the systematization the executing student evaluates the development of his practice and once again ideas come up that he could have carried out at that time, allowing the student to develop his/her working capacity and that he/she is designing in his/her head will be taken to reality in the future by serving as an Occupational Health Administrator

Sistematización de práctica profesional programa de riesgo químico en la empresa instalaciones hidráulicas, sanitarias y gas HQ S.A.S

Reconstruir la experiencia de la práctica profesional orientada al programa de riesgo químico en Instalaciones Hidráulicas, Sanitarias y Gas HQ S.A.SEl presente trabajo responde a la sistematización de la práctica profesional desarrollada en INSTALACIONES HIDRÁULICAS, SANITARIAS Y GAS HQ S.A.S, relacionada con el programa de riesgo químico durante el periodo II del año 2018. Esta vivencia permitió afianzar nuevos conocimientos y poner en práctica aquellos adquiridos en las aulas. Los productos químicos representan hoy por hoy un beneficio y a su vez un “problema” para la sociedad y las empresas, sus usos se dan en varios ámbitos, lo que conlleva a que la economía, cultura, avances sociales y de productividad marchen con mayor facilidad. Sin embargo, estos productos pueden traer consecuencias y graves afecciones para la salud de los colaboradores, las personas en general y el medio ambiente, debido a que, varios de ellos contienen compuestos altamente peligrosos desencadenantes de sinergia o antagonismo en el organismo, de acuerdo a sus condiciones físicas, de almacenamiento, reactividad, dosis, tiempo de exposición y demás que pueden implicar o exacerbar riesgos latentes que con el paso del tiempo se materializan. Un gran número de sustancias químicas se han identificado a lo largo de los años como “peligrosas” o “tóxicas”, dado que, han ocasionado importantes intoxicaciones, lesiones e impactos ambientales. Es por esto que, una gran proporción de actividades económicas le han prestado atención especial y han priorizado su intervención de forma oportuna, ejerciendo controles capaces de minimizar el riesgo. A través del presente trabajo se presentarán antecedentes históricos, contextuales y legales del riesgo químico, visto desde el sistema de comunicación implementado por Naciones Unidas y determinado como Sistema Globalmente Armonizado, que actualmente se exige a las empresas en el país mediante el Artículo No 33 de la Resolución 0312 de 2019. Este sistema fue diseñado básicamente para crear unanimidad Mundial relacionada con el riesgo químico y sus efectos físicos, a la salud y al medio ambiente. Posteriormente se presentará información relacionada con el desarrollo de la práctica profesional, sus ámbitos, la ejecución de entregables y las responsabilidades de las partes involucradas, de acuerdo, a las necesidades evaluadas durante un proceso inicial de inspección. Del mismo modo se presentarán los aportes que se obtuvieron mediante la ejecución del proceso de práctica para el estudiante y la empresa en los ámbitos humano, social, técnico, económico, profesional y de comunicación y divulgación. Finalmente, se logra concluir que durante la ejecución de la sistematización el estudiante ejecutante, evalúa el desarrollo de su práctica y nuevamente le surgen ideas que hubiese podido llevar a cabo en aquel momento, lo que permite que el estudiante desarrolle su capacidad laboral y que lo que está diseñando en su cabeza lo lleve a la realidad en un futuro desempeñándose como Administrador en Salud ocupacional.This work responds to the systematization of professional practice developed in INSTALACIONES HIDRÁULICAS, SANITARIAS Y GAS HQ S.A.S (Hydraulic, Sanitary and Gas HQ facilities), related to the chemical risk program during second period of 2018. This experience allowed to consolidate new knowledge and put into practice those acquired in classrooms. Chemicals today represent a benefit and in turn a "problem" for society and companies, its uses occur in various spheres, which means that the economy, culture, social and productivity advances move more easily. However, these products can bring consequences and serious effects on the health of employees, people in general and the environment, because several of them contain highly dangerous compounds that trigger synergy or antagonism in the organism, according to its physical conditions, storage, reactivity, dose, exposure time and others that may imply or exacerbate latent risks that materialize over time. A large number of chemical substances have been identified over the years as “dangerous” or “toxic”, since they have caused significant poisonings, injuries and environmental impacts. This is why a large proportion of economic activities have paid special attention to it and have prioritized its intervention in a timely manner, exercising controls capable of minimizing risk. Through this work, historical, contextual and legal antecedents of chemical risk will be presented, seen from the communication system implemented by the United Nations and determined as a Globally Harmonized System, which is currently required of companies in the country through Article No. 33 of Resolution 0312 of 2019. This system was basically designed to create global unanimity related to chemical risk and its physical, health and environmental effects. Subsequently, information related to the development of the professional practice, its areas, the execution of deliverables and the responsibilities of the parties involved will be presented according to the needs evaluated during an initial process of inspection. In the same way, the contributions obtained through the execution of the practice process for the student and the company in the human fields, social, technical, economic, professional and communication and outreach. Finally, it is possible to conclude that during the execution of the systematization the executing student evaluates the development of his practice and once again ideas come up that he could have carried out at that time, allowing the student to develop his/her working capacity and that he/she is designing in his/her head will be taken to reality in the future by serving as an Occupational Health Administrator

Análise tradutória de textos acadêmicos produzidos por estudantes surdos a partir da perspectiva dos diferentes níveis linguísticos categorizados pelo QCER

Abstract: The paper presented here brings, as a central theme, translation processes from the Brazilian Sign Language - Libras - to the Portuguese language. It is based on the analysis of academic papers written by deaf graduate students. The research seeks to present and discuss different forms of recording such texts, as well as their translation. Four different translating processes were analyzed - three dissertations and one thesis. This study carried out analysis of excerpts, taken from papers written by the subjects, categorized according to the Common European Framework of Reference for Languages (CEFR), not in order to compare the subjects, but aiming to classify the papers within different linguistic levels of acquisition of a second language. Regarding theoretical references, this paper is based on studies previously conducted by Rigo (2016, 2018); Segala (2010) and Segala and Quadros (2015), among other authors dedicated to the subjects of”‹”‹deafness and translation. It was noticed that for each level of linguistic production it was necessary to organize a different translation / linguistic adaptation strategy. In other words, texts produced by Portuguese-speaking users classified as C required only linguistic adaptation; for those classified as B, a combination of linguistic adaptation and translation was necessary. Finally, the subject classified as level A needed only a translation.O trabalho ora proposto traz, como tema central, os processos de tradução da Língua Brasileira de Sinais - Libras ”“”“ para a Língua Portuguesa. Tem como objeto de análise textos acadêmicos escritos por pós-graduandos surdos. Busca-se apresentar e discutir as diferentes formas de registro desses textos, bem como a tradução do material. Foram analisados quatro processos de tradução de trabalhos de pós-graduação, sendo três Dissertações e uma Tese. Este estudo realizou análise de excertos, retirados dos textos produzidos por esses sujeitos, categorizados a partir do Quadro Comum Europeu de Referência para Línguas, não para comparar os sujeitos, mas, para classificar os textos dentro de diferentes níveis linguísticos de aquisição de uma segunda língua. No que tange ao suporte teórico, este estudo alicerça-se em estudos já propostos por Rigo (2016, 2018); Segala (2010) e Segala e Quadros (2015), entre outros nomes de referência para a área da surdez e da tradução. Percebeu-se que, para cada nível de produção linguística, foi necessário organizar uma estratégia diferente de tradução/adaptação linguística. Ou seja, os textos produzidos pelos usuários de Língua Portuguesa classificados como C requereram apenas adaptação linguística; já para os classificados como B foi utilizada uma combinação de adaptação linguística e tradução. Finalmente, o classificado como nível A teve necessidade de uma tradução

Morphological and molecular characterization of the parasite Dipylidium caninum infecting an infant in Colombia. A case report

Background: Dipylidium caninum is the causal agent of dipylidiasis affecting mainly cats and dogs worldwide. Human cases of dipylidiasis are rare, and the diagnosis is prevalently based on morphological features of the parasite. Here we report the diagnosis of dipylidiasis through morphological and molecular characterization of D. caninum infecting an 11‐month‐old boy in Cajicá, Colombia. Methods: Fresh faecal samples were obtained from the infant, and morphological identification of the parasite was performed through faecal smears. DNA was extracted from proglottids and used in PCR analyses for amplification of a 653‐bp fragment of the nuclear ribosomal RNA (rRNA) encoding the 28S rRNA gene. A phylogeny study to better characterize the obtained DNA sequence was inferred using the maximum likelihood method and the Tamura‐Nei model. Results: After morphological and molecular analyses, D. caninum was identified as the etiological agent causing the infection in the infant. Results of phylogenetical analyses showed that the obtained sequence clusters within the feline genotype clade. After the diagnosis of the parasite, effective treatment with praziquantel was administered to the infant. Conclusions: This is the third human case of dipylidiasis reported in Colombia, and the first study in South America to provide a molecular identification of D. caninum

Clinical Outcomes of Community-Acquired Pneumonia in Patients with Diabetes Mellitus

Background: Studies have found admission hyperglycemia as a predictor of poor outcomes in Community acquired Pneumonia (CAP), whereas others have not. The objective of this study was to evaluate the impact of diabetes mellitus (DM) on mortality as well as Length of stay (LOS) and Time to clinical stability (TCS) of hospitalized patients with CAP. Materials and Methods: Adult patients hospitalized with CAP enrolled at Community-Acquired Pneumonia Organization (CAPO) database with DM were categorized as admission blood glucose ≥ 250 mg/dL (diabetes mellitus blood sugar (BG) \u3e 250) and admission blood glucose ≤ 250 mg/dL (DM BG ≤ 250). CAP outcomes included: all-cause in-hospital mortality, all-cause 28-day mortality, length of stay (LOS) and time to clinical stability (TCS). Results: From a total of 7,303 patients with CAP, 294 (17.7%) had DM; out of whom 960 (13.1%) patients had BG ≤ 250 mg/dL, and 334 (4.6%) patients had BG \u3e 250 mg/dL. The in-hospital mortality was 9.3% for controls, 9.9% for the DM BG ≤ 250 mg/dL group and 13.4% for DM BG \u3e 250 mg/dL group (p = 0.04). Patients with DM BG \u3e 250 mg/dL compared to the control group had a higher risk of in-hospital mortality (Hazard ratio (RR) = 1.32, 95% CI: 1.02-1.72, p = 0.034) and 28-day mortality (RR = 1.31, 95% CI: 1.01-1.71, p = 0.048). Patients in the DM BG ≤ 250 mg/dL group compared to the control group did not have a greater risk for in-hospital mortality (RR = 1.23, 95% CI: 0.16-8.09, p = 0.237), 28-day mortality (RR = 1.09, 95% CI: 0.90-1.32, p = 0.398), LOS (HR = 0.93, 95% CI: 0.85-1.02, p = 0.130), or TCS (HR = 0.95, 95% CI: 0.87-1.05, p = 0.320). Conclusions: DM patients with BG \u3e 250 mg/dL were associated with increased in-hospital mortality and 28-day mortality. Further studies are needed to link the role of hyperglycemia to CAP outcome

Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus

Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is reported by 15% of the population and it is usually associated with hearing and/or brain disorders. The role of structural variants (SVs) in coding and non-coding regions has not been investigated in patients with severe tinnitus. In this study, we performed whole-genome sequencing in 97 unrelated Swedish individuals with chronic tinnitus (TIGER cohort). Rare single nucleotide variants (SNV), large structural variants (LSV), and copy number variations (CNV) were retrieved to perform a gene enrichment analysis in TIGER and in a subgroup of patients with severe tinnitus (SEVTIN, n = 34), according to the tinnitus handicap inventory (THI) scores. An independent exome sequencing dataset of 147 Swedish tinnitus patients was used as a replication cohort (JAGUAR cohort) and population-specific datasets from Sweden (SweGen) and Non-Finish Europeans (NFE) from gnomAD were used as control groups. SEVTIN patients showed a higher prevalence of hyperacusis, hearing loss, and anxiety when they were compared to individuals in the TIGER cohort. We found an enrichment of rare missense variants in 6 and 8 high-constraint genes in SEVTIN and TIGER cohorts, respectively. Of note, an enrichment of missense variants was found in the CACNA1E gene in both SEVTIN and TIGER. We replicated the burden of missense variants in 9 high-constrained genes in the JAGUAR cohort, including the gene NAV2, when data were compared with NFE. Moreover, LSVs in constrained regions overlapping CACNA1E, NAV2, and TMEM132D genes were observed in TIGER and SEVTIN.publishedVersio

The statistical analysis plan for the unification of treatments and interventions for tinnitus patients randomized clinical trial (UNITI-RCT)

Background Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction of tinnitus distress; however, little is known about the potentially increased effectiveness of a combination of treatments and personalized treatments for each tinnitus patient. Methods Within the Unification of Treatments and Interventions for Tinnitus Patients project, a multicenter, randomized clinical trial is conducted with the aim to compare the effectiveness of single treatments and combined treatments on tinnitus distress (UNITI-RCT). Five different tinnitus centers across Europe aim to treat chronic tinnitus patients with either cognitive behavioral therapy, sound therapy, structured counseling, or hearing aids alone, or with a combination of two of these treatments, resulting in four treatment arms with single treatment and six treatment arms with combinational treatment. This statistical analysis plan describes the statistical methods to be deployed in the UNITI-RCT. Discussion The UNITI-RCT trial will provide important evidence about whether a combination of treatments is superior to a single treatment alone in the management of chronic tinnitus patients. This pre-specified statistical analysis plan details the methodology for the analysis of the UNITI trial results. Trial registration ClinicalTrials.gov NCT04663828. The trial is ongoing. Date of registration: December 11, 2020. All patients that finished their treatment before 19 December 2022 are included in the main RCT analysis

Potencial efecto antiviral de un péptido antimicrobiano (Frenatina 2.3s) contra el virus del Dengue-2

Colombia es uno de los países de las Américas más afectado por el virus del Dengue (DENV), ya que es una enfermedad endémica y aproximadamente 23 millones de personas están en riesgo de adquirirla. Actualmente solo hay una vacuna en fase 3 de tratamiento clínico. La necesidad de encontrar nuevas moléculas con potencial terapéutico ha permitido el auge de la investigación relacionada con los péptidos antimicrobianos (AMP), como potenciales moléculas antivirales y terapéuticas. En este estudio se evaluó el péptido Frenatina 2.3S para evidenciar si tenía algún efecto de protección contra la infección del virus del Dengue-2 en células Vero. Metodología: Se cultivó DENV-2 en la línea celular Vero y se cuantificó mediante dosis infectiva de tejido celular 50. Se realizaron pruebas de citotoxicidad del virus y el péptido frente a las células y un ensayo antiviral para evidenciar la capacidad de protección al día 2, 4 y 6 pos-infección. Resultados: La Frenatina 2.3S no presentó actividad citotóxica en las células vero entre concentraciones de 0-100æM. Por otro lado, este péptido demostró una capacidad de protección hasta el 6 día pos-infección, de cerca del 80% de las células vero frente al DENV-2. Discusión: Se evidenció que al 6 día pos-infección el péptido presento una actividad de protección de cerca del 80%. Los ensayos antivirales se realizaron con una sola dilución con base en la DITC50, por lo cual se propuso ampliar el rango de concentración viral para evidenciar si el péptido conserva o cambia su nivel de protección. Se plantearon posibles mecanismos de acción del péptido en la interacción virus-célula hospedera. Conclusión: La Frenatina 2.3S presenta un porcentaje de protección alto contra el DENV-2, sin embargo, quedan abiertos muchos interrogantes a nivel de concentración y acción del péptido frente a la actividad del virus y la célula blanco.In the Americas, Colombia is one of the countries most affected by Dengue virus (DENV), as it is an endemic disease and, approximately 23 million people are at risk of acquiring it. Currently, there is only one Phase 3 vaccine for clinical treatment. The need of finding new molecules with therapeutic potential has allowed an increase in research related to antimicrobial peptides (AMP) as potential antiviral and therapeutic molecules. This study aimed to evaluate Frenatin 2.3S peptide protective effect against Dengue-2 virus infection in Vero cells. Methodology: DENV-2 was cultured in Vero cells and quantified by Tissue Culture Infectious Dose. Cytotoxicity tests of the virus and the peptide against the cells were performed, as well as an antiviral test, in order to demonstrate the protection ability at 2 , 4 and 6 days post-infection. Results: Frenatine 2.3S did not show cytotoxic activity in Vero cells in concentrations 0-100æM. On the other hand, this peptide showed a protective capacity of about 80% of Vero cells against DENV-2, until 6 days post-infection. Discussion: at 6 days post-infection the peptide showed a protective activity of about 80%. Antiviral assays were performed with a single dilution based on TCIDC50, so it was proposed to extend the range of viral concentration to evaluate if the peptide retains or changes its level of protection. Possible mechanisms of action of the peptide in the virus-host cell interaction were suggested. Conclusion: Frenatine 2.3S has a high percentage of protection against DENV-2, however, many questions remain to be answered regarding the concentration and action of the peptide against the activity of the virus and the white cell.Magíster en Ciencias BiológicasMaestrí